RNA functionalized singled-walled carbon nanotube devices for chemical sensing

Liu, Y.; Chen, M.; Wang, M. L.; Dokmeci, Mehmet R.

doi:10.1063/1.4819723

Cited by 5 publications

(3 citation statements)

References 19 publications

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“…Moreover, CNTs can be arranged into structures with dimensions ranging from the subcellular to multicellular scale by self-organized CNT synthesis or post-synthesis assembly. The surfaces of CNTs can be functionalized with organic and inorganic molecules [2][3][4], and with RNA [5,6] or DNA [7], which may be chosen to present favorable chemical interfaces to biological tissues. For these reasons, researchers have widely explored CNTs as probes for inter-and intra-cellular stimulation and recording of neuronal signals [8,9].…”

Section: Introductionmentioning

confidence: 99%

Growth of primary motor neurons on horizontally aligned carbon nanotube thin films and striped patterns

et al. 2014

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Section: Introductionmentioning

confidence: 99%

Growth of primary motor neurons on horizontally aligned carbon nanotube thin films and striped patterns

et al. 2014

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“…ssDNA-decorated, individually semiconducting SWCNTs in a field-effect transistor (FET) configuration merge the molecular recognition diversity of ssDNA with the excellent electronic properties of SWCNT to provide a fast electronic platform for biosensing [ 14 ]. Previously, numerous works have demonstrated that nucleic acid-functionalized CNT-based FETs exhibit fast, specific, and reproducible response to the detection of various polar molecules [ 15 – 16 ].…”

Section: Introductionmentioning

confidence: 99%

Sequence-dependent electrical response of ssDNA-decorated carbon nanotube, field-effect transistors to dopamine

Mohan¹,

An²,

Zheng³

2014

Beilstein J. Nanotechnol.

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SummarySingle-walled carbon nanotube (SWCNT)-based field-effect transistors (FETs) have been explored for use as biological/chemical sensors. Dopamine (DA) is a biomolecule with great clinical significance for disease diagnosis, however, SWCNT FETs lack responsivity and selectivity for its detection due to the presence of interfering compounds such as uric acid (UA). Surface modification of CNTs using single-stranded deoxyribonucleic acid (ssDNA) renders the surface responsive to DA and screens the interferent. Due to the presence of different bases in ssDNA, it is necessary to investigate the effect of sequence on the FET-based molecular recognition of DA. SWCNT FETs were decorated with homo- and repeated-base ssDNA sequences, and the electrical response induced by DA in the presence and absence of UA was gauged in terms of the variation in transistor electrical parameters including conductance, transconductance, threshold voltage and hysteresis gap. Our results showed that the response of ssDNA-decorated devices to DA, irrespective of the presence or absence of UA, was DNA sequence dependent and exhibited the trend: G > A > C and GA > GT > AC > CT, for homo- and repeated-base sequences, respectively. The different response of various SWCNT–ssDNA systems to DA underlines the sequence selectivity, whereas the detection of DA in the presence of UA highlights the molecular selectivity of the ssDNA-decorated devices.

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“…Thus, ssDNA-decorated SWCNT FET creates a sensing platform, which can be tuned using selective ssDNA sequences to detect a plethora of aqueous and vapour-phase target analytes with a high level of chemical diversity. 13,179,180 The electrical transistor parameters including conductance, transconductance, threshold voltage and hysteresis gap, which are indicators of the contributing sensing mechanisms, 7 aid in interpreting the sequence dependent response. Therefore, the variation in transistor parameters obtained from the currentvoltage characteristics due to ssDNA-DA interaction will facilitate the design of ssDNA sequences for sensitive and selective detection of a DA.…”

Section: Effect Of Channel Lengthmentioning

confidence: 99%

Carbon nanotube based electronic detection of biomolecules and chemicals

Krishna¹

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First and foremost, I would like to thank my ex-supervisor, Prof. Zheng Lianxi, for giving me an opportunity to embark on this journey of PhD in the area of nanotechnology. These four years have undoubtedly been the toughest phase of my life as I kept encountering several hurdles both personally and academically. Nevertheless, every time I look up to Prof. Zheng, he has given me priceless suggestions, constant encouragement, and timely guidance, which have largely been the source of my strength during these strenuous phases. Prof. Zheng has been a true role model for me for his simple attitude towards work and life. I am deeply indebted to him, and without his guidance, I would not have been able to improve in various aspects of research and life. I also sincerely thank my current supervisor Prof. Wong Chee How, who has been instrumental in my thesis submission process following Prof. Zheng's departure from NTU. He has been kind and I am extremely grateful to him for lending a helping hand in my troubled times.

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RNA functionalized singled-walled carbon nanotube devices for chemical sensing

Cited by 5 publications

References 19 publications

Growth of primary motor neurons on horizontally aligned carbon nanotube thin films and striped patterns

Growth of primary motor neurons on horizontally aligned carbon nanotube thin films and striped patterns

Sequence-dependent electrical response of ssDNA-decorated carbon nanotube, field-effect transistors to dopamine

Carbon nanotube based electronic detection of biomolecules and chemicals

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