Prevalence and risk factors of colorectal cancer in Asia

Abstract

habits, physical activity, smoking and alcohol consumption. About 25% of the CRC cases have a genetic predisposition, and 5% of CRC patients have inherited factors associated with its development. 5,6 Family history of CRC and the presence of common chronic conditions, such as metabolic syndrome and fatty liver, were among the key factors reported by existing literature. In a report from Continuous Update Project, 7 being physically active, consuming wholegrains, dairy products, foods containing dietary fiber and taking calcium supplements are protective factors against the risk of CRC. 8-11 On the contrary, consuming red or processed meat, consumption of alcoholic beverages, being overweight or obese, and being tall are the risk factors of CRC. 9,11-13 These factors associated with CRC were supported by a meta-analysis including 103 global cohort studies. 14 Recent studies emphasized that global variations in socioeconomic development, dietary habits, lifestyle factors, ethnicity and genetics might be drivers of its diverse epidemiology among different countries. The present review discusses the prevalence of CRC; its risk factors and validated models for risk stratification as developed in various countries.

The relationship between metabolic syndrome and the incidence of colorectal cancer

“…There are some studies [39][40][41] that consider height in the analysis as risk factors for colorectal cancer, and the results of the analysis are also reported to be significant. Based on these similar previous studies, this study considered the relationship between height and colorectal cancer but found no significant correlation.…”

Current challenges in the implementation of precision oncology for the management of metastatic colorectal cancer

“…Colorectal cancer (CRC) is the third most common cancer worldwide, comprising a considerable portion of the disease burden. About half of new cases and deaths occur in Asia, 1 where awareness of CRC has risen in recent times. Approximately 20% of new cases present with distant metastases 2 and 20%-25% of localised cases eventually experience recurrence.…”

Clinical outcomes of submucosal colorectal cancer diagnosed after endoscopic resection: a focus on the need for surgery

“…The incidence of colorectal cancer has been increasing worldwide. 1 Most colorectal cancers originate from precancerous polyps. 2 Therefore, to decrease mortality, it is extremely important to identify precancerous polyps or early colorectal www.irjournal.org cinoma and lymphovascular invasion or tumor budding.…”