The emerging applications and advancements of Raman spectroscopy in pediatric cancers

Abstract

Although the survival rate of pediatric cancer has significantly improved, it is still an important cause of death among children. New technologies have been developed to improve the diagnosis, treatment, and prognosis of pediatric cancers. Raman spectroscopy (RS) is a non-destructive analytical technique that uses different frequencies of scattering light to characterize biological specimens. It can provide information on biological components, activities, and molecular structures. This review summarizes studies on the potential of RS in pediatric cancers. Currently, studies on the application of RS in pediatric cancers mainly focus on early diagnosis, prognosis prediction, and treatment improvement. The results of these studies showed high accuracy and specificity. In addition, the combination of RS and deep learning is discussed as a future application of RS in pediatric cancer. Studies applying RS in pediatric cancer illustrated good prospects. This review collected and analyzed the potential clinical applications of RS in pediatric cancers.

Shape complementarity processes for ultrashort-burst sensitive M13–PEG–WS2-powered MCF-7 cancer cell sensors

“…[4][5][6] In the case of cancer, it is beneficial to discover biomarkers of the inflammatory process in addition to the qualitative and quantitative identification of cancer-specific biomarkers. [7][8][9][10][11] According to Brenner et al, these biomarkers include acute-phase proteins, reactive oxygen and nitrogen species, immune-related effectors, cytokines or chemokines, mediators and prostaglandins, and cyclooxygenase-related factors. 12 The cancer cell type is a promising contender for next-generation biomarkers for applications in surveying treatment responses or unfavourable cases, diagnosis and toxicology.…”