Helicobacter Pylori Associated Gastritis Increases Risk of Colorectal Polyps: a Hospital Based-Cross-Sectional Study in Nakhon Ratchasima Province, Northeastern Thailand

Abstract

Background: Colorectal polyps are common in Thailand, particularly in the northeastern region. The present study aimed to determine any correlation between Helicobacter pylori-associated gastritis and colorectal polyps in the Thai population. Materials and Methods: A total of 303 patients undergoing esophagogastroduodenoscopy with colonoscopy for investigation of chronic abdominal pain participated in this study from November 2014 to October 2015. A diagnosis of Helicobacter pylori associated gastritis was made if the bacteria were seen on histopathological examination and a rapid urease test was positive. Colorectal polyps were confirmed by histological examination of colorectal biopsies. Patient demographic data were analyzed for correlations. Results: The prevalence of colorectal polyps was 77 (25.4%), lesions being found more frequently in Helicobacter pylori infected patients than non-infected subjects [38.4% vs. 12.5%; Odds Ratio (OR) (95% CI): 2.26 (1.32 -3.86), p < 0.01]. Patients with Helicobacter pylori -associated gastritis were at high risk of having adenomas featuring dysplasia [OR (95% CI): 1.15 (1.16 -7.99); P = 0.02]. There was no varaition in location of polyps, age group, sex and gastric lesions with respect to Helicobacter pylori status. Conclusions: This study showed that Helicobacter pylori associated gastritis is associated with an increased risk of colorectal polyps, especially adenomas with dysplasia in the Thai population. Patients with Helicobacter pylori-associated gastritis may benefit from concurrent colonoscopy for diagnosis of colorectal polyps as a preventive and early treatment for colorectal cancer.

Toll-Like Receptors are Associated with Helicobacter pylori Infection and Gastric Mucosa Pathology

“…Additionally, approximately 32% of patients with H. pylori-associated gastritis develop gastric ulcers, while only 2% -3% progress to GC (21). With our studies host genetic factors, the Mdm2 SNP309 GG homozygous genotype may be a risk factor for GC in Thai patients (22).…”

Helicobacter pylori infection and increased diabetes prevalence were the risks of colorectal adenoma: a systematic review and meta-analysis

“…[3,6,8,9,19, Nineteen of them are cross-sectional studies [3, 6, 8, 19, 21-24, 25-28, 30, 31, 35, 37-40], and the remaining eight are case-control studies [9, 29, 32-34, 36, 41, 42]. Serology was utilized as the detection method for H. pylori in 14 studies [8, 9, 21, 23, 25-27, 31-35, 38, 39], pathology in 4 [3,22,40,42], UBT in 4 [6,37], CLO in 6 [19,24,30,36], and combining UBT and CLO in 2 [28,29] A flow chart describing the process of study selection is shown in Figure 1. For the meta-analysis, data were extracted from twenty-seven studies with a total of 68,410 patients, and the pooled OR for colorectal adenoma related to H. pylori infection was 1.51 (95% CI 1.39-1.63), although there was significant heterogeneity (p < 0.001) ( Table 1 and Figure 2).…”

Helicobacter pylori infection and increased diabetes prevalence were the risks of colorectal adenoma: a systematic review and meta-analysis

“…[3,6,8,9,19, Nineteen of them are cross-sectional studies [3, 6, 8, 19, 21-24, 25-28, 30, 31, 35, 37-40], and the remaining eight are case-control studies [9, 29, 32-34, 36, 41, 42]. Serology was utilized as the detection method for H. pylori in 14 studies [8, 9, 21, 23, 25-27, 31-35, 38, 39], pathology in 4 [3,22,40,42], UBT in 4 [6,37], CLO in 6 [19,24,30,36], and combining UBT and CLO in 2 [28,29]. A flow chart describing the process of study selection is shown in Figure 1.…”