Role of 1α,25(OH)2 vitamin D3 on α-[1-14C]MeAIB accumulation in immature rat testis

Menegaz, Danusa; Rosso, Angela Del; Royer, Carine; Leite, L.; Santos, Adair R.S.; Silva, Fátima R M B

doi:10.1016/j.steroids.2008.11.015

Cited by 31 publications

(43 citation statements)

References 39 publications

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“…However, the specific mechanisms by which vitamin D influences male reproduction remain obscure (Cornwall, 2009). Optimal sperm function may thus depend on a direct effect of vitamin D. However, it may also be influenced indirectly through calcium homeostasis as impaired fertility in animal models was partly restored solely after normalization of serum calcium levels (Kidroni et al, 1983;Uhland et al, 1992;Menegaz et al, 2009). Based on the results obtained, 20% of young men had sperm levels below the recommended WHO levels and 40% presented with sperm concentrations below a level considered optimal for fertility.…”

Section: Discussionmentioning

confidence: 99%

Association of vitamin D status with semen quality and reproductive hormones in Iranian subfertile men

et al. 2016

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SUMMARYAlthough vitamin D deficiency is one of the most common health problems throughout the world, including Iran, conflicting information exists on the potential association between serum vitamin D levels and semen quality. This study intended to evaluate the association between serum vitamin D [25(OH) D3] with semen quality and hormones in Iranian subfertile men. We also compared mean vitamin D and hormone levels in normospermic men with oligoasthenoteratozoospermia (OAT) men. This cross-sectional study was conducted on 278 men who were referred to Royan Infertility Clinic (Tehran, Iran) from March to September 2014. The participants were categorized into two groups; of 186 normospermic and 92 OAT patients according to World Health Organization 2010 criteria. Each participant provided informed consent prior to launching research. Participants completed two general questionnaires of nutritional status. Blood and semen samples were obtained for assessment, and all data were adjusted for age, body mass index (BMI), and season. Vitamin D levels were classified according to Institute of Medicine guidelines. Vitamin D deficiency, insufficiency, and normal levels were observed in 8.6%, 43.6%, 47.8% of participants, respectively. No association was found between daily dietary intake of vitamin D and calcium with sperm parameters. Serum vitamin D was inversely correlated with PTH (p < 0.045). In normospermic men, serum vitamin D levels categorized were not correlated with semen parameters and reproductive hormones (FSH, LH, testosterone(T), and FT), whereas sperm motility showed a positive correlation with vitamin D categorized in OAT men (rs = 0.131, p = 0.028). In conclusion, there was a high incidence of deficiency and insufficiency 25(OH) D Levels (<20ng/ml) observed in Iranian men (52.2%). Moreover, our findings showed a correlation between vitamin D levels and sperm motility in OAT men, which requires further studies.

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Section: Discussionmentioning

confidence: 99%

Association of vitamin D status with semen quality and reproductive hormones in Iranian subfertile men

et al. 2016

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“…The authors' conclusion from this study was that vitamin D plays an important role in the testis by genomic effects that can be triggered by protein kinase A as well as by rapid responses involving Ca 2C /K C channels on the plasma membrane (44). In addition, Akerstrom & Walters (45) showed an increased calcium uptake in TM4 Sertoli cells shared by a nuclear receptor activity mediated through 1,25(OH) 2 D 3 , indicating that vitamin D influences testis function via dual response pathways.…”

Section: Malesmentioning

confidence: 94%

MECHANISMS IN ENDOCRINOLOGY: Vitamin D and fertility: a systematic review

Lerchbaum

Obermayer-Pietsch

2012

European Journal of Endocrinology

317

237

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Background: Vitamin D has been well-known for its function in maintaining calcium and phosphorus homeostasis and promoting bone mineralization. There is some evidence that in addition to sex steroid hormones, the classic regulators of human reproduction, vitamin D also modulates reproductive processes in women and men. Aim: The aim of this review was to assess the studies that evaluated the relationship between vitamin D and fertility in women and men as well as in animals. Methods: We performed a systematic literature search in Pubmed for relevant English language publications published until October 2011. Results and discussion: The vitamin D receptor (VDR) and vitamin D metabolizing enzymes are found in reproductive tissues of women and men. Vdr knockout mice have significant gonadal insufficiency, decreased sperm count and motility, and histological abnormalities of testis, ovary and uterus. Moreover, we present evidence that vitamin D is involved in female reproduction including IVF outcome (clinical pregnancy rates) and polycystic ovary syndrome (PCOS). In PCOS women, low 25-hydroxyvitamin D (25(OH)D) levels are associated with obesity, metabolic, and endocrine disturbances and vitamin D supplementation might improve menstrual frequency and metabolic disturbances in those women. Moreover, vitamin D might influence steroidogenesis of sex hormones (estradiol and progesterone) in healthy women and high 25(OH)D levels might be associated with endometriosis. In men, vitamin D is positively associated with semen quality and androgen status. Moreover, vitamin D treatment might increase testosterone levels. Testiculopathic men show low CYP21R expression, low 25(OH)D levels, and osteoporosis despite normal testosterone levels.

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“…Vitamin D deficiency causes gonadal insufficiency in rats [25]. At the cellular level, 1,25(OH) 2 -D 3 triggers short-term physiological events including Ca 2+ uptake activation [26], and PKA-dependent amino acid accumulation that involves Ca 2+ and K + channels present in Sertoli cell plasma membrane [27].…”

Section: Introductionmentioning

confidence: 99%

1α,25(OH)2-Vitamin D3 stimulation of secretion via chloride channel activation in Sertoli cells

Menegaz

Barrientos‐Durán

Kline

et al. 2010

The Journal of Steroid Biochemistry and Molecular Biology

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Role of 1α,25(OH)2 vitamin D3 on α-[1-14C]MeAIB accumulation in immature rat testis

Cited by 31 publications

References 39 publications

Association of vitamin D status with semen quality and reproductive hormones in Iranian subfertile men

Association of vitamin D status with semen quality and reproductive hormones in Iranian subfertile men

MECHANISMS IN ENDOCRINOLOGY: Vitamin D and fertility: a systematic review

1α,25(OH)2-Vitamin D3 stimulation of secretion via chloride channel activation in Sertoli cells

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