Upregulated pneumococcal adhesion molecule (platelet-activating factor receptor) may predispose COPD patients to community-acquired pneumonia

Shukla, Shakti D.; Hansbro, Philip M.; Walters, E. Haydn

doi:10.2147/copd.s151142

Cited by 4 publications

(1 citation statement)

References 6 publications

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“…Elevated HIF-1α upregulates platelet-activating factor receptor (PAFR) expression [ 77 ], and as a major adhesion receptor for respiratory bacteria, PAFR can promote airway inflammation and vascular endothelial cell injury when upregulated [ 78 ]. Therefore, clinical studies should pay attention to PAFR indicators in COPD patients, which may be a red flag for recalcitrant bacterial infections or a predisposition to pneumonia [ 79 ].…”

Section: Hypoxia-mediated Cellular Senescence and Inflammatory Respon...mentioning

confidence: 99%

Hypoxia in Aging and Aging-Related Diseases: Mechanism and Therapeutic Strategies

Wei

Giunta²,

Xia

2022

IJMS

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As the global aging process continues to lengthen, aging-related diseases (e.g., chronic obstructive pulmonary disease (COPD), heart failure) continue to plague the elderly population. Aging is a complex biological process involving multiple tissues and organs and is involved in the development and progression of multiple aging-related diseases. At the same time, some of these aging-related diseases are often accompanied by hypoxia, chronic inflammation, oxidative stress, and the increased secretion of the senescence-associated secretory phenotype (SASP). Hypoxia seems to play an important role in the process of inflammation and aging, but is often neglected in advanced clinical research studies. Therefore, we have attempted to elucidate the role played by different degrees and types of hypoxia in aging and aging-related diseases and their possible pathways, and propose rational treatment options based on such mechanisms for reference.

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Section: Hypoxia-mediated Cellular Senescence and Inflammatory Respon...mentioning

confidence: 99%

Hypoxia in Aging and Aging-Related Diseases: Mechanism and Therapeutic Strategies

Wei

Giunta²,

Xia

2022

IJMS

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Cancer antigen-125 levels correlate with pleural effusions and COPD-related complications in people living at high altitude

Li¹,

Ma²,

Gan

et al. 2018

Medicine

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Childhood infections, asthma and allergy trajectories, and chronic rhinosinusitis in middle age: A prospective cohort study across six decades

Perret,

Idrose,

Walters

et al. 2024

Allergy

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IntroductionEvidence on the early life risk factors of adult CRS, and the history of asthma and allergies across the life course, is limited.AimTo investigate relationships between respiratory infective/allergic conditions in childhood, and asthma and allergies across the life course and CRS in middle age.MethodsData were from the population‐based Tasmanian Longitudinal Health Study (TAHS) cohort, first studied in 1968 when aged 6–7 years (n = 8583) and serially followed into middle age (n = 3609). Using a well‐accepted epidemiological definition, participants were assigned a CRS‐severity subtype at age 53: no sinusitis/CRS (reference); past doctor diagnosis only; current symptoms without doctor diagnosis; and doctor‐diagnosed CRS with current symptoms. Relationships with infective/allergic respiratory illnesses at age 7, and previously published asthma‐allergy trajectories from 7 to 53 years, were examined using multinominal regression.ResultsIn middle age, 5.8% reported current CRS symptoms with 2.5% doctor‐diagnosed. Childhood conditions associated with symptomatic doctor‐diagnosed CRS included frequent head colds (multinomial odds ratio [mOR] = 2.04 (95% confidence interval [95% CI]: 1.24, 3.37)), frequent tonsillitis (mOR = 1.61 [95% CI: 1.00, 2.59]) and current childhood asthma (mOR = 2.23 [95% CI: 1.25, 3.98]). Life course trajectories that featured late‐onset or persistent asthma and allergies were associated with all CRS subtypes in middle age; early‐onset persistent asthma and allergies (mOR = 6.74, 95% CI: 2.76, 16.4); late‐onset asthma allergies (mOR = 15.9, 95% CI: 8.06, 31.4), and late‐onset hayfever (mOR = 3.02, 95% CI: 1.51, 6.06) were associated with symptomatic doctor‐diagnosed CRS.ConclusionCurrent asthma, frequent head colds and tonsillitis at age 7 could signal a susceptible child who is at higher risk for CRS in mid‐adult life and who might benefit from closer monitoring and/or proactive management. Concurrent asthma and allergies were strongly associated and are potential treatable traits of adult CRS.

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Upregulated pneumococcal adhesion molecule (platelet-activating factor receptor) may predispose COPD patients to community-acquired pneumonia

Cited by 4 publications

References 6 publications

Hypoxia in Aging and Aging-Related Diseases: Mechanism and Therapeutic Strategies

Hypoxia in Aging and Aging-Related Diseases: Mechanism and Therapeutic Strategies

Cancer antigen-125 levels correlate with pleural effusions and COPD-related complications in people living at high altitude

Childhood infections, asthma and allergy trajectories, and chronic rhinosinusitis in middle age: A prospective cohort study across six decades

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