Risk Factors For<i>Stenotrophomonas Maltophilia</i>Bacteremia In Oncology Patients: A Case–Control Study

Apisarnthanarak, Anucha; Mayfield, Jennie; Garison, Teresa; McLendon, Patricia; DiPersio, John F.; Fraser, Victoria J.; Polish, Louis B.

doi:10.1086/502197

Cited by 68 publications

(42 citation statements)

References 26 publications

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“…Another interesting data is that more than 80% of infections in immunocompromised patients are attributed to microbiota colonizing the patient him/herself (18) . As mentioned, these findings differ from the results obtained from the assessed patients, in whom the predominant microorganism was a gram-negative bacteria, Stenotrophomonas maltophilia, with peculiar characteristics that enable it to adhere and form biofilm in catheters, resulting in catheter infection (16) . A retrospective study that involved hematological patients in a non-neutropenic phase, aimed at investigating the frequency and microorganisms that caused Hickman catheter-related infections underlines the predominance of gram-negative bacteria (68%) in these clients, among which Stenotrophomonas maltoplilia was the most frequent (20) .…”

Section: As Presented Incontrasting

confidence: 85%

“…In a case-control study that involved 52 patients (16) , the mean period from catheter insertion to the development of bacteremia by S. Maltophilia was 60 days, with 11 days as the shortest and 325 days as the longest in situ dwelling time. It should be highlighted that this was the most frequent microorganism, which could justify catheter dwelling times shorter than 60 days.…”

Section: As Presented Inmentioning

confidence: 99%

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Motivo de retirada do cateter de Hickman em pacientes submetidos ao transplante de células-tronco hematopoéticas

Castanho¹,

Silveira

Braga³

et al. 2011

Acta paul. enferm.

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Objective: To identify rationale for removal of the first Hickman catheter implanted in patients undergoing allogeneic hematopoietic stem cell transplantation, the micro-organisms involved in the occurrence of infection, and the length of time the catheter was in situ. Methods: A cross sectional, retrospective study was conducted. The sample consisted of 57 transplant recipients. To conduct chart review, an instrument was developed containing variables related to patient identification, time of catheter use, reason for withdrawal, and isolated micro-organisms. Results: Among the reasons for catheter removal, frequent infection (49%) was the most common; the Stenotrophomonas maltophilia microorganism (25%) was the most frequently isolated. Conclusions: Due to the high incidence of infectious complications leading to Hickman catheter removal, it is essential to standardize catheter care for the health care team, patients and their caregivers. Keywords: Bone marrow transplantation; Hematopoietic stem cell transplantation; Central venous catheterization; Nursing care RESUMO Objetivo: Identificar os motivos da retirada do primeiro cateter de Hickman implantado em pacientes submetidos ao transplante de células-tronco hematopoéticas alogênico, os micro-organismos envolvidos na ocorrência de infecção e o tempo de permanência do cateter in situ. Métodos: Estudo transversal retrospectivo. A amostra foi constituída por 57 prontuários de pacientes transplantados. Para a obtenção dos dados, elaborou-se um instrumento contendo variáveis relativas à identificação do paciente, tempo de permanência do cateter, motivo de retirada e micro-organismo isolado. Resultados: Dentre os motivos de retirada do cateter, destacou-se como o mais frequente a infecção (49%). O Stenotrophomonas maltophilia (25%) foi o micro-organismo identificado com maior frequência. Conclusões: Diante da elevada incidência de complicações infecciosas que levam à retirada do cateter de Hickman, faz-se necessária uma padronização de cuidados relacionados a esse cateter, tanto para a equipe de saúde como ao paciente e seu cuidador. Descritores: Transplante de medula óssea; Transplante de células-tronco hematopoéticas; Cateterismo venoso central; Cuidados de enfermagem RESUMEN Objetivo: Identificar los motivos del retiro del primer catéter de Hickman implantado en pacientes sometidos al transplante de células-tronco hematopoéticas alogénico, los microorganismos involucrados en la ocurrencia de infección y el tiempo de permanencia del catéter in situ. Métodos: Estudio transversal retrospectivo. La muestra estuvo constituída por 57 historias clínicas de pacientes transplantados. Para la obtención de los datos, se elaboró un instrumento conteniendo variables relativas a la identificación del paciente, tiempo de permanencia del catéter, motivo del retiro y microorganismo aislado. Resultados: Entre los motivos del retiro del catéter, se destacó como el más frecuente la infección (49%). El Stenotrophomonas maltophilia (25%) fue el microorganismo identificado con...

