Shape complementarity processes for ultrashort-burst sensitive M13–PEG–WS<sub>2</sub>-powered MCF-7 cancer cell sensors

Meivita, Maria P.; Go, Shao-Xiang; Mozar, Fitya S.; Li, Lunna; Tan, Yaw Sing; Bajalovic, Natasa; Loke, Desmond K.

doi:10.1039/d3nr03573e

Nanoscale

2023

DOI: 10.1039/d3nr03573e

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Shape complementarity processes for ultrashort-burst sensitive M13–PEG–WS₂-powered MCF-7 cancer cell sensors

Maria P. Meivita,

Shao-Xiang Go,

Fitya S. Mozar

et al.

Abstract: We control the electrical character of a 2D nanomaterial by using the integration of the phage-conjugated polymer and the nanosheet through shape-complementarity processes and design a sensor system for the rapid, sensitive detection of MCF-7 cells.

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Ultra-efficient MCF-7 cell ablation and chemotherapy-integrated electrothermal therapy with DOX–WS2–PEG–M13 nanostructures

Mozar,

Meivita,

et al. 2024

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Clinical trials have generated encouraging outcomes for the utility of thermal agents (TAs) in cancer thermal therapy (TT). Although the fast breakdown of TAs alleviates safety concerns, it restricts the thermal stability necessary for effective treatment. TAs with excellent thermal stability, on the other hand, deteriorate slowly. Rare are the approaches that address the trade-off between high thermal stability and quick deterioration of TAs. Here we control the thermal signature of WS2-type 2D materials by utilizing previously undescribed DOX–WS2–PEG–M13 nanostructures (we term them D nanostructures) through Joule heating phenomena, and develop an integrated system for TT for enhancing thermal performance, and simultaneously, maintaining rapid degradation, and chemotherapy for efficacious treatment. A relative cell viability of ~ 50% was achieved by the D-based TT (DTT) configuration, as well as a 1 nM drug concentration. The D-driven chemotherapy (DCT) model also attains a relative cell viability of 80% for 1 nM drug concentration, while a 1-week degradation time was revealed by the D nanostructure. Theoretical studies elucidate the drug molecule–nanostructure and drug-on-nanostructure–solution interaction-facilitated enhancement in drug loading and drug release performance in DCT varieties. As a result, this work not only proposes a “ideal TA” that circumvents TA restrictions, but also enables proof-of-concept application of WS2-based materials in chemotherapy-unified combination cancer therapy. Graphical Abstract

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Ultra-efficient MCF-7 cell ablation and chemotherapy-integrated electrothermal therapy with DOX–WS2–PEG–M13 nanostructures

Mozar,

Meivita,

et al. 2024

Discov Mater

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Shape complementarity processes for ultrashort-burst sensitive M13–PEG–WS₂-powered MCF-7 cancer cell sensors

Abstract: We control the electrical character of a 2D nanomaterial by using the integration of the phage-conjugated polymer and the nanosheet through shape-complementarity processes and design a sensor system for the rapid, sensitive detection of MCF-7 cells.

Cited by 1 publication

References 91 publications

Ultra-efficient MCF-7 cell ablation and chemotherapy-integrated electrothermal therapy with DOX–WS2–PEG–M13 nanostructures

Ultra-efficient MCF-7 cell ablation and chemotherapy-integrated electrothermal therapy with DOX–WS2–PEG–M13 nanostructures

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Shape complementarity processes for ultrashort-burst sensitive M13–PEG–WS2-powered MCF-7 cancer cell sensors

Abstract: We control the electrical character of a 2D nanomaterial by using the integration of the phage-conjugated polymer and the nanosheet through shape-complementarity processes and design a sensor system for the rapid, sensitive detection of MCF-7 cells.

Cited by 1 publication

References 91 publications

Ultra-efficient MCF-7 cell ablation and chemotherapy-integrated electrothermal therapy with DOX–WS2–PEG–M13 nanostructures

Ultra-efficient MCF-7 cell ablation and chemotherapy-integrated electrothermal therapy with DOX–WS2–PEG–M13 nanostructures

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Shape complementarity processes for ultrashort-burst sensitive M13–PEG–WS₂-powered MCF-7 cancer cell sensors