Risk factors and management of pulmonary infection in elderly patients with heart failure

Pan, Qi; Qin, Yang

doi:10.1097/md.0000000000027238

Cited by 8 publications

(5 citation statements)

References 45 publications

(76 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since children are less prone to diseases like diabetes, hypertension, or other cardiovascular disease, this portion of the population had a lower risk of developing severe infectious conditions. This data can explain the higher number of severe cases reported among the elderly since they ordinarily suffer from more associated comorbidities [ 15 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

Viral coinfection in hospitalized patients during the COVID-19 pandemic in Southern Brazil: a retrospective cohort study

Rhoden,

Hoffmann,

Stein

et al. 2024

Respir Res

View full text Add to dashboard Cite

Purpose Since the worldwide spread of SARS-CoV-2, different strategies have been followed to combat the pandemic and limit virus transmission. In the meantime, other respiratory viruses continued to circulate, though at decreased rates. Methods This study was conducted between June and July 2022, in a hospital in the metropolitan region of Rio Grande do Sul state, in the southernmost state of Brazil. The 337 hospitalized patients included those with respiratory symptoms without delimitation of age. Reverse transcription-quantitative real-time polymerase chain reaction detected 15 different respiratory viruses and confirmed coinfections in the samples. Different statistical tests were applied to evaluate the association between associations of clinical characteristics and coinfection. Results Sampling corresponds to 337 selected and 330 patients analyzed. The principal clinical outcome found was hospital discharge in 309 (94%) cases, while 21 (6%) resulted in death. The principal viral agents related to coinfections were Human rhinovirus, Human enterovirus, and Respiratory syncytial virus. The most frequent viral agent detected was SARS-CoV-2, with 60 (18%) infections, followed by 51 (15%) cases of Respiratory syncytial virus B (15%) and 44 (13%) cases of Human rhinovirus 1. Coinfection was mainly observed in children, while adults and the elderly were more affected by a single infection. Analyzing COVID-19 vaccination, 175 (53%) were unvaccinated while the remainder had at least one dose of the vaccine. Conclusions This study presents information to update the understanding of viral circulation in the region. Furthermore, the findings clarify the behavior of viral infections and possible coinfections in hospitalized patients, considering different ages and clinical profiles. In addition, this knowledge can help to monitor the population’s clinical manifestations and prevent future outbreaks of respiratory viruses.

show abstract

Section: Discussionmentioning

confidence: 99%

Viral coinfection in hospitalized patients during the COVID-19 pandemic in Southern Brazil: a retrospective cohort study

Rhoden,

Hoffmann,

Stein

et al. 2024

Respir Res

View full text Add to dashboard Cite

show abstract

“…In addition, diminished LVEF and FS and expanded E/A are risk factors for major adverse cardiovascular events [ 33 ]. Likewise, LVEF 55% and CRP 10 mg/L are independent risk factors for pulmonary infection in patients with HF [ 45 ]. Consequently, we further considered the independent correlation between EQPs (LVEF, FS, and E/A) and serum CRP and the occurrence of CHF.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of echocardiography combined with serum C-reactive protein level in chronic heart failure

Zhang

2023

J Cardiothorac Surg

View full text Add to dashboard Cite

Background Chronic heart failure (CHF) is regarded as common clinical heart disease. This study aims to investigate the clinical diagnostic value of echocardiography (Echo) and serum C-reactive protein (CRP) levels in patients with CHF. Methods A total of 75 patients with CHF (42 males, 33 females, age 62.72 ± 1.06 years) were enrolled as study subjects, with 70 non-CHF subjects (38 males, 32 females, age 62.44 ± 1.28 years) as controls. The left ventricular ejection fraction (LVEF), fraction shortening rate of the left ventricle (FS), and early to late diastolic filling (E/A) were determined by Echo, followed by an examination of the expression of serum CRP by ELISA. In addition, the Pearson method was used to analyze the correlation between echocardiographic quantitative parameters (EQPs) (LVEF, FS, and E/A) and serum CRP levels. Receiver operating characteristic (ROC) curve was adopted to evaluate the diagnostic efficacy of EQPs and serum CRP levels for CHF. The independent risk factors for CHF patients were measured by logistics regression analysis. Results The serum CRP level of CHF patients was elevated, the values of LVEF and FS decreased, and the E/A values increased. ROC curve revealed that the EQPs (LVEF, FS, and E/A) combined with serum CRP had high diagnostic values for CHF patients. Logistic regression analysis showed that the EQPs (LVEF, FS, and E/A) and serum CRP levels were independent risk factors for CHF patients. Conclusion Echo combined with serum CRP level has high clinical diagnostic values for CHF patients.

show abstract

“…Of the eleven patients with nonpulmonary infection, only four cases were detected using QmNGS and UmNGS. QmNGS detected viruses only, while UmNGS detected bacteria, viruses, and fungi, including Staphylococcus and Cryptococcus neoformans , which are classified more often as pathogens than viruses in clinics ( Peng and Yang, 2021 ; Zhu et al., 2021 ). This may have provided a misleading anti-infection direction.…”

Section: Discussionmentioning

confidence: 99%

Comparison of quality/quantity mNGS and usual mNGS for pathogen detection in suspected pulmonary infections

Zhao,

Chen,

Wang

et al. 2023

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Improved metagenomic next-generation sequencing (mNGS), for example, quality/quantity mNGS (QmNGS), is being used in the diagnosis of pulmonary pathogens. There are differences between QmNGS and the usual mNGS (UmNGS), but reports that compare their detection performances are rare. In this prospective study of patients enrolled between December 2021 and March 2022, the bronchoalveolar lavage fluid of thirty-six patients with suspected pulmonary infection was assessed using UmNGS and QmNGS. The sensitivity of QmNGS was similar to that of UmNGS. The specificity of QmNGS was higher than that of UmNGS; however, the difference was not statistically significant. The positive likelihood ratios (+LR) of QmNGS and UmNGS were 3.956 and 1.394, respectively, and the negative likelihood ratios (-LR) were 0.342 and 0.527, respectively. For the co-detection of pathogens, the depth and coverage of the QmNGS sequencing were lower than those of UmNGS, while for the detection of pathogens isolated from patients with pulmonary infection, the concordance rate was 77.2%. In the eleven patients with nonpulmonary infection, only viruses were detected using QmNGS, while UmNGS detected not only viruses but also bacteria and fungi. This study provides a basis for the selection of mNGS for the diagnosis of suspected pulmonary infection.

show abstract

Risk factors and management of pulmonary infection in elderly patients with heart failure

Cited by 8 publications

References 45 publications

Viral coinfection in hospitalized patients during the COVID-19 pandemic in Southern Brazil: a retrospective cohort study

Viral coinfection in hospitalized patients during the COVID-19 pandemic in Southern Brazil: a retrospective cohort study

Diagnostic value of echocardiography combined with serum C-reactive protein level in chronic heart failure

Comparison of quality/quantity mNGS and usual mNGS for pathogen detection in suspected pulmonary infections

Contact Info

Product

Resources

About