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Section: As Presented Incontrasting

confidence: 85%

Section: As Presented Inmentioning

confidence: 99%

Motivo de retirada do cateter de Hickman em pacientes submetidos ao transplante de células-tronco hematopoéticas

Castanho¹,

Silveira

Braga³

et al. 2011

Acta paul. enferm.

View full text Add to dashboard Cite

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“…Risk factors for S. maltophilia infection include underlying malignancy (44), the presence of indwelling devices (e.g., catheters [44,228]), chronic respiratory disease, immunocompromised host (44), prior use of antibiotics (13,228), and long-term hospitalization or ICU stay (187). Risk factors for S. maltophilia infection-associated mortality include malignancy, severe septic shock, and organ failure (120).…”

Section: Risk Factors and Determining Risk Of Infectionmentioning

confidence: 99%

Stenotrophomonas maltophilia: an Emerging Global Opportunistic Pathogen

2012

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SUMMARY Stenotrophomonas maltophilia is an emerging multidrug-resistant global opportunistic pathogen. The increasing incidence of nosocomial and community-acquired S. maltophilia infections is of particular concern for immunocompromised individuals, as this bacterial pathogen is associated with a significant fatality/case ratio. S. maltophilia is an environmental bacterium found in aqueous habitats, including plant rhizospheres, animals, foods, and water sources. Infections of S. maltophilia can occur in a range of organs and tissues; the organism is commonly found in respiratory tract infections. This review summarizes the current literature and presents S. maltophilia as an organism with various molecular mechanisms used for colonization and infection. S. maltophilia can be recovered from polymicrobial infections, most notably from the respiratory tract of cystic fibrosis patients, as a cocolonizer with Pseudomonas aeruginosa . Recent evidence of cell-cell communication between these pathogens has implications for the development of novel pharmacological therapies. Animal models of S. maltophilia infection have provided useful information about the type of host immune response induced by this opportunistic pathogen. Current and emerging treatments for patients infected with S. maltophilia are discussed.

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“…Stenotrophomonas maltophilia is an environmental microorganism, is isolated from various sources in a hospital setting (15,23,24). Stenotrophomonas maltophilia is naturally resistant to many antibiotics, including broad spectrum antimicrobials such as carbapenems, third and fourth generations of cephalosporins.…”

Section: Discussionmentioning

confidence: 99%

Stenotrophomonas maltophilia Infections in Adults: Primary Bacteremia and Pneumonia

Gözel

Çelik

Elaldı

2015

Jundishapur J Microbiol

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Background: Stenotrophomonas maltophilia is the third most frequent non-fermentative Gram-negative bacilli in nosocomial infections, and usually causes severe infections such as primary bacteremia and pneumonia. Objectives: The current study aimed to compare the demographic and clinical characteristics, microbiological findings and final outcomes of the patients with primary bacteremia and nosocomial pneumonia caused by S. maltophilia. Patients and Methods: The current study retrospectively evaluated patients aged 18 years and above with primary bacteremia and nosocomial pneumonia caused by S. maltophilia from January 2006 to December 2013. Medical records of patients, including reports of clinical microbiology and hospital infection control committee, were evaluated. Results: A total of 71 patients with S. maltophilia nosocomial infections, 35 (49.3%) primary bacteremia and 36 (50.7%) pneumonia, were diagnosed. There were no significant differences in gender, age, and co-morbid diseases, except chronic obstructive pulmonary disease; this infection was significantly higher in patients with pneumonia. A slightly higher 14-day mortality was found in patients with pneumonia, but the difference was not statistically significant. Inappropriate antibiotic use and presence of multiple organ dysfunction syndrome were found as independent risk factors for 14-day mortality in multivariate analysis. Conclusions: A slightly higher mortality in patients with pneumonia, caused by S. maltophilia, was strived to explain by advanced age, higher acute physiology and chronic health evaluation (APACHE II) and sepsis related organ failure assessment (SOFA) score, and also higher inappropriate antibiotic use.

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Risk Factors ForStenotrophomonas MaltophiliaBacteremia In Oncology Patients: A Case–Control Study

Cited by 68 publications

References 26 publications

Motivo de retirada do cateter de Hickman em pacientes submetidos ao transplante de células-tronco hematopoéticas

Motivo de retirada do cateter de Hickman em pacientes submetidos ao transplante de células-tronco hematopoéticas

Stenotrophomonas maltophilia: an Emerging Global Opportunistic Pathogen

Stenotrophomonas maltophilia Infections in Adults: Primary Bacteremia and Pneumonia

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