Risk of community-acquired pneumonia in chronic obstructive pulmonary disease stratified by smoking status: a population-based cohort study in the United Kingdom

Braeken, Dionne C.W.; Rohde, Gernot; Franssen, Frits M.E.; Driessen, Johanna H M; Staa, Tjeerd van; Souverein, Patrick C.; Wouters, Emiel F.M.; Vries, Frank de

doi:10.2147/copd.s138435

Cited by 25 publications

(22 citation statements)

References 54 publications

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“…We would like to thank Shukla et al for their interesting and valuable addition to our study, which showed that the risk of community-acquired pneumonia (CAP) was fourfold increased among patients with COPD, regardless of their smoking status. 1 They first speculate that their observation of expression of adhesion molecules (PAFr) in several bacteria that can cause CAP among COPD patients may explain our findings. Although they observed a significantly increased expression of PAFr among smokers with COPD versus smokers with a normal lung function, PAFr expression was not elevated among COPD patients who were ex-smokers.…”

mentioning

confidence: 73%

“…We read with great interest the recent paper by Braeken et al which analyzed the associations between COPD and community-acquired pneumonia (CAP), published in your journal. 1 In this large population-based study, the authors have concluded that the risk of CAP increases fourfold in patients with COPD, independent of smoking status. The authors briefly discuss potential smoking-induced mechanisms leading to increased risk of CAP in COPD, such as host physiological and structural changes, increased bacterial virulence and impaired host immunity.…”

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confidence: 96%

“…The authors also stress the need for further mechanistic studies on the cause of this increased risk of CAP in COPD patients. 1 …”

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confidence: 99%

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Upregulated pneumococcal adhesion molecule (platelet-activating factor receptor) may predispose COPD patients to community-acquired pneumonia

Shukla¹,

Hansbro²,

Walters³

2017

COPD

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confidence: 73%

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confidence: 96%

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Upregulated pneumococcal adhesion molecule (platelet-activating factor receptor) may predispose COPD patients to community-acquired pneumonia

Shukla¹,

Hansbro²,

Walters³

2017

COPD

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“…An analysis of covariance (ANCOVA) was performed to examine the association between pneumonia and the albumin level. We adjusted for potential confounders, including age (continuous variable) (1,8), consciousness level (continuous variable) (18), tube feeding (no or yes) (5,8), mechanical ventilation (no or yes) (19), and pulmonary disease (no or yes) (7,20,21). These variables were additionally entered into models (Models 1-5) (22).…”

Section: Discussionmentioning

confidence: 99%

Effects of Nutritional Treatment on the Frequency of Pneumonia in Bedridden Patients Receiving Oral Care

et al. 2020

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Objective Pneumonia develops in bedridden patients, even in those receiving oral care, and malnutrition is associated with the development of pneumonia. We examined the effects of nutritional treatment on the prevention of pneumonia. Patients and MethodsWe retrospectively examined the effects of nutritional treatment on the prevention of pneumonia by analyzing the records of bedridden patients (n=68; mean age: 68.0 years) who stayed in a hospital for 2 years or longer. Results Among the analyzed patients, pneumonia developed in 52 (76%) patients, and the mean frequency of pneumonia was 1.6 times per year during the first year of stay. In a multivariate analysis, the serum albumin level at admission in the pneumonia group was lower than that in the non-pneumonia group. The frequency of pneumonia during the second year of stay was lower than that during the first year of stay. Serum levels of albumin and total protein (TP) at one year after admission were higher than those at admission in all analyzed patients, and in all patients (n=52) and elderly (! 65 years) patients (n=31) in the pneumonia group. The proportions of patients with hypoalbuminemia (<3.5 g/dL) and hypoproteinemia (<6.5 g/dL) at one year after admission were lower than those at admission. The increases in the proportions of patients presenting a reduced frequency of pneumonia were correlated with increases in the proportions of patients presenting increased levels of albumin and/or TP. Conclusion Nutritional treatment may reduce the frequency of pneumonia by improving malnutrition in bedridden patients receiving oral care.

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“…Asap rokok dapat mengganggu kerja klirens mukosilier, merubah struktur dan mengganggu imun lokal pada saluran napas sehingga memudahkan bakteri untuk masuk ke dalam parenkim paru meningkatkan risiko terjadinya pneumonia komunitas. 22 Indikator perbaikan klinis ≤5 hari didapatkan pada 122 pasien (80,8%) dan 29 pasien (19,2%) >5 hari. Lama perawatan pasien dalam penelitian ini adalah 5 hari sesuai dengan pedoman IDSA/ATS bahwa pasien dengan pneumonia komunitas harus dirawat minimal selama 5 hari dan harus bebas demam selama 48-72 jam.…”

Section: Diskusiunclassified

Hubungan Antara Ketepatan Pemberian Antibiotik Berdasarkan Alur Gyssens dengan Perbaikan Klinis Pasien pada Pneumonia Komunitas

