Factors associated with seropositivity for APGL-Iamong household contacts of leprosy patients

Wambier, Carlos Gustavo; Wambier, Sarah Perillo de Farias; Furini, Renata Bazan; Simão, João Carlos Lopes; Frade, Marco Andrey Cipriani; Foss, Norma Tiraboschi

doi:10.1590/0037-8682-0325-2015

Cited by 7 publications

(8 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There was an increased prevalence of leprosy cases in intradomiciliary contacts when compared with the general population, which was 1.40% in Paraíba in 2012 8 . The prevalence was higher than that found by Düppree et al 6 , Wambier et al 7 , and Araújo et al 9 and lower than that reported by other authors 10,11 .…”

contrasting

confidence: 58%

See 1 more Smart Citation

Importance of epidemiological surveillance of leprosy: analysis of the occurrence of leprosy in intra-domiciliary contacts in a capital in the Brazilian northeast region

Trindade

Martins

Marques

et al. 2020

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

contrasting

confidence: 58%

“…The increased risk of contacts developing leprosy in relation to the general population has been described in Brazil since the 1940s and has been corroborated by several studies over the years 6,7 . In the present study, 4.7% of the contacts were affected by the disease.…”

mentioning

confidence: 59%

Importance of epidemiological surveillance of leprosy: analysis of the occurrence of leprosy in intra-domiciliary contacts in a capital in the Brazilian northeast region

Trindade

Martins

Marques

et al. 2020

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

“…In the same state, seropositivity percentages (ML-flow tests) among child household contacts ranged from 12.3% to 18.6% [48][49][50]. In São Paulo state, 18% of child household contacts tested seropositive (ELISA) [51] whereas this was the case in 14.7% in Rio de Janeiro (ML-dipstick/ML-flow) [52].…”

Section: Latin Americamentioning

confidence: 99%

“…Importantly, six independent studies using different serological tests conducted in (South)eastern Brazil reported similar seropositivity percentages in the range of 10.1 to 18.6% [47][48][49][50][51][52]. Surprisingly, seroprevalence rates did not differ significantly between household contacts and noncontacts.…”

Section: Factors Influencing Seroprevalencementioning

confidence: 99%

Detection of anti-M. leprae antibodies in children in leprosy-endemic areas: A systematic review

et al. 2021

View full text Add to dashboard Cite

Background Leprosy elimination primarily targets transmission of Mycobacterium leprae which is not restricted to patients’ households. As interruption of transmission is imminent in many countries, a test to detect infected asymptomatic individuals who can perpetuate transmission is required. Antibodies directed against M. leprae antigens are indicative of M. leprae infection but cannot discriminate between active and past infection. Seroprevalence in young children, however, reflects recent M. leprae infection and may thus be used to monitor transmission in an area. Therefore, this literature review aimed to evaluate what has been reported on serological tests measuring anti-M. leprae antibodies in children without leprosy below the age of 15 in leprosy-endemic areas. Methods and findings A literature search was performed in the databases Pubmed, Infolep, Web of Science and The Virtual Health Library. From the 724 articles identified through the search criteria, 28 full-text articles fulfilled all inclusion criteria. Two additional papers were identified through snowballing, resulting in a total of 30 articles reporting data from ten countries. All serological tests measured antibodies against phenolic glycolipid-I or synthetic derivatives thereof, either quantitatively (ELISA or UCP-LFA) or qualitatively (ML-flow or NDO-LID rapid test). The median seroprevalence in children in endemic areas was 14.9% and was stable over time if disease incidence remained unchanged. Importantly, seroprevalence decreased with age, indicating that children are a suitable group for sensitive assessment of recent M. leprae infection. However, direct comparison between areas, solely based on the data reported in these studies, was impeded by the use of different tests and variable cut-off levels. Conclusions Quantitative anti-PGL-I serology in young children holds promise as a screening test to assess M. leprae infection and may be applied as a proxy for transmission and thereby as a means to monitor the effect of (prophylactic) interventions on the route to leprosy elimination.

show abstract

“…Seguiu-se a mesma sequência para todos os grupos, só a título de comparação e operacionalização.Inicialmente foram previstas avaliações também no D2 e com tempo total de 21 dias.Após o estudo de indução observou-se que não havia nenhuma alteração macroscópica e nem comportamental dos animais no D2 e, no D28, a epilação e eritema ainda estavam presentes.Optou-se, portanto, por estender o prazo de avaliação em uma semana e retirar as análises do D2. Foram escolhidos intervalos de sete dias por que são comumente utilizados em avaliações do processo inflamatório(WAMBIER et al, 2016).Quaisquer efeitos mecânicos da administração foram considerados e tal enfoque foi alvo de discussão, devido às diferenças inerentes entre as espécies. Este fato permitiu algumas inferências quanto à distinção entre os efeitos mecânicos e as ações físico-químicas, toxicológicas ou farmacodinâmicas da formulação.Antes da radiação, todos os animais foram submetidos à anestesia com cetamina (50mg/mL -80 mg/kg de peso) e xilazina (20mg/mL -10 mg/kg de peso) intraperitoneal e a tricotomia na pata posterior esquerda que seria irradiada, do mesmo modo que foi feito no estudo de indução de radiodermite.Para assegurar que a dose fosse aplicada no local esperado, os animais foram fixados com fitas adesivas numa base acrílica, sob uma placa de chumbo moldável, que permitia que somente uma área de 1,5 x 1,5 cm da pata posterior esquerda ficasse exposta.…”

unclassified

Nanopartículas lipídicas sólidas encapsulando curcuminoides (NLS-CT): estudos in vitro e in vivo

Zamarioli¹

View full text Add to dashboard Cite

DEDICATÓRIA À Deus, que com seus trabalhadores incansáveis, conspirou para a realização de uma pesquisa como esta, partindo de uma aparente "tábula rasa". À todos que poderão ser beneficiados pelo produto que está sendo desenvolvido, podendo ser um alívio nas vidas tão sofridas como as dos pacientes oncológicos. Aos meus pais, que com muito empenho, amor e dedicação permitiram meu retorno ao lar e a minha permanência em tempos difíceis. Meu eterno amor e respeito. Sem vocês nada disto teria sido possível!!!!! Ao meu irmão querido e minha sobrinha tão minha. Família é a alma da gente se expressando através do outro. Muitos dias não pude compartilhar da presença de vocês. Só tenho que pedir desculpas por isso! À enfermagem que, com muita garra, tem tentado melhorar a qualidade de vida dos pacientes contando, por vezes, com um arsenal pequeno numa guerra tão grande. Ao grupo de pesquisa Enfermagem e Comunicação que tem se empenhado em pesquisar temas alternativos, com ousadia e dedicação.

show abstract

Factors associated with seropositivity for APGL-Iamong household contacts of leprosy patients

Cited by 7 publications

References 13 publications

Importance of epidemiological surveillance of leprosy: analysis of the occurrence of leprosy in intra-domiciliary contacts in a capital in the Brazilian northeast region

Importance of epidemiological surveillance of leprosy: analysis of the occurrence of leprosy in intra-domiciliary contacts in a capital in the Brazilian northeast region

Detection of anti-M. leprae antibodies in children in leprosy-endemic areas: A systematic review

Nanopartículas lipídicas sólidas encapsulando curcuminoides (NLS-CT): estudos in vitro e in vivo

Contact Info

Product

Resources

About