Neural Engineering

doi:10.1007/978-3-319-31433-4

Cited by 10 publications

(1 citation statement)

References 932 publications

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“…There is further evidence showing the great influence of an ES on growth and development of nerve cells, wound healing, and angiogenesis, among other cellular properties, the former being one of the most relevant in this field [68]. In addition, by means of controlled ES, a greater cellular differentiation is achieved; for instance, stem cell differentiation to neurons [33,68,69]. One of the main effect of ES is the opening of ion channels, triggering the production of ions that can be deposited on tissues [70].…”

Section: Polymers For Tissue Engineering Through Electrostimulatiomentioning

confidence: 99%

Electroactive Smart Polymers for Biomedical Applications

2019

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The flexibility in polymer properties has allowed the development of a broad range of materials with electroactivity, such as intrinsically conductive conjugated polymers, percolated conductive composites, and ionic conductive hydrogels. These smart electroactive polymers can be designed to respond rationally under an electric stimulus, triggering outstanding properties suitable for biomedical applications. This review presents a general overview of the potential applications of these electroactive smart polymers in the field of tissue engineering and biomaterials. In particular, details about the ability of these electroactive polymers to: (1) stimulate cells in the context of tissue engineering by providing electrical current; (2) mimic muscles by converting electric energy into mechanical energy through an electromechanical response; (3) deliver drugs by changing their internal configuration under an electrical stimulus; and (4) have antimicrobial behavior due to the conduction of electricity, are discussed.

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Section: Polymers For Tissue Engineering Through Electrostimulatiomentioning

confidence: 99%

Electroactive Smart Polymers for Biomedical Applications

2019

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3D Bioprinting for Organ Regeneration

Cui

Nowicki

Fisher

et al. 2016

Adv Healthcare Materials

430

392

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Regenerative medicine holds the promise of engineering functional tissues or organs to heal or replace abnormal and necrotic tissues/organs, offering hope for filling the gap between organ shortage and transplantation needs. Three-dimensional (3D) bioprinting is evolving into an unparalleled bio-manufacturing technology due to its high-integration potential for patient-specific designs, precise and rapid manufacturing capabilities with high resolution, and unprecedented versatility. It enables precise control over multiple compositions, spatial distributions, and architectural accuracy/complexity, therefore achieving effective recapitulation of microstructure, architecture, mechanical properties, and biological functions of target tissues and organs. Here we provide an overview of recent advances in 3D bioprinting technology, as well as design concepts of bioinks suitable for the bioprinting process. We focus on the applications of this technology for engineering living organs, focusing more specifically on vasculature, neural networks, the heart and liver. We conclude with current challenges and the technical perspective for further development of 3D organ bioprinting.

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Regeneration of the peripheral nerve via multifunctional electrospun scaffolds

Ghane

Khalili

Khorasani

et al. 2020

J Biomedical Materials Res

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Over the last two decades, electrospun scaffolds have proved to be advantageous in the field of nerve tissue regeneration by connecting the cavity among the proximal and distal nerve stumps growth cones and leading to functional recovery after injury. Multifunctional nanofibrous structure of these scaffolds provides enormous potential by combining the advantages of nano‐scale topography, and biological science. In these structures, selecting the appropriate materials, designing an optimized structure, modifying the surface to enhance biological functions and neurotrophic factors loading, and native cell‐like stem cells should be considered as the essential factors. In this systematic review paper, the fabrication methods for the preparation of aligned nanofibrous scaffolds in yarn or conduit architecture are reviewed. Subsequently, the utilized polymeric materials, including natural, synthetic and blend are presented. Finally, their surface modification techniques, as well as, the recent advances and outcomes of the scaffolds, both in vitro and in vivo, are reviewed and discussed.

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Neural Engineering

Cited by 10 publications

References 932 publications

Electroactive Smart Polymers for Biomedical Applications

Electroactive Smart Polymers for Biomedical Applications

3D Bioprinting for Organ Regeneration

Regeneration of the peripheral nerve via multifunctional electrospun scaffolds

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