Risk factors for recurrent ectopic pregnancy: a case–control study

Zhang, D; Shi, Wenjing; C, Li; Jj, Yuan; Xia, Wei; Rh, Xue; Sun, Jun; Zhang, J

doi:10.1111/1471-0528.14011

Cited by 30 publications

(30 citation statements)

References 28 publications

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“…The results of this study showed that comparing with salpingectomy, the risk of REP after a conservative operation was increased. Some previous reports are consistent with our findings (21,22). In addition, our data also showed that there was no correlation between REP and the number of previous EPs.…”

Section: Previous History Of Ep and Repsupporting

confidence: 93%

Risk Factors of Recurrent Ectopic Pregnancy in Patients Treated With in vitro Fertilization Cycles: A Matched Case-Control Study

Shi

et al. 2020

Front. Endocrinol.

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Objective: To study the risk factors for recurrent ectopic pregnancy (REP) in patients undergoing in vitro fertilization (IVF). Methods: This was a 1:4 matched case-control study that enrolled 227 REP patients and 908 matched intrauterine pregnancy (IUP) patients from the assisted reproductive technology (ART) center of the First Affiliated Hospital of Zhengzhou University from January 2012 to November 2019. Univariate analysis was carried out between the two groups for the occurrence of REP. Multivariate logistic regression analysis was used to explore the risk factors of REP after IVF. Results: The results of univariate analysis showed that there were significant differences in previous treatment of EP, stage of embryo and the number of embryos transferred between the two groups (all P < 0.05). The other factors did not have a significant effect on the probability of developing REP. Multivariate logistic regression analysis showed that after adjusting for confounders, previous treatment of EP, type of embryos transferred and stage of embryo were related to the occurrence of REP (all P < 0.05). Conclusion: Conservative treatment, frozen-thawed embryo transfer and cleavage embryo transfer were independent risk factors for REP after ART treatment.

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Section: Previous History Of Ep and Repsupporting

confidence: 93%

Risk Factors of Recurrent Ectopic Pregnancy in Patients Treated With in vitro Fertilization Cycles: A Matched Case-Control Study

Shi

et al. 2020

Front. Endocrinol.

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“…[3] The general occurrence of EP redoubled during the 20 th century, greatly linked with an augmented occurrence of pelvic inflammatory disease, artificial reproductive technologies, and increased maternal age to name a few. [4,5] The fatality of an EP multiplies with the chance of an impending rupture. It can detonate a potentially life-threatening intra-abdominal hemorrhage and impair future fertility.…”

Section: Introductionmentioning

confidence: 99%

Serum soluble FMS-like tyrosine kinase-1 in ectopic pregnancy

et al. 2019

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CONTEXT: The diagnosis of an ectopic pregnancy (EP) requires the usage of serial beta-human chorionic gonadotropin (hCG) measurements and ultrasonography to locate the gestational sac. With the rising trends in its incidence, a rapid, noninvasive biomarker to detect this condition at the earliest can aid in decreasing the morbidity and mortality linked with EP. AIMS: This study was performed to determine the serum level of soluble FMS-like tyrosine kinase-1 (sFLT-1) at 4–10-week gestation in EP and normal pregnancy and to identify whether it can be used as a biomarker to distinguish an EP from a normal intrauterine pregnancy. SETTINGS AND DESIGN: This was a prospective case–control study conducted over 2 years from 2015 to 2017 in 280 women between the age groups of 19 and 38 years at a tertiary level hospital. SUBJECTS AND METHODS: Levels of sFLT-1 in sera of 140 women with EP and 140 women with normal pregnancy were assayed by a sandwich enzyme-linked immunosorbent assay at Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India. STATISTICAL ANALYSIS USED: Statistical analyses were performed with SPSS software version 16.0, and P ≤ 0.05 was considered statistically significant. RESULTS: The median sFLT-1 level in EP was 419 pg/ml. This was significantly lower than the value of 898 pg/ml in normal pregnancy. Receiver operating characteristic curve analysis showed that at a cutoff of 623 pg/ml, sFLT-1 was able to distinguish an EP from a normal intrauterine pregnancy with a sensitivity of 98.6% and a specificity of 90.7%. CONCLUSIONS: The present study showed the significant early lowering of sFLT-1 in EP and may be considered as an effective biomarker compared to beta-hCG.

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“…Women with depression were significantly older than controls so that age may be a possible cofactor. One study has shown that the risk of spontaneous abortion increases from 8.7% at the age of 22 to 84.1% at the age of 48 years 17 , 22 , 23 .…”

Section: Discussionmentioning

confidence: 99%

“…Als möglicher Kofaktor ist zu berücksichtigen, dass die Frauen der Gruppe mit Depression signifikant älter waren als die Frauen der Kontrollgruppe. In einer Studie konnte bereits beschrieben werden, dass das Risiko für einen Spontanabort von 8,7% im Alter von 22 Jahren auf 84,1% im Alter von 48 Jahren ansteigt 17 , 22 , 23 .…”

Section: Diskussionunclassified

Pregnancy Outcomes in Maternal Neuropsychiatric Illness and Substance Abuse

Bartel

Costa

Kropf

et al. 2017

Geburtshilfe Frauenheilkd

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Introduction Worldwide the prevalence of neuropsychiatric illness among women of reproductive age is higher than ever before. This study investigates the influences of maternal substance abuse/dependence and neuropsychiatric illness on pregnancy and neonatal outcomes. Patients and Methods Using a retrospective study design 185 pregnancies in women with neuropsychiatric illnesses or substance abuse were identified at a single centre over a period of 3.25 years and compared to 4907 pregnancies in healthy women without mental illness. Differences in pre-, peri- and postnatal pregnancy parameters were studied. Results Numbers of previous abortions on obstetric history were significantly higher in cases compared to controls, women with depression being especially affected. The number of antenatal visits was also higher among cases, especially in women with depression. The caesarean section rate was significantly higher in cases compared to controls. Children of women with neuropsychiatric illness were born at lower gestational ages than those of healthy control mothers, however there were no significant differences between case and control groups for birth weight, head circumference or Apgar scores. Some isolated differences were found for disease-specific case subgroups compared to controls. Conclusion The study shows a relationship between maternal neuropsychiatric illness and pregnancy outcomes independent of medication use. Rates of spontaneous abortion were higher. Children were born earlier, yet the neonatal outcomes birth weight, head circumference and Apgar score were not worse than children of mentally healthy women.

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Risk factors for recurrent ectopic pregnancy: a case–control study

Cited by 30 publications

References 28 publications

Risk Factors of Recurrent Ectopic Pregnancy in Patients Treated With in vitro Fertilization Cycles: A Matched Case-Control Study

Risk Factors of Recurrent Ectopic Pregnancy in Patients Treated With in vitro Fertilization Cycles: A Matched Case-Control Study

Serum soluble FMS-like tyrosine kinase-1 in ectopic pregnancy

Pregnancy Outcomes in Maternal Neuropsychiatric Illness and Substance Abuse

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