Risk of Acute Lymphoblastic Leukemia: Results of a Case-Control Study

Rafieemehr, Hassan; Calhor, Fereshteh; Esfahani, Hossein Nasr; Gholiabad, Somayeh Ghorbani

doi:10.31557/apjcp.2019.20.8.2477

Cited by 19 publications

(23 citation statements)

References 34 publications

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“…The details of included studies for the subsequent subgroup analysis are shown in Additional file 1: Table S3. Moreover, after excluding studies with the breastfeeding only as dichotomous variable, and no sufficient data of the number of cases and controls in each breastfeeding category, 23 studies were included for leukemia [ 13 , 14 , 18 , 34 – 36 , 38 – 43 , 46 , 47 , 54 , 56 , 58 , 61 , 63 , 64 , 70 – 72 ], 6 studies for lymphoma [ 14 , 33 , 36 , 40 , 43 , 46 ], and 6 studies for brain tumors [ 14 , 40 , 44 , 51 , 64 , 67 ] in dose-response meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

“… 5 Serious Lingappa, 2018, India [ 71 ] 2015 HC-CS 120/120 1–15 Kidwai Institute of Oncology the elder sibling of the cases Leukemia ( N = 120) Never/< 4/4–6/6–9/ 9–12/13–18/ 19–24/> 24;Ever vs. never Interview of mothers Matched: parental education, socioeconomic status, and the region of residence.Adjusted: none. 5 Moderate Rafieemehr, 2019, Iran [ 72 ] 2015–2018 HC-CS 125/130 1–12 Be’sat Hospital of Hamadan University of Medical Sciences Hospital (healthy subjects) ALL ( N = 125) Ever vs. never; 1–3/4–6/7–9/ 10–12/≥ 24 Interview of parents Matched: age, sex, gender, and residence location.Adjusted: none. 6 Serious Bauer, 2020, France [ 73 ] 2015–2018 PC-CS 112/996 0.5–11 ESTELLE, 2010–2011 Population Wilms tumor ( N = 112) Never/ < 3/3–5/≥ 6; Ever vs. never Telephone interview of mothers Matched: age and gender.…”

Section: Resultsmentioning

confidence: 99%

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Breastfeeding and the risk of childhood cancer: a systematic review and dose-response meta-analysis

Sun

Zhu

et al. 2021

BMC Med

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Background The aim of this study was to quantitatively summarize the available evidence on the association of breastfeeding with the risk of childhood cancer. Methods A literature search of PubMed and Embase databases was performed to identify eligible observational studies published from inception to July 17, 2020. The categorical and dose-response meta-analysis was conducted by pooling relative risk (RR) or odds ratio (OR) estimates with 95% confidence intervals (CIs). Potential sources of heterogeneity were detected by meta-regression and stratification analysis. Sensitivity analysis and publication bias test were also carried out. Results Forty-five articles involving 475,579 individuals were included in the meta-analysis. Among the thirty-three studies on the association between breastfeeding and risk of childhood leukemia, the pooled risk estimates were 0.77 (95% CI, 0.65–0.91) and 0.77 (95% CI 0.63–0.94) for ever versus non/occasional breastfeeding and longest versus shortest breastfeeding duration group, respectively. There was clear indication for non-linear dose-response relationship between breastfeeding duration and the risk of childhood leukemia (P non-linear < 0.001). The most protective effect (OR, 0.66, 95% CI 0.62–0.70) was observed at a breastfeeding duration of 9.6 months. Four studies examined, the association between breastfeeding and risk of childhood neuroblastoma, and significant inverse associations were consistently observed in both the comparisons of ever breastfeeding versus non/occasional breastfeeding (OR = 0.59, 95% CI 0.44–0.81) and longest versus shortest breastfeeding (OR = 0.61, 95% CI 0.44–0.83). However, no associations of breastfeeding with risk of other cancers were found. Conclusions Our study supports a protective role of breastfeeding on the risk of childhood leukemia, also suggesting a non-linear dose-response relationship. Further studies are warranted to confirm the association between breastfeeding and risk of childhood neuroblastoma.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Breastfeeding and the risk of childhood cancer: a systematic review and dose-response meta-analysis

Sun

Zhu

et al. 2021

BMC Med

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“…En Irán, en 125 menores de hasta 15 años con LLA pareados con 130 niños por la edad, género y localidad de residencia, los autores encontraron que los menores con padres que no tenían un elevado nivel educativo, tuvieron un riesgo (OR) de 2,67, IC 95% (1,45) comparado con los menores con padres que tenían un alto nivel educativo 40 . En China, los investigadores encontraron un riesgo elevado entre los que no tenían o tenían un bajo nivel educativo 20 .…”

