Risk factors for the progression of chronic kidney disease after acute kidney
            injury

Pereira, Benedito; BARRETO, S. A. F.; Gentil, Thais Marques Sanches; Assis, Larissa S; Soeiro, Emília M.D.; Castro, Isac de; Laranja, Sandra Maria Rodrigues

doi:10.5935/0101-2800.20170041

Cited by 22 publications

(14 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the current study, the incidence of AKI in patients with septic shock was 38% on admission, which is consistent with previous studies reporting an incidence of approximately 35% [17]. AKI can accelerate the progression of CKD [7,18,19], but little is known about the association between AKI severity and the development of CKD. Ishani et al showed that CKD developed in 6.6%–10.5% of elderly patients with AKI [8].…”

Section: Discussionsupporting

confidence: 90%

One-Year Progression and Risk Factors for the Development of Chronic Kidney Disease in Septic Shock Patients with Acute Kidney Injury: A Single-Centre Retrospective Cohort Study

Kim

Ryoo

et al. 2018

JCM

View full text Add to dashboard Cite

(1) Background: Sepsis-associated acute kidney injury (AKI) can lead to permanent kidney damage, although the long-term prognosis in patients with septic shock remains unclear. This study aimed to identify risk factors for the development of chronic kidney disease (CKD) in septic shock patients with AKI. (2) Methods: A single-site, retrospective cohort study was conducted using a registry of adult septic shock patients. Data from patients who had developed AKI between January 2011 and April 2017 were extracted, and 1-year follow-up data were analysed to identify patients who developed CKD. (3) Results: Among 2208 patients with septic shock, 839 (38%) had AKI on admission (stage 1: 163 (19%), stage 2: 339 (40%), stage 3: 337 (40%)). After one year, kidney function had recovered in 27% of patients, and 6% had progressed to CKD. In patients with stage 1 AKI, 10% developed CKD, and mortality was 13% at one year; in patients with stage 2 and 3 AKI, the CKD rate was 6%, and the mortality rate was 42% and 47%, respectively. Old age, female, diabetes, low haemoglobin levels and a high creatinine level at discharge were seen to be risk factors for the development of CKD. (4) Conclusions: AKI severity correlated with mortality, but it did not correlate with the development of CKD, and patients progressed to CKD, even when initial AKI stage was not severe. Physicians should focus on the recovery of renal function, and ensure the careful follow-up of patients with risk factors for the development of CKD.

show abstract

Section: Discussionsupporting

confidence: 90%

One-Year Progression and Risk Factors for the Development of Chronic Kidney Disease in Septic Shock Patients with Acute Kidney Injury: A Single-Centre Retrospective Cohort Study

Kim

Ryoo

et al. 2018

JCM

View full text Add to dashboard Cite

show abstract

“…Acute kidney injury has been found to damage adhesion endothelium and cause maladaptive repair of kidney cells [21]. Pereira BJ et al [22] found that patients who had had acute kidney injuries had decreased glomerular filtration rates at follow up. Previously, we also reported that patients who had had an SH event also had decreased glomerular filtration rates at 8-months follow-up, the most vulnerable patients being those with higher baseline blood creatinine values [23].…”

Section: Discussionmentioning

confidence: 99%

Severe Hypoglycemia as a Predictor of End-Stage Renal Disease in Type 2 Diabetes: A National Cohort Study

Lee

Yen

Shin

et al. 2019

IJERPH

View full text Add to dashboard Cite

Aims: This study investigated whether there is a link between severe hypoglycemia and progression into end-stage renal disease (ESRD) in patients with type 2 diabetes. Methods: Tapping into Taiwan’s Health Insurance Research Database, we identified all type 2 diabetes patients between 1996 and 2013 and identified those diagnosed with a severe hypoglycemia episode during an emergency department visit and those who were not. Controls were then matched 1:1 for age, sex, index year, and medication. Results: We identified 468,421 type 2 diabetes patients diagnosed as having severe hypoglycemia in an emergency department visit. Compared with controls, these patients with SH had a higher risk of all-cause mortality (Hazard Ratio (HR), 1.76; 95% confidence interval, 1.61–1.94) and progressed into ESRD within a shorter period of time. Results were similar after controlling for competing risk. Conclusion: Severe hypoglycemia is significantly associated with worsening renal dysfunction in patients with type 2 diabetes and hastened progression into ESRD.

