The main objective of this study was to evaluate the association between job satisfaction and accidents at work among nursing professionals in the hospital area in the interior of Minas Gerais. This was a descriptive-analytical cross-sectional study with a quantitative approach, with data collected in 2018. Data collection was used to characterize the workers and the Job Satisfaction Questionnaire S20 / 23, validated to Brazil. Statistical tests were applied. It was evident that of the 451 participants in this study, the majority were nursing technicians, female, between the ages of 19 and 39, married / companions, without children, Catholics, working in the morning, in the wards of hospitalization, fulfilling 36 hours a week, with up to 5 years of training and performance in the hospital and family income between a salary and a half to three minimum salaries, this being his only job. These amounts corresponded to R$ 1431.00 to R$ 2862.00 on the date of collection. A minority has been injured in the last twelve months, and this occurred mainly in the afternoon. In general, the workers reported the accidents and reported their bosses to them; the main type of accident was "with body fluids", followed by those with sharp objects, being the lack of attention of third parties and training, the reasons for these occurrences. Most of the accident victims did not leave nor had sequels due to these accidents. The average satisfaction of nursing workers was high, and the Inner Work Satisfaction and Physical Environment dimensions were the most relevant, followed by Satisfaction with Hierarchical Relationships, demonstrating the considerable job satisfaction of nursing professionals. There was a significant association between Accidents at work and nursing profession time and the time spent in the hospital. There was an association between job satisfaction and the Catholic religion, the existence of children, the professional category of nurses and specialized sectors such as Intensive Care Unit, Hemodialysis and Surgical Center. The association between satisfaction and occurrence of an occupational accident has not been proven. Identifying actions that promote satisfaction in hospital work can positively influence the final quality of care offered by nursing workers, productivity and physical and mental health of these people.