Section: Discussionunclassified

“…En esta investigación, también se evaluó el género y la edad de los menores de 14 años, la edad de la madre y el antecedente de evento traumático, ninguno de ellos, se asoció a LLA. Otros investigadores, tampoco han encontrado asociación entre el género de los niños o adolescentes y el riesgo de padecer LLA 38,40 . Se ha identificado que el pico de la incidencia de la LLA está entre los 2 y 5 años 42 .…”

Section: Discussionunclassified

“…una de las limitaciones de este estudio es no haber calculado el tamaño de muestra para identificar el riesgo esperado; sin embargo, se han publicado estudios de cohorte con tamaños de muestra similares al presente estudio 38,40 ; sin embargo, la identificación de la LME como factor protector es consistente con los hallazgos previos 13,17,20 y el hallazgo del nivel educativo también es consistente con un estudio previo 38 . En futuros estudios debe evaluarse si el tener secundaria completa es una variable de confusión.…”

Section: Discussionunclassified

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Lactancia materna exclusiva como factor protector de la leucemia linfoblástica aguda

Saravia-Bartra

Cazorla²,

Ignacio-Cconchoy

et al. 2021

Andes pediatr

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La leucemia linfoblástica aguda representa más del 30% de todos los tipos de cáncer en niños entre 0 y 9 años a nivel global. En el Perú, no se ha evaluado si la lactancia materna exclusiva es un factor protector para la leucemia linfoblástica.Objetivo: Identificar los factores protectores y de riesgo asociados a la leucemia linfoblástica aguda en niños y adolescentes entre 0 y 13 años en un hospital nacional, Lima, Perú.Pacientes y Método: Estudio observacional, analítico, diseño caso-control. Se evaluaron 112 casos con diagnóstico de leucemia linfoblástica y 229 controles. Los datos fueron recogidos por entrevistas a las madres de ambos grupos. Se estimó la magnitud de la asociación entre la leucemia y la lactancia exclusiva mediante el odds ratio (OR) y regresión logística multivariado en Stata v 12.Resultados: El 50,9% (57/112) de los casos y el 51,5% (118/229) de los controles fueron del género masculino. La media de edad entre los casos fue 6,7 ± 3,2 años y entre los controles 5,7 ± 3,5 años. La media de edad de la madre entre los casos fue 35,9 ± 6,5 y entre los controles fue 34,1 ± 7,1 años. La lactancia materna exclusiva se asocia a menor riesgo de leucemia en un 44% respecto a aquellos que no tuvieron, OR 0,56, p = 0,017, IC 95% (0,35-0,90). La educación secundaria completa se asocia a menor riesgo de leucemia en un 62%, OR 0,38 IC 95% (0,15-0,61).Conclusiones: La lactancia materna exclusiva y la educación secundaria completa de la madre son factores asociados a menor riesgo de leucemia linfoblástica aguda en niños y en adolescentes.

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Association of cesarean section with risk of childhood leukemia: A meta‐analysis from an observational study

Yang¹,

et al. 2022

Hematological Oncology

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Recent studies suggest that children born via cesarean section (CS) are predisposed to immune‐mediated diseases later in life. The association between CS and childhood leukemia was investigated in this meta‐analysis of observational studies. Two researchers independently searched PubMed, Web of Science, Embase, and Cochrane Library for literature on the association between CS and childhood leukemia before February 2022. And pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated to determine the link between CS and childhood leukemia. The preliminary search resulted in 1321 articles and 16 articles were finally included after screening. The primary outcome was the risk of leukemia in children born via CS versus those born vaginally. The results revealed that having a CS was associated with an increased risk of childhood leukemia compared to having vaginal section (VS) (OR = 1.07, 95% CI: 1.02–1.13, p = 0.01), especially for acute lymphoblastic leukemia (ALL) (OR = 1.09, 95% CI: 1.03–1.16, p = 0.004). Children delivered via elective CS had a higher risk of ALL (OR = 1.18, 95% CI: 1.07–1.31, p = 0.001), but emergency CS did not. It is worth noting that neither emergency CS nor elective CS were found to be associated with acute myeloid leukemia. Compared to VS, CS increased the risk of leukemia in children, with elective CS significantly increasing ALL risk.

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Risk of Acute Lymphoblastic Leukemia: Results of a Case-Control Study

Cited by 19 publications

References 34 publications

Breastfeeding and the risk of childhood cancer: a systematic review and dose-response meta-analysis

Breastfeeding and the risk of childhood cancer: a systematic review and dose-response meta-analysis

Lactancia materna exclusiva como factor protector de la leucemia linfoblástica aguda

Association of cesarean section with risk of childhood leukemia: A meta‐analysis from an observational study

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