show abstract

“…When comparing the data collected in the ICUad, there was no difference between the groups for serum creatinine (survivors: 1.1 [0.7-1.7] mg/dL vs. nonsurvivors: 1.1 [0.8-1.6] mg/dL; p-value 0.547), but oliguria upon admission was more frequent among non-survivors (n= 25; 10.3% vs. survivors group: n= 11; 3.0%; p-value <0.001). Similarly, APACHE II score was also significantly higher among those who died (median 28 [23][24][25][26][27][28][29][30][31] Non-survivors had less need for NSAIDs (n= 98, 40.3% vs. survivor group: n= 216, 58.4%, p-value <0.001), but higher fluid balance alterations and higher frequency of organ dysfunction ( Table 2).…”

Section: Resultsmentioning

confidence: 99%

“…22 Sepsis is the main AKI cause, 5 substantially increases the risk of death in the critically ill patients, both in adult and pediatric populations, 23 and contributes to the progression of chronic kidney disease after AKI. 24 We did not include sepsis occurrence and sepsis-associated AKI in the multivariate models of mortality due to multicollinearity.…”

Section: Discussionmentioning

confidence: 99%

Non-recovery of renal function is a strong independent risk factor associated with mortality in AKI patients

et al. 2020

View full text Add to dashboard Cite

Introduction: Acute kidney injury (AKI) is a recurrent complication in the intensive care unit (ICU) and is associated with negative outcomes. Objective: To investigate factors associated with mortality in critically ill AKI patients in a South Brazilian ICU. Methods: The study was observational retrospective involving AKI patients admitted to the ICU between January 2011 and December 2016 of at least 18 years old upon admission and who remained in the ICU at least 48 hours. Comparisons between selected characteristics of survivor and non-survivor groups were done using univariate analysis; multivariate logistic regression was applied to determine factors associated with patient mortality. Results: Of 838 eligible patients, 613 participated in the study. Men represented the majority (61.2%) of the patients, the median age was 53 years, and the global mortality rate was 39.6% (n= 243). Non-recovery of renal function after AKI (OR= 92.7 [38.43 - 223.62]; p <0.001), major surgery-associated AKI diagnosis (OR= 16.22 [3.49 - 75.38]; p <0.001), and the use of vasoactive drugs during the ICU stay (OR = 11.49 [2.46 - 53.70]; p <0.002) were the main factors independently associated with patient mortality. Conclusion: The mortality rate observed in this study was similar to that verified in other centers. Non-recovery of renal function was the variable most strongly associated with patient mortality, suggesting that the prevention of factors that aggravate or maintain the AKI episode should be actively identified and mitigated, possibly constituting an important strategy to reduce mortality in AKI patients.

show abstract

Risk factors for the progression of chronic kidney disease after acute kidney injury

Abstract: Being an elderly male patient with AKI due to sepsis and obstruction was correlated with progression to CKD following discharge.

Cited by 22 publications

References 0 publications

One-Year Progression and Risk Factors for the Development of Chronic Kidney Disease in Septic Shock Patients with Acute Kidney Injury: A Single-Centre Retrospective Cohort Study

One-Year Progression and Risk Factors for the Development of Chronic Kidney Disease in Septic Shock Patients with Acute Kidney Injury: A Single-Centre Retrospective Cohort Study

Severe Hypoglycemia as a Predictor of End-Stage Renal Disease in Type 2 Diabetes: A National Cohort Study

Non-recovery of renal function is a strong independent risk factor associated with mortality in AKI patients

Contact Info

Product

Resources

About