Risikofaktorer for blødende magesår

Søberg, Taran; Hofstad, Bjørn; Sandvik, Leiv; Johansen, Maren; Lygren, Idar

doi:10.4045/tidsskr.08.0693

Cited by 6 publications

(2 citation statements)

References 29 publications

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“…The peptic ulcer, characterized by mucosal damage, is predominantly caused by Helicobacter pylori , antiplatelet agents such as acetylsalicylic acid [1], nonsteroidal anti-inflammatory drugs (NSAIDs) such as oral bisphosphonates, potassium chloride, immunosuppressive medications [2, 3], serotonin reuptake inhibitors [4], alcohol consumption, and cigarette smoking (for review, see [5]). Anatomically, the ulcers mostly occur in the stomach and proximal duodenum.…”

Section: Introductionmentioning

confidence: 99%

Acute Toxicity and Gastroprotective Role ofM. pruriensin Ethanol-Induced Gastric Mucosal Injuries in Rats

Golbabapour

Hajrezaie

Hassandarvish

et al. 2013

BioMed Research International

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The investigation was to evaluate gastroprotective effects of ethanolic extract of M. pruriens leaves on ethanol-induced gastric mucosal injuries in rats. Forty-eight rats were divided into 8 groups: negative control, extract control, ulcer control, reference control, and four experimental groups. As a pretreatment, the negative control and the ulcer control groups were orally administered carboxymethylcellulose (CMC). The reference control was administered omeprazole orally (20 mg/kg). The ethanolic extract of M. pruriens leaves was given orally to the extract control group (500 mg/kg) and the experimental groups (62.5, 125, 250, and 500 mg/kg). After 1 h, CMC was given orally to the negative and the extract control groups. The other groups received absolute ethanol. The rats were sacrificed after 1 h. The ulcer control group exhibited significant mucosal injuries with decreased gastric wall mucus and severe damage to the gastric mucosa. The extract caused upregulation of Hsp70 protein, downregulation of Bax protein, and intense periodic acid schiff uptake of glandular portion of stomach. Gastric mucosal homogenate showed significant antioxidant properties with increase in synthesis of PGE2, while MDA was significantly decreased. The ethanolic extract of M. pruriens leaves was nontoxic (<5 g/kg) and could enhance defensive mechanisms against hemorrhagic mucosal lesions.

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Section: Introductionmentioning

confidence: 99%

Acute Toxicity and Gastroprotective Role ofM. pruriensin Ethanol-Induced Gastric Mucosal Injuries in Rats

Golbabapour

Hajrezaie

Hassandarvish

et al. 2013

BioMed Research International

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“…One of the side effects of NSAIDs is gastrointestinal mucosal injury. There are many reports on gastric mucosal injury, which easily manifests clinically [21][22][23]. However, NSAIDs actually cause tissue damage not only in the stomach but also in the small intestine.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-13 Mediates Non-Steroidal Anti-Inflammatory-Drug-Induced Small Intestinal Mucosal Injury with Ulceration

Kawashima,

Tamaki,

Hara

et al. 2023

IJMS

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Non-steroidal anti-inflammatory drugs (NSAIDs), which are antipyretics and analgesics, cause gastrointestinal disorders, such as inflammation and ulcers. To prescribe NSAIDs more safely, it is important to clarify the mechanism of NSAID-induced gastrointestinal mucosal injury. However, there is a paucity of studies on small intestinal mucosal damage by NSAIDs, and it is currently unknown whether inflammation and ulceration also occur in the small intestine, and whether mediators are involved in the mechanism of injury. Therefore, in this study, we created an animal model in which small intestinal mucosal injury was induced using NSAIDs (indomethacin; IDM). Focusing on the dynamics of immune regulatory factors related to the injury, we aimed to elucidate the pathophysiological mechanism involved. We analyzed the pathological changes in the small intestine, the expression of immunoregulatory factors (cytokines), and identified cytokine secretion and expression cells from isolated lamina propria mononuclear cells (LPMCs). Ulcers were formed in the small intestine by administering IDM. Although the mRNA expression levels of IL-1β, IL-6, and TNFα were decreased on day 7 after IDM administration, IL-13 mRNA levels increased from day 3 after IDM administration and remained high even on day 7. The IL-13 mRNA expression and the secretion of IL-13 were increased in small intestinal LPMCs isolated from the IDM-treated group. In addition, we confirmed that IL-13 was expressed in CD4-positive T cells. These results provided new evidence that IL-13 production from CD4-positive T cells in the lamina propria of the small intestine contributes to NSAID-induced mucosal injury.

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Gastrointestinal bleeding due to peptic ulcers and erosions – a prospective observational study (BLUE study)

Romstad

Detlie

Søberg

et al. 2020

Scandinavian Journal of Gastroenterology

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Objectives: Acute upper gastrointestinal bleeding is a well-recognized complication of peptic ulcers and erosions. The aim of this study was to assess the incidence rate and identify risk factors for this complication in southeastern Norway. Materials and methods: Between March 2015 and December 2017, a prospective observational study was conducted at two Norwegian hospitals with a total catchment area of approximately 800,000 inhabitants. Information regarding patient characteristics, comorbidities, drug use, H. pylori status and 30-day mortality was recorded. Results: A total of 543 adult patients were included. The incidence was 30/100,000 inhabitants per year. Altogether, 434 (80%) of the study patients used risk medication. Only 46 patients (8.5%) used proton pump inhibitors (PPIs) for more than 2 weeks before the bleeding episode. H. pylori testing was performed in 527 (97%) patients, of whom 195 (37%) were H. pylori-positive. The main comorbidity was cardiovascular disease. Gastric and duodenal ulcers were found in 183 (34%) and 275 (51%) patients, respectively. Simultaneous ulcerations at both locations were present in 58 (10%) patients, and 27 (5%) had only erosions. Overall, the 30-day mortality rate was 7.6%. Conclusions: The incidence of upper gastrointestinal bleeding due to peptic ulcers and erosions was found to be lower than previously demonstrated in comparable studies, but the overall mortality rate was unchanged. The consumption of risk medication was high, and only a few patients had used prophylactic PPIs. Concurrent H. pylori infection was present in only one-third of the patients. Clinical trial registration: Bleeding Ulcer and Erosions Study 'BLUE Study', ClinicalTrials.gov Identifier. NCT03367897.

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Risikofaktorer for blødende magesår

Cited by 6 publications

References 29 publications

Acute Toxicity and Gastroprotective Role ofM. pruriensin Ethanol-Induced Gastric Mucosal Injuries in Rats

Acute Toxicity and Gastroprotective Role ofM. pruriensin Ethanol-Induced Gastric Mucosal Injuries in Rats

Interleukin-13 Mediates Non-Steroidal Anti-Inflammatory-Drug-Induced Small Intestinal Mucosal Injury with Ulceration

Gastrointestinal bleeding due to peptic ulcers and erosions – a prospective observational study (BLUE study)

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