Low-dose ionizing radiation as a hormetin: experimental observations and therapeutic perspective for age-related disorders

Vaiserman, Alexander; Cuttler, Jerry M.; Socol, Yehoshua

doi:10.1007/s10522-020-09908-5

Cited by 35 publications

(16 citation statements)

References 163 publications

(197 reference statements)

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“…Interestingly, low-dose IR-induced immune hormesis via lncRNAs [ 204 ] occurred in an organ-specific fashion [ 205 ]. In addition, low-dose IR may function as a hormetin in aging by prolonging the lifetime [ 206 ].…”

Section: Ionizing Radiation (Ir) Effects Involving Mitochondriamentioning

confidence: 99%

Role of Mitochondria in Radiation Responses: Epigenetic, Metabolic, and Signaling Impacts

Averbeck

Rodriguez-Lafrasse

2021

IJMS

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Until recently, radiation effects have been considered to be mainly due to nuclear DNA damage and their management by repair mechanisms. However, molecular biology studies reveal that the outcomes of exposures to ionizing radiation (IR) highly depend on activation and regulation through other molecular components of organelles that determine cell survival and proliferation capacities. As typical epigenetic-regulated organelles and central power stations of cells, mitochondria play an important pivotal role in those responses. They direct cellular metabolism, energy supply and homeostasis as well as radiation-induced signaling, cell death, and immunological responses. This review is focused on how energy, dose and quality of IR affect mitochondria-dependent epigenetic and functional control at the cellular and tissue level. Low-dose radiation effects on mitochondria appear to be associated with epigenetic and non-targeted effects involved in genomic instability and adaptive responses, whereas high-dose radiation effects (>1 Gy) concern therapeutic effects of radiation and long-term outcomes involving mitochondria-mediated innate and adaptive immune responses. Both effects depend on radiation quality. For example, the increased efficacy of high linear energy transfer particle radiotherapy, e.g., C-ion radiotherapy, relies on the reduction of anastasis, enhanced mitochondria-mediated apoptosis and immunogenic (antitumor) responses.

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Section: Ionizing Radiation (Ir) Effects Involving Mitochondriamentioning

confidence: 99%

Role of Mitochondria in Radiation Responses: Epigenetic, Metabolic, and Signaling Impacts

Averbeck

Rodriguez-Lafrasse

2021

IJMS

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“…94 Others have presented convincing evidence in support of the hormesis model in great detail. 95 Much of the interpretation of the data used to initially adopt the LNT assumption has been found to be faulty and subject to ideological motivations. 96 For instance, early studies used in support of the LNT assumption about the effects of low radiation doses were shown to actually be relatively high dose exposure levels.…”

Section: Health Risks Of Very Low Level Radiation Diagnostic X-raysmentioning

confidence: 99%

Radiography and Clinical Decision-Making in Chiropractic

Lopes¹,

Coleman²,

Cremata³

2021

Dose-Response

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The concern over x-ray exposure risks can overshadow the potential benefit of radiography, especially in cases where manual therapy is employed. Spinal malalignment cannot be accurately visualized without imaging. Manual therapy and the load tolerances of injured spinal tissues raise different criteria for the use of x-rays for spinal disorders than in medical practice. Current regulatory bodies rely on radiography risk assessments based on Linear-No-Threshold (LNT) risk models. There is a need to consider radiography guidelines for chiropractic which are different from those for medical practice. Radiography practice guidelines are summaries dominated by frequentist interpretations in the analysis of data from studies. In contrast, clinicians often employ a pseudo-Bayesian form of reasoning during the clinical decision-making process. The overrepresentation of frequentist perspectives in evidence-based practice guidelines alter decision-making away from practical assessment of a patient’s needs, toward an overly cautious standard applied to patients without regard to their risk/benefit likelihoods relating to radiography. Guidelines for radiography in chiropractic to fully assess the condition of the spine and spinal alignment prior to manual therapy, especially with high velocity, low amplitude spinal manipulation (HVLA-SM), should necessarily differ from those used in medical practice.

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“…Сучасні дослідження [83][84][85][86][87][88][89][90][91] доводять, що модель радіаційного гормезису, на відміну від моделі LNT, передбачає, що низькі дози радіації спричиняють множинні адаптивні реакції, і такі реакції можуть запобігти певним негативним наслідкам для здоров'я. Що стосується здатності до репарації ДНК, результуючий ефект може залежати від балансу між швидкістю пошкодження ДНК (лінійної дози) та конкретними механізмами, що відповідають за клітинний захист.…”

Section: Eejp 2 (2021)unclassified

“…Горметичні ефекти низьких доз радіації, а також згубні ефекти великих доз та їх вплив на тривалість життя схематично продемонстровані автором [84] на рисунку 3.…”

Section: Eejp 2 (2021)unclassified

Modeling of Molecular Mechanisms of Radiation Adaptive Response Formation

2021

EEJP

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The phenomenon of adaptive response is expressed in the increase of resistance of a biological object to high doses of mutagens under the conditions of previous exposure to these (or other) mutagens in low doses. Low doses of mutagen activate a number of protective mechanisms in a living object, which are called hormetic. Thus, the adaptive response and hormesis are links in the same chain. Radiation hormesis refers to the generally positive effect of low doses of low LET radiation on biological objects. The phenomenology of radiation-induced adaptive response and radiation hormesis for biological objects of different levels of organization is considered; the review of existing theories describing the dose-effect relationship has been reviewed. The hypothesis proposing one of the mechanisms of formation of radiation adaptive response of cells taking into account the conformational structure of chromatin has been submitted. The analysis of modern concepts of the phenomenon of hormesis on the basis of modeling of molecular mechanisms of formation of hormetic reactions to low-dose low LET radiation has been carried out. The parameters that can be used for quantitative and graphical evaluation of the phenomenon of hormesis was considered, and a formula for calculating the coefficient of radiation-induced adaptive response has been proposed. A review of mathematical models describing the radiation relative risk of gene mutations and neoplastic transformations at low-dose irradiation of cohorts has been performed. The following conclusions have been made: radiation hormesis and adaptive response are generally recognized as real and reproducible biological phenomena, which should be considered as very important phenomena of evolutionarily formed biological protection of living organisms from ionizing radiation. The hormesis model of dose-response relationship makes much more accurate predictions of a living object's response to radiation (or other stressors) in the low-dose range than the linear threshold (LNT) model does. The LNT model can adequately describe reactions only in the region of high doses of radiation, and, therefore, extrapolation modeling of biological object’s reactions from the zone of high doses to low doses is not correct.

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Low-dose ionizing radiation as a hormetin: experimental observations and therapeutic perspective for age-related disorders

Cited by 35 publications

References 163 publications

Role of Mitochondria in Radiation Responses: Epigenetic, Metabolic, and Signaling Impacts

Role of Mitochondria in Radiation Responses: Epigenetic, Metabolic, and Signaling Impacts

Radiography and Clinical Decision-Making in Chiropractic

Modeling of Molecular Mechanisms of Radiation Adaptive Response Formation

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