Role of 1-methyl-3-octylimidazolium chloride in the micellization behavior of amphiphilic drug amitriptyline hydrochloride

Khan, Abbul Bashar; Ali, Maroof; Malik, Nisar Ahmad; Ali, Anwar; Patel, Rajan

doi:10.1016/j.colsurfb.2013.08.018

Cited by 47 publications

(14 citation statements)

References 70 publications

(59 reference statements)

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“…In some cases for ionic systems, the continuous increase in CMC with temperature was observed [52][53][54]. However, in the case of pure AMT, the CMC values first increase with temperature and then decrease at the higher temperature [37,49]. Hence below T max (temperature at which the CMC value is maximized), the thermal solubility prevailed over dehydration and the CMC of pure AMT increases while above T max , due to high temperature micelles dehydration increases and this factor offset the solubility factor.…”

Section: Resultsmentioning

confidence: 99%

“…From the literature, the mixed micellar systems of drugcationic/gemini surfactant [36][37][38][39][40][41][42][43][44] and surfactant-IL [45][46][47] have been widely studied, but the mixture of drug-IL [48,49] have been less frequently examined. To our knowledge, no one has studied the thermodynamics of mixed micellization of drug-[C 10 -4-C 10 im]Br 2 binary mixtures.…”

Section: Introductionmentioning

confidence: 99%

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Mixed Micellization and Interfacial Properties of Ionic Liquid‐Type Imidazolium Gemini Surfactant with Amphiphilic Drug Amitriptyline Hydrochloride and its Thermodynamics

Patel

Khan

Dohare

et al. 2015

J Surfact & Detergents

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The thermodynamics of mixed micellization of amitriptyline hydrochloride (AMT) with ionic liquid-type imidazolium gemini surfactant ([C 10 -4-C 10 im] Br 2 ), was investigated at different mole fractions and temperatures by surface tension measurements. The deviation of the critical micelle concentration (CMC) from the ideal critical micelle concentration (CMC*), micellar mole fraction (X m 1 ) from ideal micellar mole fraction (X ideal 1 ), the values of interaction parameter (b) and activity coefficients (f i ) (for both mixed micelles and mixed monolayer) explained the non-ideal behavior (i.e., synergistic behavior) of binary mixtures. The excess free energy (DG ex ) for the AMT-[C 10 -4-C 10 im] Br 2 binary mixtures explained the mixed micelles stability in comparison to micelles of [C 10 -4-C 10 im] Br 2 and pure AMT. Interfacial parameters, i.e., Gibbs surface excess (C max ), minimum head group area at air/water interface (A min ), free energy of micellization (DG o m ), and standard Gibbs energy of adsorption (DG ads o ) were also evaluated for the systems. The standard entropy of adsorption (DS ads o ) was found higher than the standard entropy of micellization (DS m o ) at all mole fractions of AMT (a 1 ).

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mixed Micellization and Interfacial Properties of Ionic Liquid‐Type Imidazolium Gemini Surfactant with Amphiphilic Drug Amitriptyline Hydrochloride and its Thermodynamics

Patel

Khan

Dohare

et al. 2015

J Surfact & Detergents

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“…The first factor is to disrupt the water structure surrounding the hydrophobic group and this is not in favor of micellization. Second, to reduce the degree of hydration of hydrophilic groups and this is in favor of micellization (Ali et al, ; Din et al, ; Khan et al, ). In our study, the results indicate that the first factor is predominant for micellization in the investigated systems.…”

Section: Resultsmentioning

confidence: 99%

Investigation of Mixing Behavior of both a Conventional Surfactant and Different Inorganic Salts with a Cationic Gemini Surfactant in Aqueous Solution

