Risks to aquatic organisms posed by human pharmaceutical use

Kostich, Mitchell S.; Lazorchak, James M.

doi:10.1016/j.scitotenv.2007.09.008

Cited by 182 publications

(119 citation statements)

References 47 publications

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“…For diclofenac, the LOEC for fish toxicity was in the range of wastewater concentrations, whereas the LOEC of propanolol and fluoxetine for zooplankton and benthic organisms were near to maximal effluent concentrations. Kostich and Lazorchak (2008) used a simple approach, prioritising pharmaceuticals using marketing data and predicted concentrations of likely activity in wastewater to evaluate the risk to aquatic organisms using PECs. This approach was extended by comparison with regulatory data (Kostich et al, 2010).…”

Section: Risk Assessmentmentioning

confidence: 99%

Review of risk from potential emerging contaminants in UK groundwater

Stuart

Lapworth

Crane

et al. 2012

Science of The Total Environment

636

284

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This paper provides a review of the types of emerging organic groundwater contaminants (EGCs) which are beginning to be found in the UK. EGCs are compounds being found in groundwater that were previously not detectable or known to be significant and can come from agricultural, urban and rural point sources. EGCs include nanomaterials, pesticides, pharmaceuticals, industrial compounds, personal care products, fragrances, water treatment by-products, flame retardants and surfactants, as well as caffeine and nicotine. Many are relatively small polar molecules which may not be effectively removed by drinking water treatment. Data from the UK Environment Agency's groundwater screening programme for organic pollutants found within the 30 most frequently detected compounds a number of EGCs such as pesticide metabolites, caffeine and DEET. Specific determinands frequently detected include pesticides metabolites, pharmaceuticals including carbamazepine and triclosan, nicotine, food additives and alkyl phosphates. This paper discusses the routes by which these compounds enter groundwater, their toxicity and potential risks to drinking water and the environment. It identifies challenges that need to be met to minimise risk to drinking water and ecosystems.

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Section: Risk Assessmentmentioning

confidence: 99%

Review of risk from potential emerging contaminants in UK groundwater

Stuart

Lapworth

Crane

et al. 2012

Science of The Total Environment

636

284

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“…With the popularity of recreational fishing in watersheds downstream from the investigated WWTP, medical personnel may expect more aeromonad-related infections, whereas their diagnosis and treatment may be difficult, particularly taking into consideration the emerging antibiotic resistance of fish pathogens. Environmental contamination with antimicrobials and other antibiotic substances is an important contributor to the survival and spread of antibiotic resistance genes (Huddleston et al, 2006), particularly through spread of resistance plasmids between unrelated bacteria (Kostich and Lazorchak, 2008).…”

Section: Water Qualitymentioning

confidence: 99%

Impact of treated wastewater on organismic biosensors at various levels of biological organization

Popović

Strunjak‐Perović

Klobučar

et al. 2015

Science of The Total Environment

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Relating the treated wastewater quality and its impact on organismic biosensors (Prussian carp, Carassius gibelio and earthworm, Eisenia fetida) was the main objective of the study. The impact on health status of fish living downstream, microbiological contamination and antimicrobial resistance, fish tissue structure, blood biochemistry, oxidative stress, genotoxic effects, as well as multixenobiotic resistance mechanism (MXR) was assessed. Treated wastewater discharged from the WWTP modified the environmental parameters and xenobiotic concentrations of the receiving surface waters. Potential bacterial pathogens from fish and respective waters were found in relatively low numbers, although they comprised aeromonads with a zoonotic potential. High resistance profiles were determined towards the tested antimicrobial compounds, mostly sulfamethoxazole and erytrhomycin. Histopathology primarily revealed gill lamellar fusion and reduction of interlamellar spaces of effluent fish. A significant increase in plasma values of urea, total proteins, albumins and triglycerides and a significant decrease in the activity of plasma superoxide dismutase were noted in carp from the effluent-receiving canal. Micronucleus test did not reveal significant differences between the examined groups, but a higher frequency of erythrocyte nuclear abnormalities was found in fish sampled from the effluent-receiving canal. Earthworms indicated to the presence of MXR inhibitors in water and sludge samples, thus proving as a sensitive sentinel organism for environmental pollutants. The integrative approach of this study could serve as a guiding principle in conducting evaluations of the aquatic habitat health in complex bio-monitoring studies.Response to Reviewers: The response is attached as a separate file. We request that this manuscript be considered for publication in Science of the Total Environment as an original, full paper. This manuscript has not been published and is not under consideration for publication in any other journal. All authors concur with the submission.The manuscript is a result of a comprehensive study which integrated various disciplines and research fields. The authors decided to present it as a whole rather than splitting it in two or more papers, for a better understanding of the discussed subject. We believe we have presented a potential guiding principle for conducting evaluations of the aquatic habitat health in complex bio-monitoring studies.I will be serving as the corresponding author for the manuscript. We hope that it is found to be interesting and appropriate for publication in Science of the Total Environment. Should you have any questions, please do not hesitate to contact me.Yours truly, Natalija Topic Popovic, DVM, PhD Response: Thank you for this clarification. We have taken a whole different approach and completely rewritten all sections relating to the PCA as they were indeed confusing, and created a new biplot for plasma parameters. We hope that the new text, as inserted in the respect...

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“…Already, in several areas of the world, this is beginning to take place. The comparison of predicted antibacterial concentrations to published minimum inhibitory concentrations suggests that antibacterials in wastewaterbut probably not antifungals -may select for low-level antibacterial resistance (Kostich & Lazorchak, 2008). Also, the presence of R-factor-infected populations of bacteria in aquaculture systems may lead to the transfer of antibacterial resistance to other micro-organisms, including potential human pathogens (Roberts, 2004;Cabello, 2006).…”

Section: Resistance Of Aquatic Bacteriamentioning

confidence: 99%

Antibacterial Drugs in Fish Farms: Application and Its Effects

Sekkin¹,

Kum²

2011

Recent Advances in Fish Farms

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The world keeps changing. There are always risks associated with change. To make careful risk assessment it is always needed to re-evaluate the information according to new findings in research. Scientific knowledge is essential in determining the strategy for fish farming. This information should be updated and brought into line with the required conditions of the farm. Therefore, books are one of the indispensable tools for following the results in research and sources to draw information from. The chapters in this book include photos and figures based on scientific literature. Each section is labeled with references for readers to understand, figures, tables and text. Another advantage of the book is the "systematic writing" style of each chapter. There are several existing scientific volumes that focus specially on fish farms. The book consists of twelve distinct chapters. A wide variety of scientists, researchers and other will benefit from this book.

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Risks to aquatic organisms posed by human pharmaceutical use

Cited by 182 publications

References 47 publications

Review of risk from potential emerging contaminants in UK groundwater

Review of risk from potential emerging contaminants in UK groundwater

Impact of treated wastewater on organismic biosensors at various levels of biological organization

Antibacterial Drugs in Fish Farms: Application and Its Effects

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