2023
DOI: 10.3390/ijms241914971
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Interleukin-13 Mediates Non-Steroidal Anti-Inflammatory-Drug-Induced Small Intestinal Mucosal Injury with Ulceration

Rei Kawashima,
Shun Tamaki,
Yusuke Hara
et al.

Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs), which are antipyretics and analgesics, cause gastrointestinal disorders, such as inflammation and ulcers. To prescribe NSAIDs more safely, it is important to clarify the mechanism of NSAID-induced gastrointestinal mucosal injury. However, there is a paucity of studies on small intestinal mucosal damage by NSAIDs, and it is currently unknown whether inflammation and ulceration also occur in the small intestine, and whether mediators are involved in the mechanism o… Show more

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“…NSAIDs have been observed to induce tissue oxidation, which is considered a significant detrimental impact within the gastrointestinal tract [88]. This results in gastric mucosal injuries, including hemorrhage, ulceration and erosion, through the expedited generation of hydrogen peroxide, lipid peroxidation, and protein oxidation.…”
Section: Plos Onementioning
confidence: 99%
“…NSAIDs have been observed to induce tissue oxidation, which is considered a significant detrimental impact within the gastrointestinal tract [88]. This results in gastric mucosal injuries, including hemorrhage, ulceration and erosion, through the expedited generation of hydrogen peroxide, lipid peroxidation, and protein oxidation.…”
Section: Plos Onementioning
confidence: 99%