Molecular actions of vitamin D in reproductive cell biology

Keane, Kevin N.; Cruzat, Vinícius Fernandes; Calton, Emily K.; Hart, Prue H.; Soares, Mário J.; Newsholme, Philip; Yovich, John L.

doi:10.1530/rep-16-0386

Cited by 35 publications

(22 citation statements)

References 103 publications

(93 reference statements)

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“…In contrast to previous reports, 8,27,44 we show here that VDD alone (without hypocalcemia) did not reduce sperm cell motility, regardless of the severity of VDD. We therefore reinforce the idea that the previously reported reduction in sperm motility in VDD cases was likely a calcium‐mediated effect, as suggested 8,27‐49 . The results of our experiments are therefore in complete agreement with Sun et al 27 who demonstrated that VDD is accompanied by decreased extracellular calcium and phosphorus levels and that defective sperm motility in these situations can be overcome by calcium and phosphorus supplements.…”

Section: Discussionsupporting

confidence: 93%

Impact of vitamin D deficiency on mouse sperm structure and function

et al. 2020

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Background In rodents and humans, vitamin D deficiency (VDD) is associated with altered sperm structure and function (primarily decreased motility and morphological abnormalities) that are primarily attributed to VDD‐induced hypocalcemia. However, it is suspected that VDD has much more drastic effects on mammalian spermatozoa. Objectives The purpose of this study was to illustrate that VDD, depending on its severity and duration, can alter sperm nuclear integrity and can also lead to the loss of spermatozoa's ability to support embryonic development. Materials and methods A mouse model of induced VDD combining the action of a vitamin D‐deficient diet, UV exposure limitation, and paricalcitol injections; a vitamin D2 analog that catabolizes endogenous vitamin D by increasing the expression of CYP24A, a member of the cytochrome P450 family, has been used to create different grades of VDD. Results We show that the most significant sperm defect recorded concerns the integrity of the paternal nucleus, which is both decondensed and fragmented in moderate‐to‐severe VDD situations. Consistent with the known consequences of fertilization with DNA‐damaged spermatozoa, we show that paternal VDD decreases the ability of spermatozoa to optimally support fertilization and embryonic development. Discussion and Conclusion Given the worldwide high prevalence of VDD in humans, and although obtained in an animal model, the data presented here suggest that subfertile/infertile males may benefit from VDD testing and that attempts to correct serum vitamin D levels could be considered prior to conception, either naturally or through ART.

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Section: Discussionsupporting

confidence: 93%

Impact of vitamin D deficiency on mouse sperm structure and function

et al. 2020

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“…However, the conclusions of previous studies have not been completely consistent. For example, it remains unclear whether there is a relationship between VD de ciency status and PCOS in infertile women (11).Comparison of the VD levels between patients with PCOS and in the control group showed no signi cant difference (11 vs. 17 ng/ml, respectively). In recent years, many related studies have shown that the VD content in patients with PCOS may be closely related to metabolic syndrome.…”

Section: Relationship Between the Season Or Age And The Vitamin D Levelmentioning

confidence: 97%

Analysis of the relationship of the serum vitamin D level with infertility and associated factors

Zhang

et al. 2022

Preprint

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Objective: The aims of this study were to study the distribution of the serum VD levels among infertile people and to analyze the relationships between VD levels and the basic conditions of infertile patients, as well as laboratory indicators.Methods: We retrospectively reviewed the data of 12,261 infertile patients who were treated with ART for the first time in the Reproductive Medicine Center of the Third Affiliated Hospital of Zhengzhou University from June 2016 to December 2018. According to the serum 25(OH)D level, the patients were divided into the following two groups: the VD deficiency group (25(OH)D≤50 nmol/l) and VD nondeficiency group (25(OH)D>50 nmol/l). Results: Regression analysis showed that VD levels were not affected by BMI, PCOS, the blood type, family history or endometriosis (P>0.05). Advanced female age (>35 years) was a protective factor against VD deficiency; women under 35 years of age were more likely to develop VD deficiency than those over 35 years of age (P<0.05). The season of VD determination affected its level; the levels of VD in summer and autumn were significantly higher than those in winter and spring (P<0.05).They were obviously higher in spring than in winter (P<0.05). Insulin resistance affected VD levels; patients with insulin resistance were more prone to VD deficiency than those without insulin resistance (P<0.05). Conclusions: VD deficiency exists among infertile patients. The level of VD is affected by the woman's age, the season of determination and insulin resistance. BMI, PCOS, blood type, family history and endometriosis have no influence on vitamin D levels.

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“…The synthesis and activity CYP27B1 is usually regulated by the fibroblast growth factor 23 (FGF-23) [14]. Once activated, the vitamin D binds to different VDRs on different cells where it can activate transcription of different genes, thus exerting a hormone-like effect [2,15,16]. Other than skin, vitamin D can also be acquired through diet.…”

Section: Synthesis Of Vitamin Dmentioning

confidence: 99%

“…Foods rich in vitamins D 3 and D 2 are processed in the digestive tract; then, the liberated vitamin D is transported to the liver via human serum vitamin D-binding protein (DBP). After this point, the process of conversion follows the previous pathway to the liver [15]. Vitamin D is regulated by the enzyme CYP24A1 that catabolizes excess 25(OH)D3, a metabolite of vitamin D, to calcitroic acid, which is excreted through bile [17].…”

Section: Synthesis Of Vitamin Dmentioning

confidence: 99%

Immune Modulatory Effects of Vitamin D on Viral Infections

et al. 2020

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Viral infections have been a cause of mortality for several centuries and continue to endanger the lives of many, specifically of the younger population. Vitamin D has long been recognized as a crucial element to the skeletal system in the human body. Recent evidence has indicated that vitamin D also plays an essential role in the immune response against viral infections and suggested that vitamin D deficiency increases susceptibility to viral infections as well as the risk of recurrent infections. For instance, low serum vitamin D levels were linked to increased occurrence of high burdens viral diseases such as hepatitis, influenza, Covid-19, and AIDS. As immune cells in infected patients are responsive to the ameliorative effects of vitamin D, the beneficial effects of supplementing vitamin D-deficient individuals with an infectious disease may extend beyond the impact on bone and calcium homeostasis. Even though numerous studies have highlighted the effect of vitamin D on the immune cells, vitamin D’s antiviral mechanism has not been fully established. This paper reviews the recent mechanisms by which vitamin D regulates the immune system, both innate and adaptive systems, and reflects on the link between serum vitamin D levels and viral infections.

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Molecular actions of vitamin D in reproductive cell biology

Cited by 35 publications

References 103 publications

Impact of vitamin D deficiency on mouse sperm structure and function

Impact of vitamin D deficiency on mouse sperm structure and function

Analysis of the relationship of the serum vitamin D level with infertility and associated factors

Immune Modulatory Effects of Vitamin D on Viral Infections

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