Risk Factors of Recurrent Ectopic Pregnancy in Patients Treated With in vitro Fertilization Cycles: A Matched Case-Control Study

Yu, Tao; Bu, Zhiqin; Shi, Hao; Song, Hui; Zhang, Yile

doi:10.3389/fendo.2020.552117

Cited by 8 publications

(10 citation statements)

References 28 publications

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“…According to Bozkaya et al, a cut-off value of 0.545 for IOS has 81.6% sensitivity and 59.5% specificity for the prognosis of ectopic pregnancy [144]. This indicator can be especially important during an artificial insemination, as the frequency of ectopic pregnancy and spontaneous abortions in such patients remain high [152].…”

Section: Obstetrics and Gynecologymentioning

confidence: 99%

Ischemia-Modified Albumin: Origins and Clinical Implications

et al. 2021

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Albumin is one of the most abundant proteins in the body of mammals: about 40% of its pool is located in the intravascular space and the remainder is found in the interstitial space. The content of this multifunctional protein in blood is about 60-65% of total plasma proteins. A decrease in its synthesis or changes of functional activity can destabilize oncotic blood pressure, cause a violation of transporting hormones, fatty acids, metals, and drugs. Albumin properties change under ischemic attacks associated with oxidative stress, production of reactive oxygen species, and acidosis. Under these conditions, ischemia-modified albumin (IMA) is generated that has a reduced metal-binding capacity, especially for transition metals, such as copper, nickel, and cobalt. The method of determining the cobalt-binding capability of HSA was initially proposed to evaluate IMA level and then licensed as an ACB test for routine clinical analysis for myocardial ischemia. Subsequent studies have shown the viability of the ACB test in diagnosing other diseases associated with the development of oxidative stress. This review examines recent data on IMA generation mechanisms, describes principles, advantages, and limitations of methods for evaluation of IMA levels, and provides detailed analysis of its use in diagnostic and monitoring therapeutic efficacy in different diseases.

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Section: Obstetrics and Gynecologymentioning

confidence: 99%

Ischemia-Modified Albumin: Origins and Clinical Implications

et al. 2021

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“…Compared with patients with no history of EP, patients with a history of EP had a higher risk of recurrent EP after IVF treatment, which ranged from 0.6% to 8.9% in the published studies [7][8][9]. Previous studies assessing the pregnancy outcomes only focused on women with a previous single EP [7][8][9][10]. There are few data on pregnancy outcomes in women with previous recurrent EP who undergoing IVF treatment [11][12][13][14].…”

Section: Discussionmentioning

confidence: 99%

“…Binary logistic regression was used to identify the odds ratio (OR) and 95% confidence interval (CI) for factors independently related to reproductive outcomes. Variables that are believed to influence both histories of ectopic pregnancy and pregnancy outcome were considered potential confounders [ 5 , 9 , 10 ]. These variables included female age, infertility duration, antral follicle count, cause of infertility, stimulation protocols, duration of stimulation, the number of oocytes retrieved, fertilization rate, stage of embryos transferred, type of embryos transferred, and the number of embryos transferred.…”

Section: Methodsmentioning

confidence: 99%

“…The exact reason why the transferred embryos migrate from the uterine cavity to implant extrauterine remains unclear. The type of embryos transferred [10], the stage of embryos transferred [5,10], and the technique of embryo transfer [20][21][22] are potential causes but there is little evidence to support these. Women who receive stimulated cycles are at higher risk of tubal ectopic pregnancy compared with women who undergo natural cycles [5,23].…”

Section: Plos Onementioning

confidence: 99%

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Pregnancy outcomes following in vitro fertilization treatment in women with previous recurrent ectopic pregnancy

Xue

Zhang

2022

PLoS ONE

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Objectives The aim of this study was to investigate the impact of a history of recurrent ectopic pregnancy (EP) on pregnancy outcomes of subsequent in vitro fertilization (IVF) treatment. Methods A retrospective cohort study involving 457 women with a history of recurrent EP (REP group), 912 women with a history of single EP (SEP group), and 1169 women with a history of intrauterine pregnancy (IUP group) as the control group, was conducted. IVF outcomes were compared for each cohort. Results The incidence of EP in the REP group after IVF treatment was significantly lower than those in the SEP group (2.4% vs. 6.8%, P = 0.011), and similar to those in the IUP group (2.4% vs. 2.1%, P = 0.830). No significant differences were observed in the clinical pregnancy rate, miscarriage rate, and live birth rate among the three groups. There was no statistically significant difference in the recurrent EP rate between the salpingectomy and salpingostomy treatments. Adjusting for maternal and treatment factors did not influence live birth rates for women with previous REP compared with women with previous SEP and those with IUP. The odds of EP were 82.2% lower (OR 0.178, 95% CI 0.042–0.762; P = 0.020) in women who had blastocyst transfer compared with cleavage embryo transfer in the SEP group. The odds of EP were over six times (OR 6.260, 95% CI 1.255–31.220; P = 0.025) in women who underwent double embryo transfer as opposed to single embryo transfer in the IUP group. Conclusion Our results indicate that women with previous recurrent EP have a lower risk of EP after IVF in comparison with women with previous single EP. Previous EP has no significant adverse effect on the main IVF outcomes. The salpingostomy and salpingectomy treatments of EP do not significantly affect the incidence of recurrent EP after IVF.

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“…During ART treatment, fallopian tube factors remain a major risk factor for EP, especially in women with a prior history of fallopian tube surgery [14]. Patients who undergo a conservative operation or tubal microsurgery have a higher incidence of EP after assisted pregnancy [15]. Some researchers also supposed that salpingectomy and tubal infertility were the most important variables affecting the risk of IP [13].…”

Section: Discussionmentioning

confidence: 99%

Association of the Number of Embryos Transferred with Ectopic Pregnancy after Embryo Transfer in Patients with Salpingectomy or Proximal Tubal Occlusion

Wen¹,

Zhang²,

Xia³

et al. 2022

Clin. Exp. Obstet. Gynecol.

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Background: With the prevalence of assisted reproductive technology (ART), the incidence of ectopic pregnancy (EP) is increasing, especially in patients with salpingectomy or proximal tubal occlusion. Methods: A total of 11,609 women who were undergoing ART and had undergone salpingectomy or proximal tubal occlusion, and 5388 women who achieved a clinical pregnancy were included in the study. Statistical analysis was used to determine whether the number of embryos transferred was associated with EP. Results: Both the number of embryos transferred and the day of embryo transfer differed significantly between those with and without EP (p < 0.05), while the number of embryos transferred was associated with interstitial pregnancy (IP) (p < 0.05) in those undergoing frozen-thawed embryo transfer (ET) cycles. Following multivariate modeling, the odds of having an EP in women undergoing frozen-thawed ET cycles increased with the number of embryos transferred (odds ratio [OR] 2.003, 95% confidence interval [95% CI] 1.036-3.876). Conclusions: The embryo transfer number was considered a risk factor for EP in patients undergoing frozen-thawed ET who had undergone salpingectomy or proximal tubal occlusion.

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Risk Factors of Recurrent Ectopic Pregnancy in Patients Treated With in vitro Fertilization Cycles: A Matched Case-Control Study

Cited by 8 publications

References 28 publications

Ischemia-Modified Albumin: Origins and Clinical Implications

Ischemia-Modified Albumin: Origins and Clinical Implications

Pregnancy outcomes following in vitro fertilization treatment in women with previous recurrent ectopic pregnancy

Association of the Number of Embryos Transferred with Ectopic Pregnancy after Embryo Transfer in Patients with Salpingectomy or Proximal Tubal Occlusion

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