MECHANISMS IN ENDOCRINOLOGY: Vitamin D and fertility: a systematic review

Lerchbaum, Elisabeth; Obermayer-Pietsch, B.

doi:10.1530/eje-11-0984

Cited by 325 publications

(285 citation statements)

References 131 publications

(155 reference statements)

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“…The VitD receptor, VDR, was first reported in 1969 as a chromatinassociated protein (Haussler & Norman 1969). The presence of proteins and enzymes involved in VitD-VDR axis has been demonstrated in various cell types of the male reproductive tract, including spermatozoa, Sertoli, Leydig and germ cells (Blomberg Jensen et al 2010, Blomberg Jensen 2014, as well as in female reproductive tissues including the ovaries, endometrium and placenta (Lerchbaum & Obermayer-Pietsch 2012, Ma et al 2012. The VDR is a transcription factor, and the VitD-VDR signalling cascade results in either activation or suppression of gene transcription.…”

Section: Canonical Vitamin D Signalling and Regulationmentioning

confidence: 99%

“…The presence of proteins and enzymes involved in VitD-VDR axis has been demonstrated in various cell types of the male and female reproductive tract (Blomberg Jensen et al 2010, Lerchbaum & Obermayer-Pietsch 2012, Ma et al 2012, Blomberg Jensen 2014. These findings suggest that VitD metabolism may play a role in male and female reproductive function.…”

Section: Molecular Vitamin D Studies In Reproductive Cellsmentioning

confidence: 99%

“…3). An additional experiment by this group showed that 1α,25(OH) 2 D increased lipase activity, while triglyceride content decreased, and they proposed that lipolysis provided the energy required to drive capacitation (Aquila et al 2009, Lerchbaum & Obermayer-Pietsch 2012.…”

Section: Molecular Mechanistic Studies In Spermmentioning

confidence: 99%

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Molecular actions of vitamin D in reproductive cell biology

et al. 2017

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Vitamin D (VitD) is an important secosteroid and has attracted attention in several areas of research due to common VitD deficiency in the population, and its potential to regulate molecular pathways related to chronic and inflammatory diseases. VitD metabolites and the VitD receptor (VDR) influence many tissues including those of the reproductive system. VDR expression has been demonstrated in various cell types of the male reproductive tract, including spermatozoa and germ cells, and in female reproductive tissues including the ovaries, placenta and endometrium. However, the molecular role of VitD signalling and metabolism in reproductive function have not been fully established. Consequently, the aim of this work is to review current metabolic and molecular aspects of the VitD-VDR axis in reproductive medicine and to propose the direction of future research. Specifically, the influence of VitD on sperm motility, calcium handling, capacitation, acrosin reaction and lipid metabolism is examined. In addition, we will also discuss the effect of VitD on sex hormone secretion and receptor expression in primary granulosa cells, along with the impact on cytokine production in trophoblast cells. The review concludes with a discussion of the recent developments in VitD-VDR signalling specifically related to altered cellular bioenergetics, which is an emerging concept in the field of reproductive medicine.Reproduction (2017) 153 R29-R42

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Section: Canonical Vitamin D Signalling and Regulationmentioning

confidence: 99%

Section: Molecular Vitamin D Studies In Reproductive Cellsmentioning

confidence: 99%

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Molecular actions of vitamin D in reproductive cell biology

et al. 2017

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“…Vitamin D is a fat-soluble secosteroid hormone endowed with pleiotropic effects [1,2]. Besides the well-known function of vitamin D in promoting in vitro bone mineralization and prevention of osteoporosis and bone fracture through intestinal calcium absorption [3,4], mounting evidence has linked hypovitaminosis D to musculoskeletal diseases [5], cancer [6], autoimmune diseases, type 2 diabetes, cardiovascular disease [6,7] and all-cause mortality [5].…”

Section: Introductionmentioning

confidence: 99%

“…Besides the well-known function of vitamin D in promoting in vitro bone mineralization and prevention of osteoporosis and bone fracture through intestinal calcium absorption [3,4], mounting evidence has linked hypovitaminosis D to musculoskeletal diseases [5], cancer [6], autoimmune diseases, type 2 diabetes, cardiovascular disease [6,7] and all-cause mortality [5]. The main source of vitamin D is cholecalciferol (vitamin D3), synthesized in the skin by ultraviolet radiation [2]; pro-vitamin D3 (7-dehydrocholesterol) is converted to pre-vitamin D3, which isomerizes into cholecalciferol and is later converted to calcitriol (1,25(OH) 2 D 3 ) through a two-step enzymatic pathway involving liver 25-hydroxylase (CYP2R1) andkidney 1-α-hydroxylase (CYP27B1) [2,8,9]. Vitamin D status is assessed by measuring 25(OH)D 3 [8].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D and biomarkers of sex steroid hormones are non-linearly and inversely related to all-cause mortality: results from NHANES III

