Risk assessment of the application of tissue-tolerable plasma on human skin

Lademann, Jürgen; Ulrich, Ch.; Patzelt, Alexa; Richter, Heike; Kluschke, Franziska; Klebes, Martin; Lademann, Olaf; Krämer, Axel; Weltmann, Klaus‐Dieter; Lange‐Asschenfeldt, Bernhard

doi:10.1016/j.cpme.2013.01.001

Cited by 54 publications

(34 citation statements)

References 26 publications

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“…In addition, we refer the reader to the journal "Plasma Medicine", which is a publication started in 2011 devoted entirely to papers on plasma medicine [126]. It is important to note that medical applications of plasmas also bear risks, which should be properly assessed [127]. Besides medical applications, studies on environmental applications have been performed (see e.g.…”

Section: Discussionmentioning

confidence: 99%

20 years of microplasma research: a status report

Schoenbach

Becker²

2016

Eur. Phys. J. D

168

112

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Abstract. The field of microplasmas gained recognition as a well-defined area of research and application within the larger field of plasma science and technology about 20 years ago. Since then, the activity in microplasma research and applications has continuously increased. A survey of peer reviewed papers on microplasmas published annually shows a steady increase from fewer than 20 papers in 1995 to about 75 in 2005 and more than 150 in 2014. This count excludes papers that deal exclusively with technological applications where the microplasma is used solely as a tool. This topical review aims to provide a snap shot of the current state of microplasma research and applications. Given the rapid proliferation of microplasma applications, the topical review will focus primarily on the status of microplasma science and our understanding of the physics principles that enable microplasma operation. Where appropriate, we will also address microplasma applications, however, we will limit the discussion of microplasma applications to examples where the application is closely tied to the plasma science. No attempt is made to provide a comprehensive and in-depth review of the diverse range of all microplasma applications, except for the inclusion of a few key references to recent reviews of microplasma applications.

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Section: Discussionmentioning

confidence: 99%

20 years of microplasma research: a status report

Schoenbach

Becker²

2016

Eur. Phys. J. D

168

112

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“…Cold plasma (CP) offers new aspects of therapy combining potent chemical partial efficacies like UV, IR, reactive species and charged particles has been introduced in medical and biologic applications . Regarding antimicrobial applications first results of plasma treatment of healthy skin or chronic ulcer wounds, respectively, has been reported showing significant antimicrobial efficacy of CP …”

Section: Introductionmentioning

confidence: 99%

In Vitro Susceptibility of Multidrug Resistant Skin and Wound Pathogens Against Low Temperature Atmospheric Pressure Plasma Jet (APPJ) and Dielectric Barrier Discharge Plasma (DBD)

Daeschlein

Napp

Podewils

et al. 2013

Plasma Processes & Polymers

110

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Plasma medicine has become an emerging field in medical sciences since cold plasma has demonstrated important antimicrobial properties. As microbial plasma susceptibility data yet are not available, the susceptibility of 194 wound isolates exhibiting multiple antibiotic resistance was tested in vitro to CP and correlated with inhibition zones. Inhibition zones increased in parallel with the number of antibiotic classes to which the tested strain exhibit resistance. CP exhibited strong antimicrobial efficacy against most important clinical skin and wound pathogens in vitro irrespective of multidrug resistance.

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“…By definition of Lazarus et al, chronic wounds “fail to progress through a normal, orderly, and timely sequence of repair or (…) pass through the repair process without restoring anatomic and functional results.” Local defects in the healing process of chronic wounds, in fibroblast growth, or in blood coagulation contribute to sustained colonization of bacteria which is a burden for patients and an expensive issue for health care systems worldwide . It is hypothesized that plasma promotes the healing process by simultaneous actions: antiseptic effects, enhanced skin cell growth, and induction of mild oxidative stress . Although cells of the immune system are omnipresent in the body, essential for maintaining systemic health, and tightly involved in physiological wound healing, regulation of inflammation, and cytokine responses, investigations have scarcely elucidated the effect of plasma on these cells yet .…”

Section: Introductionmentioning

confidence: 99%

Human Mononuclear Cell Survival and Proliferation is Modulated by Cold Atmospheric Plasma Jet

Bekeschus

Masur

Kolata

et al. 2013

Plasma Processes & Polymers

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Cold plasma has become a promising application in the fields of biology and medicine. Its anti‐microbial effects and stimulating properties on eukaryotic cells make plasma an encouraging option in treatment of chronic wounds. Apart from fibroblasts or keratinocytes, immune cells have a major contribution in wound healing. In this study, human peripheral blood mononuclear cells (PBMC) were tested for viability and proliferation after treatment with an atmospheric pressure argon plasma jet. In a treatment time dependent manner compromised viability of PBMC and proliferation of T cells could be shown and was assigned to induced apoptosis. Negligible cell damage was observed after short plasma exposure. Finally, plasma did not cause loss of function and treated but viable T cells retained the ability to proliferate.

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Risk assessment of the application of tissue-tolerable plasma on human skin

Cited by 54 publications

References 26 publications

20 years of microplasma research: a status report

20 years of microplasma research: a status report

In Vitro Susceptibility of Multidrug Resistant Skin and Wound Pathogens Against Low Temperature Atmospheric Pressure Plasma Jet (APPJ) and Dielectric Barrier Discharge Plasma (DBD)

Human Mononuclear Cell Survival and Proliferation is Modulated by Cold Atmospheric Plasma Jet

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