Risk of dysplasia in anal condyloma

Metcalf, Amanda M.; Dean, Thomas

doi:10.1016/s0039-6060(05)80041-8

Cited by 53 publications

(31 citation statements)

References 13 publications

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“…2 They are refractory to conventional therapy 2,8 and associated with a high incidence of recurrence, 8,9 and there is high-grade dysplasia in 30 percent of patients. 5,6,[10][11][12][13][14][15] Progression from in situ to invasive carcinoma also has been described, 11 occurring in most cases at the anal canal transitional zone. 16 Some features of the disease have been associated with the increased probability of developing dysplasia in anal condylomata: anal intercourse and HIV seropositivity, 10,12,14,17 immunodeficiency, 18 advanced HIV-infection status, 4 warts above the dentate line, 14 T CD4ϩ lymphocyte counts of Ͻ500/ mm 3 , 13,18-21 and HPV type.…”

mentioning

confidence: 99%

Postoperative Follow-Up of Anal Condylomata Acuminata in HIV-Positive Patients

Manzione¹,

Nadal²,

Calore³

2003

Diseases of the Colon &Amp; Rectum

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confidence: 99%

Postoperative Follow-Up of Anal Condylomata Acuminata in HIV-Positive Patients

Manzione¹,

Nadal²,

Calore³

2003

Diseases of the Colon &Amp; Rectum

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“…2,3 Moreover, this group of patients tends to develop pre-malignant anal lesions, known as anal intraepithelial neoplasia (AIN), mainly among male homosexuals. 4 In addition to this, we noticed in another study that patients with high-grade AIN (HAIN) had more wart recurrence than patients with condylomas without HAIN. 5 Factors involved in AIN development and the high incidence of condyloma recurrence in these patients are still not completely clarified.…”

Section: Introductionmentioning

confidence: 72%

“…4,5 Some others have shown a high frequency of HPV infection, as with pre-neoplastic lesions in cervical epithelium in HIV positive women. [13][14][15][16][17] Moreover, HIV+ women have more risks for cervical cancer than HIV negative women.…”

Section: Discussionmentioning

confidence: 99%

Ki-67 expression in anal intraepithelial neoplasia in AIDS

et al. 2001

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CONTEXT: AIDS is one of the most important risk factors for progression and recurrence of anogenital condyloma. In a previous work, we observed that patients with warts and high-grade AIN (HAIN) had recurrences more frequently than did patients with warts without AIN. The mechanisms of this increased incidence of high-grade lesions in AIDS are not known. OBJECTIVE: We studied the expression of the proliferative marker Ki-67 by immunohistochemical methods, in specimens of anal condyloma from HIV+ patients to clarify whether its expression can be associated to the grade of AIN. DESIGN: A retrospective study of hiltological specimens. SETTING: University referral unit. SAMPLE: 34 patients were divided into two groups: (1) condylomas with low grade AIN (LAIN), with 25 patients; and (2) condylomas with HAIN, with 9 patients. In this latter group we examined two areas: 2A (HAIN area) and 2B (LAIN area). MAIN MEASUREMENTS: The immunohistochemical reaction for Ki-67 was done on histological sections. Slices were lightly stained with hematoxylin, to help us in Ki-67 positive cell counting. The percentage of Ki-67 marked nuclei was calculated. We applied one-way variance analysis for statistics. RESULTS: The mean number of Ki-67 positive cells in group 1 was 19.68 ± 10.99; in group 2 (area A) it was 46.73 ± 10.409; and in area B it was 36.43 ± 14.731. There were statistical differences between groups 1 and 2A and between groups 1 and 2B. Ki-67 positive cells predominated in the lower layer in LAIN. Positive Ki-67 cells were found in all layers in group 2A, and in group 2B they predominated in the two lower or in all layers of the epithelium. CONCLUSIONS: Our results suggest that LAIN areas (using routine staining techniques) in HAIN can have a biological behavior more similar to HAIN.

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“…9,13,[19][20][21] A recidiva dos condilomas acuminados anais ocorre entre 4% e 84% dos doentes independentemente do tipo de tratamento realizado, não havendo um tratamento mais indicado para pacientes com HIV e verrugas anais. [22][23][24] Optamos por adotar o tratamento proposto por Nadal e col 12 , onde inicialmente é realizado o tratamento tópico o que proporciona a redução no tamanho dos condilomas, tornando a ressecção cirúrgica mais fácil 12,15 . Além disso, a utilização de medicação tópica prévia pode prolongar o período sem recidivas.…”

Section: Resultsunclassified

Recidiva de lesões associadas ao HPV em pacientes HIV positivos após tratamento cirúrgico

Pincinato

Horta

Filho

et al. 2009

Rev bras. colo-proctol.

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RESUMO: O HPV é a doença anal sexualmente transmissível mais diagnosticada em pacientes HIV positivos. Neste estudo investigamos a taxa de recidiva após tratamento cirúrgico do HPV em pacientes HIV positivos. Foi realizado um estudo retrospecA transmissão é comumente por relação sexual, e é estimado que mais de 50% das pessoas sexualmente ativas tenham sido infectadas por HPV em algum momento de suas vidas.5 O acometimento anal é comum e predomina em grupos com comportamento de risco para DST, antecedentes de tratamento de HPV genital ou anal prévio e portadores de prurido anal idiopático.1,6-9 O HPV também pode ser transmitido por via oral, manual ou vestimentas, pela proximidade com os genitais. 6,10,11 A maioria das infecções por HPV são assintomáticas, sendo que apenas 10% dos pacientes desenvolverão lesões verrucosas ou displasias.3,12,13 Em pacientes HIV positivos, as manifestações anogenitais são mais agressivas e com maior número de recidivas. 3,10,[12][13][14] O grau de imunidade dos pacientes, o vírus HIV e a agressividade viral estão relacionados a maiores taxas de prevalência, severidade, persistência e recidiva no tratamento do HPV. 15,16 O objetivo desse estudo é avaliar a recidiva de lesões associadas ao HPV anal em pacientes HIV positivos após tratamento cirúrgico.

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Risk of dysplasia in anal condyloma

Cited by 53 publications

References 13 publications

Postoperative Follow-Up of Anal Condylomata Acuminata in HIV-Positive Patients

Postoperative Follow-Up of Anal Condylomata Acuminata in HIV-Positive Patients

Ki-67 expression in anal intraepithelial neoplasia in AIDS

Recidiva de lesões associadas ao HPV em pacientes HIV positivos após tratamento cirúrgico

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