Beydoun¹,

Eid²,

Jeng³

et al. 2015

Horm Stud

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Background: In men, hypovitaminosis D as well as high and low testosterone levels have been linked to adverse events, including death. A biological interaction has been previously suggested between vitamin D and androgens. In a cohort study using Third National Health and Nutrition Examination Survey data, we simultaneously investigated circulating vitamin D and biomarkers of sex steroid hormones as predictors of all-cause mortality. Methods: Age-adjusted and fully-adjusted Cox regression models were constructed to estimate hazard ratios (HR) and their 95% confidence intervals (CI). Whereas the vitamin D sufficient group (25(OH)D 3 ≥30 ng/ml) was selected as a referent, biomarkers of sex steroid hormones (testosterone, estradiol, SHBG) were defined as Loge-transformed continuous variables. Results: Of 1,472 men with a mean age of 42.1 years at baseline, 382 died over a median of 192 months of follow-up. Estradiol levels were significantly higher among vitamin D deficient compared to vitamin D sufficient men and sex hormone binding globulin level was significantly higher in vitamin D sufficient compared to vitamin D insufficient or deficient groups. An inverse non-linear relationship was observed between all-cause mortality rate and levels of testosterone, estradiol and vitamin D, in fully-adjusted models. There were no significant interaction effects between vitamin D and sex steroid hormones in relation to all-cause mortality rate. Conclusions: Vitamin D and sex steroid hormones, but not sex hormone binding globulin, may be inversely and non-linearly related to all-cause mortality among adult men, after adjustment for baseline demographic, socioeconomic, lifestyle and clinical characteristics.

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Milk Fat Globule in Ruminant: Major and Minor Compounds, Nutritional Regulation and Differences Among Species

Bernard

Bonnet

Delavaud

et al. 2018

Euro J Lipid Sci & Tech

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Recent knowledge is presented on the composition of ruminant milk fat fractions and the nutritional strategies known to alter their amount. The development of lipidomic and proteomic analyses has allowed for the characterization of minor components, such as proteins, liposoluble vitamins, and phospholipids of the milk fat globule (MFG), in addition to the triacylglycerols (TAG), which are the major constituents of the MFG core. Few differences in these components among ruminant species exist, and they have been outlined mainly on the fatty acids (FA) profile of the TAG, whereas comparative data are still lacking on vitamins and proteins. The effects of dietary treatments enriched in n‐3 polyunsaturated FA (PUFA) on the composition of the milk fat fraction are explored. In particular, pasture and plant oilseeds increase milk n‐3 PUFA and cis‐9,trans‐11 CLA and decrease saturated FA, whereas data with new feed resources, such as algae, are still rare. The peculiarities of the response of the milk fat to diets that induce a milk fat depression in cows but in lesser extent in small ruminants are described. The potential effects of polar lipids, proteins, and liposoluble vitamins of the MFG on human health are reviewed, highlighting the nutraceutical properties of milk. Practical Applications: This review provides an overview of the different components of the milk fat fraction in ruminant species and on nutritional strategies to alter their amounts to improve the nutritional quality of milk. Furthermore, this review presents recent data on species peculiarities of the milk fat fraction composition and of its response to nutritional factors, which offers a promising model to identify news levers of regulation of this fraction and foster the identification of new feeding strategies to better control milk fat composition and feed efficiency. This review synthesizes data on the composition of the milk fat fraction in ruminant species, reports advances in nutritional strategies to alter their amounts and species‐specific responses to nutrition, as well as the potential effects on human health of the major and minor components of this fraction.

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MECHANISMS IN ENDOCRINOLOGY: Vitamin D and fertility: a systematic review

Cited by 325 publications

References 131 publications

Molecular actions of vitamin D in reproductive cell biology

Molecular actions of vitamin D in reproductive cell biology

Vitamin D and biomarkers of sex steroid hormones are non-linearly and inversely related to all-cause mortality: results from NHANES III

Milk Fat Globule in Ruminant: Major and Minor Compounds, Nutritional Regulation and Differences Among Species

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