Risk-benefit assessment of Bacillus Calmette-Guérin vaccination, anti-phenolic glycolipid I serology, and Mitsuda test response: 10-year follow-up of household contacts of leprosy patients

Araújo, Sérgio; Rezende, Marina Monteiro Figueiredo; Sousa, Diogo Carrijo Rodrigues de; Rosa, Maraísa Resende; Santos, Danielle Cristina dos; Goulart, Luíz Ricardo; Goulart, Isabela Maria Bernardes

doi:10.1590/0037-8682-0245-2015

Cited by 31 publications

(45 citation statements)

References 11 publications

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“…There was an increased prevalence of leprosy cases in intradomiciliary contacts when compared with the general population, which was 1.40% in Paraíba in 2012 8 . The prevalence was higher than that found by Düppree et al 6 , Wambier et al 7 , and Araújo et al 9 and lower than that reported by other authors 10,11 .…”

contrasting

confidence: 58%

Importance of epidemiological surveillance of leprosy: analysis of the occurrence of leprosy in intra-domiciliary contacts in a capital in the Brazilian northeast region

Trindade

Martins

Marques

et al. 2020

Rev. Soc. Bras. Med. Trop.

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contrasting

confidence: 58%

Importance of epidemiological surveillance of leprosy: analysis of the occurrence of leprosy in intra-domiciliary contacts in a capital in the Brazilian northeast region

Trindade

Martins

Marques

et al. 2020

Rev. Soc. Bras. Med. Trop.

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“…The anti-PGL-I seropositivity indicates that the bacillus has successfully penetrated the circulatory system, and represents a relative risk almost six times higher for disease occurrence, corroborating the leprosy neuropathy diagnosis. Nevertheless, the number of seropositive patients does not indicate existing infection prevalence, which reached 47.1% of our cases, since paucibacillary patients rarely produce specific antibodies [ 11 , 17 , 26 , 27 , 41 ].…”

Section: Discussionmentioning

confidence: 77%

“…Interestingly, 38.6% of the patients were diagnosed during an epidemiological surveillance and follow-up of household contacts of leprosy patients, supporting the need for control measures and early disease recognition in this high risk population. It is estimated that household contacts of multibacillary patients may present a relative risk of developing leprosy 5 to 10 times higher than the general population [ 25 , 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

Revisiting primary neural leprosy: Clinical, serological, molecular, and neurophysiological aspects

et al. 2017

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BackgroundLeprosy neuropathy is considered the most common peripheral neuropathy of infectious etiology worldwide, representing a public health problem. Clinical diagnosis of primary neural leprosy (PNL) is challenging, since no skin lesions are found and the slit skin smear bacilloscopy is negative. However, there are still controversial concepts regarding the primary-neural versus pure-neural leprosy definition, which will be explored by using multiple clinical-laboratory analyses in this study.Methodology/Principal findingsSeventy patients diagnosed with primary neural leprosy from 2014 to 2016 underwent clinical, laboratorial and neurophysiological evaluation. All patients presented an asymmetric neural impairment, with nerve thickening in 58.6%. Electroneuromyography showed a pattern of mononeuropathy in 51.4%. Positivity for ELISA anti-PGL1 was 52.9%, while the qPCR of slit skin smear was 78.6%. The qPCR of nerve biopsies was positive in 60.8%. Patients with multiple mononeuropathy patterns showed lower levels of anti-PGL-1 (p = 0.0006), and higher frequency of neural thickening (p = 0.0008) and sensory symptoms (p = 0.01) than those with mononeuropathy.Conclusions/SignificancePNL is not a synonym of pure neural leprosy, as this condition may include a generalized immune response and also a skin involvement, documented by molecular findings. Immunological, molecular, and neurophysiological tools must be implemented for diagnosing primary neural leprosy to achieve effective treatment and reduction of its resultant disabilities that still represent a public health problem in several developing nations. Finally, we propose a algorithm and recommendations for the diagnosis of primary neural leprosy based on the combination of the three clinical-laboratorial tools.

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“…In 2015, Araujo et al (25) presented the results of a 10-year follow-up of 2,992 HC. Approximately 1.6% of these HC developed clinical manifestations for the diagnosis of leprosy during the study period.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with seropositivity for APGL-Iamong household contacts of leprosy patients

Wambier

Furini

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Risk-benefit assessment of Bacillus Calmette-Guérin vaccination, anti-phenolic glycolipid I serology, and Mitsuda test response: 10-year follow-up of household contacts of leprosy patients

Cited by 31 publications

References 11 publications

Importance of epidemiological surveillance of leprosy: analysis of the occurrence of leprosy in intra-domiciliary contacts in a capital in the Brazilian northeast region

Importance of epidemiological surveillance of leprosy: analysis of the occurrence of leprosy in intra-domiciliary contacts in a capital in the Brazilian northeast region

Revisiting primary neural leprosy: Clinical, serological, molecular, and neurophysiological aspects

Factors associated with seropositivity for APGL-Iamong household contacts of leprosy patients

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