Sarıkaya

Bilgen

Akbaş

2019

J Surfact & Detergents

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N,N′‐bis [3‐(dodecanoylamino)propyl]‐N,N,N′,N′‐tetramethylhexane‐1,6‐diaminium dibromide is a cationic Gemini surfactant including quaternary ammonium salt with amide groups. Critical micelle concentration (CMC) and some thermodynamic parameters of the cationic Gemini surfactant were investigated using surface tension and conductivity methods. Mixed micellization of binary mixtures of the cationic Gemini surfactant with a conventional surfactant cetyl trimethylammonium bromide (CTAB) was investigated using the conductometric method at five different temperatures ranging from 303.15 to 323.15 K. CMC, micellar ionization degree (αm), counterion binding constant (g1), interaction parameter (β), and activity coefficients (f1M and f2M) of mixed systems were found out from data of conductivity at different mole fractions for all studied temperatures. Additionally, the effects of some inorganic salts with different concentrations on the surface properties of cationic Gemini surfactant were examined by surface tension measurements. Some surface properties of the pure cationic Gemini surfactant and mixed salts systems were calculated using the data of surface tension.

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“…This is the first step for identifying ILs as potential carrier agents in drug delivery devices. Accordingly, a large number of reports comprising ILs as solvents to be employed in the development of promising drug delivery strategies have been published in the literature, namely by IL-based micelles [ 79 , 80 , 81 , 82 ], microemulsions [ 12 , 48 , 83 , 84 , 85 ], nanoparticles [ 86 , 87 , 88 , 89 , 90 ], functionalized silica [ 91 , 92 , 93 , 94 ], and iongels [ 95 , 96 , 97 , 98 ]. These possibilities stand out as the most relevant examples for delivery approaches with ILs, as summarized in Figure 4 .…”

Section: Il-based Drug Delivery Systemsmentioning

confidence: 99%

Advances Brought by Hydrophilic Ionic Liquids in Fields Involving Pharmaceuticals

et al. 2021

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The negligible volatility and high tunable nature of ionic liquids (ILs) have been the main drivers of their investigation in a wide diversity of fields, among which is their application in areas involving pharmaceuticals. Although most literature dealing with ILs is still majorly devoted to hydrophobic ILs, evidence on the potential of hydrophilic ILs have been increasingly provided in the past decade, viz., ILs with improved therapeutic efficiency and bioavailability, ILs with the ability to increase drugs' aqueous solubility, ILs with enhanced extraction performance for pharmaceuticals when employed in biphasic systems and other techniques, and ILs displaying low eco/cyto/toxicity and beneficial biological activities. Given their relevance, it is here overviewed the applications of hydrophilic ILs in fields involving pharmaceuticals, particularly focusing on achievements and advances witnessed during the last decade. The application of hydrophilic ILs within fields involving pharmaceuticals is here critically discussed according to four categories: (i) to improve pharmaceuticals solubility, envisioning improved bioavailability; (ii) as IL-based drug delivery systems; (iii) as pretreatment techniques to improve analytical methods performance dealing with pharmaceuticals, and (iv) in the recovery and purification of pharmaceuticals using IL-based systems. Key factors in the selection of appropriate ILs are identified. Insights and perspectives to bring renewed and effective solutions involving ILs able to compete with current commercial technologies are finally provided.

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Role of 1-methyl-3-octylimidazolium chloride in the micellization behavior of amphiphilic drug amitriptyline hydrochloride

Cited by 47 publications

References 70 publications

Mixed Micellization and Interfacial Properties of Ionic Liquid‐Type Imidazolium Gemini Surfactant with Amphiphilic Drug Amitriptyline Hydrochloride and its Thermodynamics

Mixed Micellization and Interfacial Properties of Ionic Liquid‐Type Imidazolium Gemini Surfactant with Amphiphilic Drug Amitriptyline Hydrochloride and its Thermodynamics

Investigation of Mixing Behavior of both a Conventional Surfactant and Different Inorganic Salts with a Cationic Gemini Surfactant in Aqueous Solution

Advances Brought by Hydrophilic Ionic Liquids in Fields Involving Pharmaceuticals

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