Growth of primary motor neurons on horizontally aligned carbon nanotube thin films and striped patterns

Roberts, Michael M.; Leach, Michelle K.; Bedewy, Mostafa; Meshot, Eric R.; Copic, Davor; Corey, Joseph M.; Hart, A. J.

doi:10.1088/1741-2560/11/3/036013

Cited by 19 publications

(10 citation statements)

References 59 publications

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“…Based on the physical dimension of the cell body, neurite, and growth cone, numerous studies have been conducted to examine the interaction of neurons and surface micropatterns with comparable dimensions. These surface micropatterns include beads, electrospun fibers, nanotubes, pillars, ridges/grooves/gratings, or nanorough surfaces . However, most of these in vitro studies focus on the interaction of surface topography with uninjured neurons.…”

Section: Introductionmentioning

confidence: 99%

Nanoimprinted Anisotropic Topography Preferentially Guides Axons and Enhances Nerve Regeneration

Huang

Lin

et al. 2018

Macromolecular Bioscience

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Surface topography has a profound effect on the development of the nervous system, such as neuronal differentiation and morphogenesis. While the interaction of neurons and the surface topography of their local environment is well characterized, the neuron–topography interaction during the regeneration process remains largely unknown. To address this question, an anisotropic surface topography resembling linear grooves made from poly(ethylene‐vinyl acetate) (EVA), a soft and biocompatible polymer, using nanoimprinting, is established. It is found that neurons from both the central and peripheral nervous system can survive and grow on this grooved surface. Additionally, it is observed that axons but not dendrites specifically align with these grooves. Furthermore, it is demonstrated that neurons on the grooved surface are capable of regeneration after an on‐site injury. More importantly, these injured neurons have an accelerated and enhanced regeneration. Together, the data demonstrate that this anisotropic topography guides axon growth and improves axon regeneration. This opens up the possibility to study the effect of surface topography on regenerating axons and has the potential to be developed into a medical device for treating peripheral nerve injuries.

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Section: Introductionmentioning

confidence: 99%

Nanoimprinted Anisotropic Topography Preferentially Guides Axons and Enhances Nerve Regeneration

Huang

Lin

et al. 2018

Macromolecular Bioscience

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“…In addition to providing a permissive substrate for neuronal growth, patterned CNT substrates are also able to control the direction of neurite outgrowth . Zhang et al reported directed neurite outgrowth of the H19‐7 hippocampal cell line by poly L ‐lysine (PLL) coated multi‐walled carbon nanotube (MWCNT) arrays (Figure c).…”

Section: Cnts: Potential Role In Nerve Repairmentioning

confidence: 99%

Repairing Peripheral Nerves: Is there a Role for Carbon Nanotubes?

Oprych

Whitby

Mikhalovsky

et al. 2016

Adv Healthcare Materials

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Peripheral nerve injury continues to be a major global health problem that can result in debilitating neurological deficits and neuropathic pain. Current state‐of‐the‐art treatment involves reforming the damaged nerve pathway using a nerve autograft. Engineered nerve repair conduits can provide an alternative to the nerve autograft avoiding the inevitable tissue damage caused at the graft donor site. Commercially available nerve repair conduits are currently only considered suitable for repairing small nerve lesions; the design and performance of engineered conduits requires significant improvements to enable their use for repairing larger nerve defects. Carbon nanotubes (CNTs) are an emerging novel material for biomedical applications currently being developed for a range of therapeutic technologies including scaffolds for engineering and interfacing with neurological tissues. CNTs possess a unique set of physicochemical properties that could be useful within nerve repair conduits. This progress report aims to evaluate and consolidate the current literature pertinent to CNTs as a biomaterial for supporting peripheral nerve regeneration. The report is presented in the context of the state‐of‐the‐art in nerve repair conduit design; outlining how CNTs may enhance the performance of next generation peripheral nerve repair conduits.

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“…For instance, polymer-based porous fi lms physically or chemically loaded with neurotrophic factors with surface gradients and surface nano/micropatterning have been used as conduits for neural regeneration . The different types of scaffolds bearing surface nano/micropatterning have also been shown to provide topographic guidance cues to create regenerative platforms for cells (Roberts et al 2014 ;Ho et al 2015 ;McMurtrey 2014 ;Houchin-Ray et al 2007 ;Rutkowski et al 2004 ). Miller and coworkers (Miller et al 2001a , b ) prepared biodegradable micropatterned poly( D , L -lactic acid) fi lms using solvent casting and showed that such fi lms are capable of enhancing the alignment of Schwann cells, indirectly increasing neurite length and orientation of DRG cells growing along with the aligned Schwann cells.…”

Section: Other Types Of Scaffoldsmentioning

confidence: 99%

Neural Engineering

2016

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Growth of primary motor neurons on horizontally aligned carbon nanotube thin films and striped patterns

Cited by 19 publications

References 59 publications

Nanoimprinted Anisotropic Topography Preferentially Guides Axons and Enhances Nerve Regeneration

Nanoimprinted Anisotropic Topography Preferentially Guides Axons and Enhances Nerve Regeneration

Repairing Peripheral Nerves: Is there a Role for Carbon Nanotubes?

Neural Engineering

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