1α,25(OH)2-Vitamin D3 stimulation of secretion via chloride channel activation in Sertoli cells

Menegaz, Danusa; Barrientos‐Durán, Antonio; Kline, Andrew; Silva, Fátima R M B; Norman, Anthony W.; Mizwicki, Mathew T.; Zanello, Laura P.

doi:10.1016/j.jsbmb.2010.01.011

Cited by 51 publications

(67 citation statements)

References 47 publications

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“…The transform is compulsory for genomic effects, whereas the cis conformation is necessary for rapid effects (expertly reviewed by Haussler et al 2011). Unfortunately, investigations of VDR-mediated rapid responses have only been performed in vitro, showing rapid alterations in insulin secretion in β-cells (Kajikawa et al 1999), vascular smooth muscle cell migration (Rebsamen et al 2002), spermatozoa motility (Blomberg Jensen et al 2011) and calcium flux in Sertoli cells, osteoblasts, spermatozoa and intestinal cells (Norman et al 1997, Menegaz et al 2010, Blomberg Jensen et al 2011). Therefore, whether or not these alternative signalling mechanisms are physiologically relevant remain to be determined.…”

Section: Ligand and Receptor Interactionsmentioning

confidence: 99%

Molecular actions of vitamin D in reproductive cell biology

et al. 2017

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Vitamin D (VitD) is an important secosteroid and has attracted attention in several areas of research due to common VitD deficiency in the population, and its potential to regulate molecular pathways related to chronic and inflammatory diseases. VitD metabolites and the VitD receptor (VDR) influence many tissues including those of the reproductive system. VDR expression has been demonstrated in various cell types of the male reproductive tract, including spermatozoa and germ cells, and in female reproductive tissues including the ovaries, placenta and endometrium. However, the molecular role of VitD signalling and metabolism in reproductive function have not been fully established. Consequently, the aim of this work is to review current metabolic and molecular aspects of the VitD-VDR axis in reproductive medicine and to propose the direction of future research. Specifically, the influence of VitD on sperm motility, calcium handling, capacitation, acrosin reaction and lipid metabolism is examined. In addition, we will also discuss the effect of VitD on sex hormone secretion and receptor expression in primary granulosa cells, along with the impact on cytokine production in trophoblast cells. The review concludes with a discussion of the recent developments in VitD-VDR signalling specifically related to altered cellular bioenergetics, which is an emerging concept in the field of reproductive medicine.Reproduction (2017) 153 R29-R42

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Section: Ligand and Receptor Interactionsmentioning

confidence: 99%

Molecular actions of vitamin D in reproductive cell biology

et al. 2017

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“…This includes the enhanced intestinal absorption of calcium as well as increases in intracellular calcium concentrations in skeletal and cardiac myocytes, fibroblasts and osteoblasts [103][104][105][106][107]. Non-genomic effects 1,25(OH) 2 D 3 have also been demonstrated on calcium signaling in pancreatic β-cell cells [108], the rate of migration of endothelial cells [109], the opening of calcium and chloride channels in Sertoli cells [110] as well as increases in second messenger systems in parathyroid cells, osteoblasts, hepatocytes, chondrocytes and epithelial cells [106,111,112]. There appear to be instances of cross-talk between the rapid response and genomic vitamin D pathways.…”

Section: Non-genomic Actionsmentioning

confidence: 99%

The role of telomeres and vitamin D in cellular aging and age-related diseases

Pusceddu

Farrell²,

Pierro

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

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Aging is a complex biological process characterized by a progressive decline of organ functions leading to an increased risk of age-associated diseases and death. Decades of intensive research have identified a range of molecular and biochemical pathways contributing to aging. However, many aspects regarding the regulation and interplay of these pathways are insufficiently understood. Telomere dysfunction and genomic instability appear to be of critical importance for aging at a cellular level. For example, age-related diseases and premature aging syndromes are frequently associated with telomere shortening. Telomeres are repetitive nucleotide sequences that together with the associated sheltrin complex protect the ends of chromosomes and maintain genomic stability. Recent studies suggest that micronutrients, such as vitamin D, folate and vitamin B12, are involved in telomere biology and cellular aging. In particular, vitamin D is important for a range of vital cellular processes including cellular differentiation, proliferation and apoptosis. As a result of the multiple functions of vitamin D it has been speculated that vitamin D might play a role in telomere biology and genomic stability. Here we review existing knowledge about the link between telomere biology and cellular aging with a focus on the role of vitamin D. We searched the literature up to November 2014 for human studies, animal models and in vitro experiments that addressed this topic.

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“…2). VDR is expressed in both nucleus and cytoplasm of primary cultures of immature Sertoli cells and in the immature mice Sertoli cell line TM4, and 1,25(OH) 2 D 3 mediates fast nongenomic effects in both cell lines (Akerstrom & Walters 1992, Majumdar et al 1994, Menegaz et al 2010, 2011, Rosso et al 2011, Zanatta et al 2011a, 2011b. VDR is also expressed in spermatocytes and spermatids of both rodents and humans (Blomberg Jensen et al 2010a, 2010b, Zanatta et al 2011c, but Sertoli cells are still considered to be the main VD target in the adult testis (Zanatta et al 2011c).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D metabolism, sex hormones, and male reproductive function

Jensen¹

2012

Reproduction

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The spectrum of vitamin D (VD)-mediated effects has expanded in recent years, and VD is now recognized as a versatile signaling molecule rather than being solely a regulator of bone health and calcium homeostasis. One of the recently identified target areas of VD is male reproductive function. The VD receptor (VDR) and the VD metabolizing enzyme expression studies documented the presence of this system in the testes, mature spermatozoa, and ejaculatory tract, suggesting that both systemic and local VD metabolism may influence male reproductive function. However, it is still debated which cell is the main VD target in the testis and to what extent VD is important for sex hormone production and function of spermatozoa. This review summarizes descriptive studies on testicular VD metabolism and spatial distribution of VDR and the VD metabolizing enzymes in the mammalian testes and discusses mechanistic and association studies conducted in animals and humans. The reviewed evidence suggests some effects of VD on estrogen and testosterone biosynthesis and implicates involvement of both systemic and local VD metabolism in the regulation of male fertility potential.

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1α,25(OH)2-Vitamin D3 stimulation of secretion via chloride channel activation in Sertoli cells

Cited by 51 publications

References 47 publications

Molecular actions of vitamin D in reproductive cell biology

Molecular actions of vitamin D in reproductive cell biology

The role of telomeres and vitamin D in cellular aging and age-related diseases

Vitamin D metabolism, sex hormones, and male reproductive function

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