Breastfeeding and the risk of childhood cancer: a systematic review and dose-response meta-analysis

Su, Qing; Sun, Xiaohui; Zhu, Liwen; Yan, Qin; Zheng, Pei-Wen; Mao, Yingying; Ye, Ding

doi:10.1186/s12916-021-01950-5

Cited by 35 publications

(36 citation statements)

References 90 publications

(51 reference statements)

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“…This international pooled analysis found that breastfeeding ≥4 months was associated with reduced odds of childhood ALL. Previous meta‐ and pooled analyses suggest a modest protective effect of breastfeeding ≥6 months for ALL 15,16,18,21,32 . Many breastfed children are weaned before 6 months of age, and few studies have evaluated associations with shorter breastfeeding durations.…”

Section: Discussionmentioning

confidence: 99%

Infant feeding practices and childhood acute leukemia: Findings from the Childhood Cancer & Leukemia International Consortium

Schraw

Bailey

Bonaventure

et al. 2022

Intl Journal of Cancer

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Increasing evidence suggests that breastfeeding may protect from childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). However, most studies have limited their analyses to any breastfeeding, and only a few data have examined exclusive breastfeeding, or other exposures such as formula milk. We performed pooled analyses and individual participant data metaanalyses of data from 16 studies (N = 17 189 controls; N = 10 782 ALL and N = 1690 AML cases) from the Childhood Leukemia International Consortium (CLIC) to characterize the associations of breastfeeding duration with ALL and AML, as well as exclusive breastfeeding duration and age at introduction to formula with ALL. In unconditional multivariable logistic regression analyses of pooled data, we observed decreased odds of ALL among children breastfed 4 to 6 months (0.88, 95% CI 0.81‐0.96) or 7 to 12 months (OR 0.85, 0.79‐0.92). We observed a similar inverse association between breastfeeding ≥4 months and AML (0.82, 95% CI 0.71‐0.95). Odds of ALL were reduced among children exclusively breastfed 4 to 6 months (OR 0.73, 95% CI 0.63‐0.85) or 7 to 12 months (OR 0.70, 95% CI 0.53‐0.92). Random effects metaanalyses produced similar estimates, and findings were unchanged in sensitivity analyses adjusted for race/ethnicity or mode of delivery, restricted to children diagnosed ≥1 year of age or diagnosed with B‐ALL. Our pooled analyses indicate that longer breastfeeding is associated with decreased odds of ALL and AML. Few risk factors for ALL and AML have been described, therefore our findings highlight the need to promote breastfeeding for leukemia prevention.

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Section: Discussionmentioning

confidence: 99%

Infant feeding practices and childhood acute leukemia: Findings from the Childhood Cancer & Leukemia International Consortium

Schraw

Bailey

Bonaventure

et al. 2022

Intl Journal of Cancer

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“…Strong evidence supports breastfeeding as a protective factor against pediatric B-cell ALL 10,13 . In the present study, we found that the absence of breastfeeding in our population was associated with an increased risk of further development of B-cell ALL.…”

Section: Discussionmentioning

confidence: 99%

“…In a meta-analysis, Su et al found that breastfeeding for 6 months and 12 months reduced the risk of childhood leukemia by 20% and 27%, respectively. They observed this protective effect in populations from Asia but not Europe, North America, or Oceania 10 . In Mexico, according to the 2019 National Health and Nutrition Survey (ENSANUT, in Spanish), about half of the children < 2 years have continuous breastfeeding in the 1 st year of life (12-15 months), and a third in the 2 nd year of life (20-23 months) 11 .…”

Section: Introductionmentioning

confidence: 94%

Breastfeeding and acute lymphoblastic leukemia in a middle-income country: a Mexican perspective

Mancı́as-Guerra¹,

Nuño-Vázquez²,

Gutiérrez-Aguirre³

et al. 2023

RMU

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Objective. It has been reported that breastfeeding for 6 and 12 months reduced 20% and 27% of the risk of childhood leukemia, respectively. We present the results of a case-control study about breastfeeding and B-cell acute lymphoblastic leukemia (B-cell ALL) risk in a Mexican pediatric population. Patients and methods. We conducted a case-control study, and a 20-question survey was applied to the patient's parents. A patient was considered to have been nursed if they received at least 1 month of breastfeeding. For the control group, patients who attended our hospital's Healthy Child Care Clinic were consecutively selected. Results. The absence of breastfeeding was associated with an odds ratios (OR) of 2.7 for the further development of B-cell ALL. For the subsequent presence of malignancy, the group with 0-1 month of lactation showed an OR of 3.1 compared to the group with more than 6 months of breastfeeding. Conclusions. In the present study, the absence of breastfeeding in our population was associated with an increased risk for the further development of B-cell ALL. Furthermore, it was found that a lower risk for later development of B-cell ALL in their offspring was associated with a lower maternal age.

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“…Breastfeeding decreases the risk of several illnesses for both mother and child, including maternal breast and ovarian cancers, and child allergies, asthma, and gastric issues (for an overview, see Davis et al, 2021 ; Dieterich et al, 2013 ). A recent meta – analysis conducted by Su et al (2021) demonstrated a 23% reduction in the likelihood of childhood leukaemia when an infant was breastfed or occasionally breastfed versus being formula fed, and a 23% decreased risk between the longest and shortest breastfeeding durations. It is clear based on evidence that there is a significant need to improve breastfeeding rates in the United Kingdom.…”

Section: Discussionmentioning

confidence: 99%

Birth Experiences, Breastfeeding, and the Mother-Child Relationship: Evidence from a Large Sample of Mothers

Davis

Sclafani

2022

Can J Nurs Res

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Background It is a priority for public health professionals to improve global breastfeeding rates, which have remained low in Western countries for more than a decade. Few researchers have addressed how maternal perceptions of birth experiences affect infant feeding methods. Furthermore, mixed results have been shown in research regarding breastfeeding and mother-child bonding, and many studies are limited by small sample sizes, representing a need for further investigation. Purpose We aimed to examine the relationship between subjective birth experiences and breastfeeding outcomes, and explored whether breastfeeding affected mother-infant bonding. Methods 3,080 mothers up to three years postpartum completed a cross – sectional survey. Results Mothers who had more positive birth experiences were more likely to report breastfeeding their babies. Moreover, mothers who perceived their birth as more positive were more likely to breastfeed their child for a longer period (over 9 months) than those who had more negative experiences. In line with recent research, breastfeeding behaviours were not associated with reported mother-infant bonding. Conclusions Mothers who reported better birth experiences were most likely to breastfeed, and breastfeed for longer. We find no evidence to suggest that feeding methods are associated with bonding outcomes.

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Breastfeeding and the risk of childhood cancer: a systematic review and dose-response meta-analysis

Cited by 35 publications

References 90 publications

Infant feeding practices and childhood acute leukemia: Findings from the Childhood Cancer & Leukemia International Consortium

Infant feeding practices and childhood acute leukemia: Findings from the Childhood Cancer & Leukemia International Consortium

Breastfeeding and acute lymphoblastic leukemia in a middle-income country: a Mexican perspective

Birth Experiences, Breastfeeding, and the Mother-Child Relationship: Evidence from a Large Sample of Mothers

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