Risk Factors for Colorectal Cancer

Peterson, Carrie Y.

doi:10.15406/mojs.2015.02.00015

Cited by 5 publications

(5 citation statements)

References 74 publications

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“…Many clinicopathological features of colorectal carcinoma complicating Crohn’s disease or ulcerative colitis are directly comparable and suggest a potential common underlying mechanism. Recent clinical studies have indicated that the increased cancer risk seen in inflammatory bowel disease is probably due to the underlying chronic mucosal inflammation, a high epithelial cell turnover, and an increased rate of sporadic mutations [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

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Tumefactive Crohn's Disease Mimicking Colon Carcinoma in a Young Female: A Case Report

Ansari,

Razzak,

Patibandla

et al. 2024

Cureus

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Tumefactive Crohn’s disease is a rare form of Crohn’s disease that may mimic colon carcinoma macroscopically. This case report describes a 28-year-old female who presented with right-sided abdominal pain and a palpable abdominal mass that had persisted for over a month. Multiple hospitalizations failed to provide an accurate diagnosis until an exploratory laparotomy revealed that the "mass" was the cecum and a perforated ascending colon. A partial right colectomy was performed, sending the specimen for biopsy. The microscopic description showed dense and confluent chronic inflammation in the colonic mucosa and wall, extending to the serosa in some regions. The infiltration comprised lymphocytes and plasma cells, with an admixture of some neutrophils. Aphthous mucosal ulcerations, intramural fissures, and fistulas were present. Immunostains for pan-keratin demonstrated no intramural epithelial elements. The characteristics of this lesion represent tumefactive Crohn’s disease. This case highlights the key microscopic characteristics that pathologists look for when differentiating Crohn's disease from colon carcinoma in a patient presenting with abdominal pain and a colon mass.

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Section: Discussionmentioning

confidence: 99%

“…It has been shown that there are alterations in the inflammatory process that are caused by changes in the innate defense of intestinal mucosa through the expression of adhesion molecules and metalloproteins. Due to this, there is an increased Th1 response leading to the inflammatory cytokines IL-12 and TNF-alpha [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Tumefactive Crohn's Disease Mimicking Colon Carcinoma in a Young Female: A Case Report

Ansari,

Razzak,

Patibandla

et al. 2024

Cureus

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“…CRC is linked to IBD, such as ulcerative colitis or Crohn’s disease. This mechanism is probably due to chronic mucosal inflammation, increased cell turnover, and increased rates of sporadic mutations [ 43 ]. In a meta-analysis of 13 trials involving nearly 45,000 patients with IBD, the risk of CRC was shown to be approximately three times greater in people with IBD (RR 2.93, 95% CI 1.79–4.81) than in people with no IBD [ 44 ].…”

Section: Risk Factors Of Colorectal Cancermentioning

confidence: 99%

“…Heme iron molecules in red meat can produce carcinogens as well as act as DNA mutagens themselves. PUFAs, bile acids, non-human sialic acid, and infectious pathogens are all potential mechanistic drivers as well [ 43 , 60 ]. To reduce the carcinogenic effects of HCAs, a diet rich in dietary fiber sources such as wheat bran and vegetables is recommended.…”

Section: Risk Factors Of Colorectal Cancermentioning

confidence: 99%

Colorectal Cancer: A Review of Carcinogenesis, Global Epidemiology, Current Challenges, Risk Factors, Preventive and Treatment Strategies

Hossain

Karuniawati

Jairoun

et al. 2022

Cancers

237

152

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Colorectal cancer (CRC) is the second most deadly cancer. Global incidence and mortality are likely to be increased in the coming decades. Although the deaths associated with CRC are very high in high-income countries, the incidence and fatalities related to CRC are growing in developing countries too. CRC detected early is entirely curable by surgery and subsequent medications. However, the recurrence rate is high, and cancer drug resistance increases the treatment failure rate. Access to early diagnosis and treatment of CRC for survival is somewhat possible in developed countries. However, these facilities are rarely available in developing countries. Highlighting the current status of CRC, its development, risk factors, and management is crucial in creating public awareness. Therefore, in this review, we have comprehensively discussed the current global epidemiology, drug resistance, challenges, risk factors, and preventive and treatment strategies of CRC. Additionally, there is a brief discussion on the CRC development pathways and recommendations for preventing and treating CRC.

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“…Furthermore, this paper explores the role of non-coding RNAs in these resistance-related pathways. [61,62,63,64,65] Tyrosine kinase inhibitors (TKIs) were developed and introduced as an oral therapy in clinical settings for the treatment of various cancers, where they are known as "targeted therapies" due to the unique role of receptor tyrosine kinases (RTKs) in tumour development and progression towards its most aggressive phase. [66] It is widely acknowledged that anticancer drugs require adequate absorption at the gastrointestinal (GI) level in order to enter the circulation and, ultimately, to reach the tumour cells.…”

Section: Cancer Drug Resistance and Its Prospective Challengesmentioning

confidence: 99%

Recent Advancement of Colorectal Cancer and Their Herbal Essential Oil Treatment

Kumar¹,

Uniyal²,

Kumar³

2022

J. Res. Appl. Sci. Biotechnol.

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Colorectal cancer is the second most deadly type of cancer (CRC). In the upcoming decades, death and incidence rates would surely increase globally. Despite being disproportionately high in high-income countries, CRC-related mortality is also on the rise in low- and middle-income countries. Early diagnosis of CRC allows for both surgical and medicinal treatment options. Due to the high likelihood of recurrence and the rising rate of treatment failure brought on by cancer medicine resistance, it is regrettable that there is a significant treatment failure rate. Due to early discovery and treatment of CRC, there is a chance of survival in wealthy nations. Contrarily, these resources are noticeably scarce in less developed countries. It is crucial to inform the public about CRC's current situation, its cause, progression, risk factors, and therapy. As a result, we have included in this review all of the most recent data on the global epidemiology, drug resistance, challenges, risk factors, and preventative and therapeutic approaches for CRC. Guidelines for CRC prevention and therapy are briefly reviewed, as well as pathways of CRC developments.

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Risk Factors for Colorectal Cancer

Cited by 5 publications

References 74 publications

Tumefactive Crohn's Disease Mimicking Colon Carcinoma in a Young Female: A Case Report

Tumefactive Crohn's Disease Mimicking Colon Carcinoma in a Young Female: A Case Report

Colorectal Cancer: A Review of Carcinogenesis, Global Epidemiology, Current Challenges, Risk Factors, Preventive and Treatment Strategies

Recent Advancement of Colorectal Cancer and Their Herbal Essential Oil Treatment

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