Risk Factors for Colorectal Cancer in Thailand

Poomphakwaen, Kirati; Promthet, Supannee; Suwanrungruang, Krittika; Kamsa-ard, Siriporn; Wiangnon, Surapon

doi:10.7314/apjcp.2015.16.14.6105

Cited by 7 publications

(8 citation statements)

References 27 publications

(27 reference statements)

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“…A Korean study also reported that former smokers had higher risk of distal cancer in men (HR = 1.4), but not CRC [59]. Nevertheless, there were 2 studies in Thailand and Oman that reported no significant association between smoking and risk of CRC [70,71].…”

Section: Environmental Risk Factorsmentioning

confidence: 99%

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Prevalence and risk factors of colorectal cancer in Asia

et al. 2019

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habits, physical activity, smoking and alcohol consumption. About 25% of the CRC cases have a genetic predisposition, and 5% of CRC patients have inherited factors associated with its development. 5,6 Family history of CRC and the presence of common chronic conditions, such as metabolic syndrome and fatty liver, were among the key factors reported by existing literature. In a report from Continuous Update Project, 7 being physically active, consuming wholegrains, dairy products, foods containing dietary fiber and taking calcium supplements are protective factors against the risk of CRC. 8-11 On the contrary, consuming red or processed meat, consumption of alcoholic beverages, being overweight or obese, and being tall are the risk factors of CRC. 9,11-13 These factors associated with CRC were supported by a meta-analysis including 103 global cohort studies. 14 Recent studies emphasized that global variations in socioeconomic development, dietary habits, lifestyle factors, ethnicity and genetics might be drivers of its diverse epidemiology among different countries. The present review discusses the prevalence of CRC; its risk factors and validated models for risk stratification as developed in various countries.

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Section: Environmental Risk Factorsmentioning

confidence: 99%

“…Drinking alcohol was responsible for higher incidence and mortality of CRC, attributing for 8.7% in men and 1.1% in women in China [68]. Two studies conducted in Thailand [70] and Oman [71] did not show such an association.…”

Section: Environmental Risk Factorsmentioning

confidence: 99%

Prevalence and risk factors of colorectal cancer in Asia

et al. 2019

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“…Liver flukes including Opisthorchis viverrini, Clonorchis sinensis, and schistosomiasis japonica are risk factors for biliary tract cancers. [44][45][46][47] While liver flukes is endemic in Asia, the prevalence in the West is low and hence proportional contribution of liver flukes to biliary tract cancers in the West are unavailable. 47 Therefore, although parasitic infection was not adjusted for in the studies from the West, its influence on the effect estimates is likely to be low.…”

Section: Discussionmentioning

confidence: 99%

Statins associate with lower risk of biliary tract cancers: A systematic review and meta‐analysis

et al. 2022

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Background Biliary tract cancers (BTCs), encompassing cholangiocarcinoma (CCA), gallbladder (GBC), and ampulla of Vater cancers (AVC), are common hepatobiliary cancer after hepatocellular carcinoma with a high mortality rate. As there is no effective chemopreventive agent to prevent BTCs, this study aimed to explore the role of statins on the risk of BTCs. Methods PubMed, Embase, and Cochrane Library from inception until 24 April 2020 were searched according to the Meta‐Analyses of Observational Studies in Epidemiology (MOOSE) guidelines. The adjusted risk ratios (aRRs) of BTCs and individual cancer were pooled using a random‐effects model. Results Eight observational studies (3 cohort and 5 case–control studies) were included with 10,485,231 patients. The median age was 68.0 years (IQR: 67.0–71.5) and 48.3% were male. Statins were associated with a lower risk of all BTCs (aRR: 0.67; 95% CI: 0.51–0.87). The pooled aRR for CCA was 0.60 (95% CI: 0.38–0.94) and GBC was 0.78 (95% CI: 0.68–0.90). There was only one study on AVC with aRR of 0.96 (95% CI: 0.66–1.41). The pooled aRR for lipophilic and hydrophilic statins was 0.78 (95% CI: 0.69–0.88) and 0.70 (95% CI: 0.61–0.80), respectively. The effects were attenuated in studies that adjusted for aspirin and/or non‐steroidal anti‐inflammatory drugs (aRR: 0.80, 95% CI: 0.72–0.89) and metformin (aRR: 0.80, 95% CI: 0.72–0.90). Conclusions Statins, both lipophilic and hydrophobic, were associated with a lower risk of BTCs, particularly CCA and GBC.

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“…One study from Thailand identified risk factors for colorectal cancer in the Thai population. The result showed, no evidence of environmental factors affecting the risk of CRC (Kirati Poomphakwaen et al, 2015). In a study among 2,195 eligible subjects, the results showed that, the prevalence of colorectal adenoma and advanced adenoma was significantly higher in the Helicobacter pylori positive group (25.3 vs. 20.1 %, p=0.004 and 6.1 vs. 2.9 %, p<0.001, respectively) (Hong SN et al, 2012).…”

Section: Introductionmentioning

confidence: 91%

Helicobacter Pylori Associated Gastritis Increases Risk of Colorectal Polyps: a Hospital Based-Cross-Sectional Study in Nakhon Ratchasima Province, Northeastern Thailand

Tongtawee¹,

Kaewpitoon²,

Kaewpitoon³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Background: Colorectal polyps are common in Thailand, particularly in the northeastern region. The present study aimed to determine any correlation between Helicobacter pylori-associated gastritis and colorectal polyps in the Thai population. Materials and Methods: A total of 303 patients undergoing esophagogastroduodenoscopy with colonoscopy for investigation of chronic abdominal pain participated in this study from November 2014 to October 2015. A diagnosis of Helicobacter pylori associated gastritis was made if the bacteria were seen on histopathological examination and a rapid urease test was positive. Colorectal polyps were confirmed by histological examination of colorectal biopsies. Patient demographic data were analyzed for correlations. Results: The prevalence of colorectal polyps was 77 (25.4%), lesions being found more frequently in Helicobacter pylori infected patients than non-infected subjects [38.4% vs. 12.5%; Odds Ratio (OR) (95% CI): 2.26 (1.32 -3.86), p < 0.01]. Patients with Helicobacter pylori -associated gastritis were at high risk of having adenomas featuring dysplasia [OR (95% CI): 1.15 (1.16 -7.99); P = 0.02]. There was no varaition in location of polyps, age group, sex and gastric lesions with respect to Helicobacter pylori status. Conclusions: This study showed that Helicobacter pylori associated gastritis is associated with an increased risk of colorectal polyps, especially adenomas with dysplasia in the Thai population. Patients with Helicobacter pylori-associated gastritis may benefit from concurrent colonoscopy for diagnosis of colorectal polyps as a preventive and early treatment for colorectal cancer.

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Risk Factors for Colorectal Cancer in Thailand

Cited by 7 publications

References 27 publications

Prevalence and risk factors of colorectal cancer in Asia

Prevalence and risk factors of colorectal cancer in Asia

Statins associate with lower risk of biliary tract cancers: A systematic review and meta‐analysis

Helicobacter Pylori Associated Gastritis Increases Risk of Colorectal Polyps: a Hospital Based-Cross-Sectional Study in Nakhon Ratchasima Province, Northeastern Thailand

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