Irradiation pulmonaire à faible dose pour l’orage de cytokines du COVID-19 : pourquoi pas ?

Cosset, Jean‐Marc; Deutsch, Éric; Bazire, Louis; Mazeron, Jean‐Jacques; Chargari, Cyrus

doi:10.1016/j.canrad.2020.04.003

Cited by 12 publications

(6 citation statements)

References 18 publications

(19 reference statements)

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“…Interestingly, a few researchers have proposed the use of low-dose radiation therapy to control hyper-inflammatory states in severe COVID-19 74 , 75 . According to the cited studies, low-dose radiation (usually < 1.0 Gy) has immune-modulating effects on immune cells, changing them into an anti-inflammatory phenotype.…”

Section: Treatment Of Cytokine Stormmentioning

confidence: 99%

Immunopathogenesis and treatment of cytokine storm in COVID-19

Kim¹,

Lee²,

Yang³

et al. 2021

Theranostics

366

309

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Severe coronavirus disease 2019 (COVID-19) is characterized by systemic hyper-inflammation, acute respiratory distress syndrome, and multiple organ failure. Cytokine storm refers to a set of clinical conditions caused by excessive immune reactions and has been recognized as a leading cause of severe COVID-19. While comparisons have been made between COVID-19 cytokine storm and other kinds of cytokine storm such as hemophagocytic lymphohistiocytosis and cytokine release syndrome, the pathogenesis of cytokine storm has not been clearly elucidated yet. Recent studies have shown that impaired response of type-1 IFNs in early stage of COVID-19 infection played a major role in the development of cytokine storm, and various cytokines such as IL-6 and IL-1 were involved in severe COVID-19. Furthermore, many clinical evidences have indicated the importance of anti-inflammatory therapy in severe COVID-19. Several approaches are currently being used to treat the observed cytokine storm associated with COVID-19, and expectations are especially high for new cytokine-targeted therapies, such as tocilizumab, anakinra, and baricitinib. Although a number of studies have been conducted on anti-inflammatory treatments for severe COVID-19, no specific recommendations have been made on which drugs should be used for which patients and when. In this review, we provide an overview of cytokine storm in COVID-19 and treatments currently being used to address it. In addition, we discuss the potential therapeutic role of extracorporeal cytokine removal to treat the cytokine storm associated with COVID-19.

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Section: Treatment Of Cytokine Stormmentioning

confidence: 99%

Immunopathogenesis and treatment of cytokine storm in COVID-19

Kim¹,

Lee²,

Yang³

et al. 2021

Theranostics

366

309

View full text Add to dashboard Cite

show abstract

“…Extraordinary precautionary measures have been taken to control its high incidence of morbidity and mortality (Johns Hopkins University 2020 ), and intensive efforts have been underway to identify treatments and vaccines. Since the acute respiratory distress syndrome due to immune over-response is the deadliest symptom, the 1940s LDIR treatment such as 0.5 Gy X-ray of the lungs (Calabrese and Dhawan 2013 ) has emerged as a promising modality to treat COVID-19 (Algara et al 2020 ; Cosset et al 2020 ; Dhawan et al 2020 ; Kirkby and Mackenzie 2020 ). Fourteen clinical trials are underway worldwide as for Oct 1, 2020 (U.S. National Library of Medicine 2020 ).…”

Section: Medical Treatments That Employ Low Doses Of Ionizing Radiatimentioning

confidence: 99%

Low-dose ionizing radiation as a hormetin: experimental observations and therapeutic perspective for age-related disorders

Vaiserman

Cuttler²,

Socol

2021

Biogerontology

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“…In spite of these limitations, several prospective trials are currently being carried out in the context of the COVID-19 pandemic, encouraged by the lack of effective alternative and the high mortality probability in most severe cases of COVID-19 pneumonia ( Cosset et al, 2020 ; Wilson et al, 2020 ). In addition, the probability that such doses would result in any deterministic toxicity to healthy tissue is very low ( Hanekamp et al, 2020 ).…”

Section: Rationale For Low Dose Irradiation In the Inflammatory Contextmentioning

confidence: 99%

COVID-19-Associated Pneumonia: Radiobiological Insights

et al. 2021

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The evolution of SARS-CoV-2 pneumonia to acute respiratory distress syndrome is linked to a virus-induced “cytokine storm”, associated with systemic inflammation, coagulopathies, endothelial damage, thrombo-inflammation, immune system deregulation and disruption of angiotensin converting enzyme signaling pathways. To date, the most promising therapeutic approaches in COVID-19 pandemic are linked to the development of vaccines. However, the fight against COVID-19 pandemic in the short and mid-term cannot only rely on vaccines strategies, in particular given the growing proportion of more contagious and more lethal variants among exposed population (the English, South African and Brazilian variants). As long as collective immunity is still not acquired, some patients will have severe forms of the disease. Therapeutic perspectives also rely on the implementation of strategies for the prevention of secondary complications resulting from vascular endothelial damage and from immune system deregulation, which contributes to acute respiratory distress and potentially to long term irreversible tissue damage. While the anti-inflammatory effects of low dose irradiation have been exploited for a long time in the clinics, few recent physiopathological and experimental data suggested the possibility to modulate the inflammatory storm related to COVID-19 pulmonary infection by exposing patients to ionizing radiation at very low doses. Despite level of evidence is only preliminary, these preclinical findings open therapeutic perspectives and are discussed in this article.

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Irradiation pulmonaire à faible dose pour l’orage de cytokines du COVID-19 : pourquoi pas ?

Cited by 12 publications

References 18 publications

Immunopathogenesis and treatment of cytokine storm in COVID-19

Immunopathogenesis and treatment of cytokine storm in COVID-19

Low-dose ionizing radiation as a hormetin: experimental observations and therapeutic perspective for age-related disorders

COVID-19-Associated Pneumonia: Radiobiological Insights

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