Risk factors for cardiovascular disease in children with type 1 diabetes in 2000–2010 in Podlasie Province

Polkowska, Agnieszka; Głowińska-Olszewska, Barbara; Tobiaszewska, Monika; Bossowski, Artur

doi:10.18544/pedm-20.02.0002

Cited by 14 publications

(10 citation statements)

References 3 publications

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“…Low vitamin D levels can induce dyslipidemia, and lipid abnormalities, such as a rise in triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) levels and a decrease in high-density lipoprotein cholesterol (HDL-C) levels, have been reported as significant risk factors for atherosclerosis and cardiovascular disease in adults [ 10 , 11 ]. The effects of serum vitamin D status on lipids in Chinese adults were investigated by Wang et al, who discovered that serum 25(OH)-D levels were closely related to lipids and AIP.…”

Section: Discussionmentioning

confidence: 99%

Status of Vitamin D Receptor Gene Polymorphism and 25-Hydroxy Vitamin D Deficiency with Essential Hypertension

et al. 2021

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Essential hypertension (EH) is a multifactorial and complex disease with high rate of incidence and associated co-morbidities. Previous studies do not provide unanimous results for the risk of hypertension and association with Fok I genotype frequency and serum vitamin D levels. Hence, this study was undertaken to determine the status of Fok I vitamin D receptor (VDR) gene polymorphism along with vitamin D levels and blood pressure in patients with EH. Four hundred (200 controls and 200 cases of essential hypertension) participants from general Indian population were enrolled in this study. Peripheral blood samples were collected for genotyping Fok I-VDR gene polymorphism using PCR–RFLP method whereas 25-OH vitamin D levels in serum were quantified using high performance liquid chromatography (HPLC). Significantly reduced 25-OH vitamin D levels were observed in patients with EH (24.04 ± 8.62 vs 50.46 ± 15.46) compared to control subjects ( p = 0.0001). Homozygous recessive genotype ‘ff’ frequency was increased by 8.06 fold (CI: 3.71–17.47, p = 0.0001) in patients with EH compared to dominant ‘FF’ genotype frequency. In conclusion, recessive ‘ff’ genotype frequency correlates with reduced serum vitamin D levels and results in significantly increased systolic and diastolic blood pressures leading to predisposition of EH.

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Section: Discussionmentioning

confidence: 99%

Status of Vitamin D Receptor Gene Polymorphism and 25-Hydroxy Vitamin D Deficiency with Essential Hypertension

et al. 2021

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“…Dyslipidemia frequency in diabetic children varies between 3.8% and 72.5% in different studies [14][15][16][17][18][19], and hypercholesterolemia was reported as the most frequent finding [16,[19][20][21]. Redondo et al found a dyslipidemia prevalence of 3.8% in the US with 11,348 T1D patients aged 2-18 years.…”

Section: Discussionmentioning

confidence: 99%

The prevalence of dyslipidemia and associated factors in children and adolescents with type 1 diabetes

Bulut

Demirel

Metìn

2017

Journal of Pediatric Endocrinology and Metabolism

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Background: Dyslipidemia increases the frequency and severity of micro and macrovascular complications of type 1 diabetes (T1D). The present study aims to determine the prevalence of dyslipidemia and its association with clinical and laboratory findings in diabetic children and adolescents. Methods: The study included 202 children and adolescents with T1D. Demographic data and laboratory findings were obtained from patients files. Results: Dyslipidemia prevalence was found to be 26.2%. Hypercholesterolemia (15.8%) and hyperglyceridemia (12.9%) were most common findings. Age, body mass index (BMI), hemoglobin A 1c (A 1C ) and poor metabolic control were significantly higher in cases with dyslipidemia. Smoking rate was 14.1% in the pubertal group. Poor metabolic control and dyslipidemia was found higher among smokers (p < 0.05).Conclusions: Blood lipid levels should be monitored regularly and nutrition education should be repeated periodically to prevent and control dyslipidemia in patients with T1D. Smoking-related risks should be a part of patient education in the pubertal period.

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“…Vitamin D deficiency is associated with not only cardiovascular disease itself but also cardiovascular risk factors [8,9]. Low vitamin D levels could result in dyslipidemia, and lipid abnormalities—that is, an increase in triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) levels and a decrease in high-density lipoprotein cholesterol (HDL-C) level—have been identified as important risk factors for atherosclerosis and cardiovascular disease in adulthood [10,11].…”

Section: Introductionmentioning

confidence: 99%

Relationship between Vitamin D Level and Lipid Profile in Non-Obese Children

Kim

Jeong

2019

Metabolites

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Vitamin D deficiency is associated with not only cardiovascular disease itself but also cardiovascular risk factors, including obesity, hypertension, diabetes, hyperglycemia, and dyslipidemia. This study aimed to investigate the relationship between vitamin D level and lipid profile in non-obese children. A total of 243 non-obese healthy volunteers, aged 9–18 years, were enrolled from March to May 2017. Their height and weight were measured, and body mass index was calculated. Subjects underwent blood tests, including measurements of vitamin D (25(OH)D) level and lipid panels, and were divided into either the vitamin D-deficient group (<20 ng/mL) or normal group. The student’s t-test and a simple linear regression analysis were used to estimate the association between vitamin D level and lipid profile. Overall, 69.5% of non-obese children (n = 169) had a 25(OH)D level of less than 20 ng/mL. The vitamin D-deficient group showed higher triglyceride (TG) level and TG/high-density lipoprotein cholesterol (HDL-C) ratio than the normal group (TG level: 90.27 vs. 74.74 mmol/L, p = 0.003; TG/HDL-C ratio: 1.753 vs. 1.358, p = 0.003). Vitamin D level seems to affect the lipid profile, even in non-obese children, and a low vitamin D level may progress to dyslipidemia or obesity in non-obese children.

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Risk factors for cardiovascular disease in children with type 1 diabetes in 2000–2010 in Podlasie Province

Abstract: Contemporary patients frequently have excessive body weight and live in families burdened with risk factors for atherosclerosis. Despite the use of modern technology, metabolic control is not satisfactory.

Cited by 14 publications

References 3 publications

Status of Vitamin D Receptor Gene Polymorphism and 25-Hydroxy Vitamin D Deficiency with Essential Hypertension

Status of Vitamin D Receptor Gene Polymorphism and 25-Hydroxy Vitamin D Deficiency with Essential Hypertension

The prevalence of dyslipidemia and associated factors in children and adolescents with type 1 diabetes

Relationship between Vitamin D Level and Lipid Profile in Non-Obese Children

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