Rumende¹,

Chen²,

Karuniawati³

et al. 2019

JPDI

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Pendahuluan. Ketepatan pemberian antibiotik dapat meningkatkan keberhasilan terapi pada pneumonia komunitas dan mencegah timbulnya resistensi bakteri terhadap berbagai macam antibiotik. Community-acquired pneumonia (CAP) masih banyak ditemukan di Indonesia dengan angka insiden 2,4%. Tujuan penelitian ini adalah untuk menilai ketepatan pemilihan antibiotik pada CAP dengan menggunakan alur Gyssens yang diberikan berdasarkan panduan IDSA-ATS 2007, serta hubungannya dengan respons klinis pasien.Metode. Penelitian ini merupakan penelitian kohort retrospektif dengan menggunakan data sekunder dari data penelitian sebelumnya. Penelitian dilaksanakan pada tiga rumah sakit di Jakarta yaitu RS Cipto Mangunkusumo, RSUD Budhi Asih dan RSPAD Gatot Subroto selama periode bulan September 2016 hingga November 2017.Hasil. Pada penelitian ini, dari 151 pasien yang mendapat antibiotik pertama yang diberikan secara monoterapi, pemberian yang tepat dengan kategori 0 dan 1 didapatkan sebanyak 38 pasien (25,2%). Untuk pemberian antibiotik yang tidak tepat (kategori II-V) didapatkan sebanyak 113 pasien (74,8%) yang sebagian besar karena pemberian yang terlalu singkat (kategori III-b), yaitu pada 51 pasien (33,8%). Untuk antibiotik kedua yang diberikan secara kombinasi, pemberian yang tepat didapatkan pada 15 pasien (9,9%). Uji hubungan antara ketepatan pemberian antibiotik pertama dengan perbaikan klinis pada CAP mendapatkan nilai RR=0,970 (interval kepercayaan [IK] 95%: 0,80 – 1,16); nilai p=0,738. Sementara pada antibiotik kedua didapatkan nilai RR=1,194 (IK 95%: 0,648 – 2,20); nilai p=1,00. Dengan demikian, tidak didapatkan adanya hubungan yang bermakna antara ketepatan pemberian kedua antibiotik tersebut pada CAP yang dinilai berdasarkan alur Gyssens dengan perbaikan klinis pasien.Simpulan. Tidak didapatkan adanya hubungan yang bermakna antara ketepatan pemberian antibiotik pada CAP yang dinilai berdasarkan alur Gyssens dengan perbaikan klinis pasien. Kata Kunci: Alur Gyssens, CAP, Perbaikan klinis, Terapi antibiotik Correlation between Proper Antibiotics Administration to Community Acquired Pneumonia Patients Based on Alur Gyssens with Clinical ResponseIntroduction. The proper of antibiotics treatment will increase the improvement of the patient with community-acquired pneumonia (CAP) and also counteract antimicrobial resistance. Community-Acquired Pneumonia is commonly found in Indonesia with an incidence of 2.4%. This study aimed to determine the proper of antibiotic selection for CAP based on IDSA-ATS 2007 guidelines with Gyssens method and evaluate the relationship between the proper of antibiotic treatment with the clinical response of patients. Methods. A retrospective cohort study was conducted with secondary data from the previous study. Study was conducted in three hospitals in Jakarta, namely Cipto Mangunkusumo General Hospital, Budhi Asih Hospital, and Gatot Subroto Hospital between September 2016 and November 2017.Results. From 151 patients, the appropriate of the first antibiotic treatment, including category 0 and 1 was found in 38 patients (25.2%), while for inappropriate one (category II-V) was in 113 patients (74.8%) mainly due too short antibiotic treatment. For the second antibiotic given to 54 patients, appropriate treatment was found in 15 patients (9.9%). There was no correlation between the accuracy of both antibiotics treatment in CAP based on Gyssens method with clinical response of the patients (first antibiotic treatment: RR=0,970 (95% CI: 0,80 – 1,16), p=0,738; second antibiotic treatment: RR=1,194 (95% CI: 0,648 – 2,20), p=1,00).Conclusion. There was no correlation between the accuracy of antibiotics treatment in CAP based on Gyssens method with clinical response of the patients.

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Risk of community-acquired pneumonia in chronic obstructive pulmonary disease stratified by smoking status: a population-based cohort study in the United Kingdom

Cited by 25 publications

References 54 publications

Upregulated pneumococcal adhesion molecule (platelet-activating factor receptor) may predispose COPD patients to community-acquired pneumonia

Upregulated pneumococcal adhesion molecule (platelet-activating factor receptor) may predispose COPD patients to community-acquired pneumonia

Effects of Nutritional Treatment on the Frequency of Pneumonia in Bedridden Patients Receiving Oral Care

Hubungan Antara Ketepatan Pemberian Antibiotik Berdasarkan Alur Gyssens dengan Perbaikan Klinis Pasien pada Pneumonia Komunitas

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