Roentgen Therapy with Very Small Doses: Experience in Lymphadenitis, Leukemia, Hodgkin's Disease and Certain Infections

Chamberlain, W. Edward

doi:10.3109/00016922609139490

Cited by 5 publications

(4 citation statements)

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“…An example is the study published by Oppenheimer in 1943. Satisfactory clinical outcomes were obtained after treating 56 patients with a 0.5-Gy equivalent, doses that were previously reported to satisfactorily treat bacterial lung conditions by Chamberlain [26]. Differences between three subgroups were reported, as patients who were treated from 2-5 days and 6-14 days had full symptom resolution.…”

Section: Literature Review and Discussionmentioning

confidence: 69%

Low-dose radiotherapy for COVID-19 pneumonia treatment: case report, procedure, and literature review

Del-Castillo-Pacora¹,

Martinez²,

Sarria³

et al. 2020

Strahlenther Onkol

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Background The COVID-19 pandemic outbreak has set the emergency services in developing countries on major alert, as the installed response capacities are easily overwhelmed by the constantly increasing high demand. The deficit of intensive care unit beds and ventilators in countries like Peru is forcing practitioners to seek preventive or early interventional strategies to prevent saturating these chronically neglected facilities. Case presentation A 64-year-old patient is reported after presenting with COVID-19 pneumonia and rapidly progressing to deteriorated ventilatory function. Compassionate treatment with a single 1-Gy dose to the bilateral whole-lung volume was administered, with gradual daily improvement of ventilatory function and decrease in serum inflammatory markers and oxygen support needs, including intubation. No treatment-related toxicity developed. Procedures of transport, disinfection, and treatment planning and delivery are described. Conclusion Whole-lung low-dose radiotherapy seems to be a promising approach for avoiding or delaying invasive respiratory support. Delivered low doses are far from meeting toxicity ranges. Ongoing prospective trials will elucidate the effectiveness of this approach.

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Section: Literature Review and Discussionmentioning

confidence: 69%

Low-dose radiotherapy for COVID-19 pneumonia treatment: case report, procedure, and literature review

Del-Castillo-Pacora¹,

Martinez²,

Sarria³

et al. 2020

Strahlenther Onkol

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“…In one such study, 22 out of 29 patients (75.9%) who showed no response to sulfonamides, recovered completely with x-ray therapy (120 Kv, distance 40 cm, 3 mm Al filter, 200 röntgen single-dose for a maximum of 3 doses) [15]. Some short-term adverse effects were shown by several authors, namely convulsions and cyanosis when the single session radiation dose exceeded 10 Gy [16,17]. These complications often resolved, and therapy was still effective in these patients.…”

Section: Pneumonia Treated With X-raymentioning

confidence: 99%

“…While antibodies can directly affect tumor cells, they can also be used as transport vehicles to deliver agents that can destroy tumor cells (e.g. radioisotopes) [17]. When antibodies are labeled with radioisotopes, a high dose of ionizing radiation can be delivered directly to the targeted cells.…”

Section: Radioimmunotherapymentioning

confidence: 99%

Treating infections with ionizing radiation: a historical perspective and emerging techniques

Dijk

Lemans

Hoogendoorn

et al. 2020

Antimicrob Resist Infect Control

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Background: Widespread use and misuse of antibiotics have led to a dramatic increase in the emergence of antibiotic resistant bacteria, while the discovery and development of new antibiotics is declining. This has made certain implant-associated infections such as periprosthetic joint infections, where a biofilm is formed, very difficult to treat. Alternative treatment modalities are needed to treat these types of infections in the future. One candidate that has been used extensively in the past, is the use of ionizing radiation. This review aims to provide a historical overview and future perspective of radiation therapy in infectious diseases with a focus on orthopedic infections. Methods: A systematic search strategy was designed to select studies that used radiation as treatment for bacterial or fungal infections. A total of 216 potentially relevant full-text publications were independently reviewed, of which 182 focused on external radiation and 34 on internal radiation. Due to the large number of studies, several topics were chosen. The main advantages, disadvantages, limitations, and implications of radiation treatment for infections were discussed. Results: In the pre-antibiotic era, high mortality rates were seen in different infections such as pneumonia, gas gangrene and otitis media. In some cases, external radiation therapy decreased the mortality significantly but longterm follow-up of the patients was often not performed so long term radiation effects, as well as potential increased risk of malignancies could not be investigated. Internal radiation using alpha and beta emitting radionuclides show great promise in treating fungal and bacterial infections when combined with selective targeting through antibodies, thus minimizing possible collateral damage to healthy tissue. Conclusion: The novel prospects of radiation treatment strategies against planktonic and biofilm-related microbial infections seem feasible and are worth investigating further. However, potential risks involving radiation treatment must be considered in each individual patient.

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“…Dans une série historique de 32 enfants atteints de pneumopathie interstitielle, Oppenheimer avait décrit une amélioration en moins de 24 heures des symptômes respiratoires après irradiation à des doses de l'ordre de 0,3 à 0,8 Gy (l'irradiation était pratiquée avec des rayons X de faible énergie [20]). Dans une autre série plus ancienne concernant 104 patients atteints de pneumopathie bactérienne, une amélioration très rapide, en quelques heures était observée chez la majorité des patients, les auteurs rattachaient alors la réponse clinique rapide à un effet sur les globules blancs [21], avec des doses qui étaient à l'époque communément utilisées pour traiter des infections bactériennes cutanées comme les furonculoses [22]. Ces données anciennes montrent que l'irradiation pourrait être utile dans des situations particulières, en l'absence d'efficacité des traitements spécifiques antiviraux et immunomodulateurs (anti-interleukine [IL]-6, stéroïdes à fortes doses, etc.).…”

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Irradiation pulmonaire à faible dose pour l’orage de cytokines du COVID-19 : pourquoi pas ?

Cosset

Deutsch

Bazire

et al. 2020

Cancer/Radiothérapie

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Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Roentgen Therapy with Very Small Doses: Experience in Lymphadenitis, Leukemia, Hodgkin's Disease and Certain Infections

Cited by 5 publications

References 0 publications

Low-dose radiotherapy for COVID-19 pneumonia treatment: case report, procedure, and literature review

Low-dose radiotherapy for COVID-19 pneumonia treatment: case report, procedure, and literature review

Treating infections with ionizing radiation: a historical perspective and emerging techniques

Irradiation pulmonaire à faible dose pour l’orage de cytokines du COVID-19 : pourquoi pas ?

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