Riluzole Normalizes Early-Life Stress-Induced Visceral Hypersensitivity in Rats: Role of Spinal Glutamate Reuptake Mechanisms

Behavioural and neurochemical consequences of chronic gut microbiota depletion during adulthood in the rat

“…The hot plate test was used to assess somatic pain sensitivity and was carried out as previously described (Gosselin et al, 2010). Animals were placed on a hot plate with all four paws facing the plate.…”

Maternal separation as a model of brain–gut axis dysfunction

“…It has been shown that MS rats suffer from stress-induced visceral hyperalgesia and increased colonic motility that mimics IBS in human (Gosselin et al 2010;O'Mahony et al 2009;Schwetz et al 2005;Tjong et al 2010). Moreover, it has been shown that female rats are more sensitive to CRD than their male counterparts (Rosztoczy et al 2003).…”

“…Recently, it has been shown that MS results in a decrease in the levels of the glial glutamate transporter EAAT1 in the spinal cord (Gosselin et al 2010). Moreover, the EAAT activator riluzole reversed MS-induced visceral hypersensitivity (Gosselin et al 2010).…”

Current state of pharmacology and therapeutics in irritable bowel syndrome with special reference to brain-gut axis

“…Recently, riluzole (glutamate uptake enhancer and NMDA receptor antagonist) was proposed to improve visceral hypersensitivity symptoms in animal models. 38 A small clinical comparative effectiveness study on 108 patients indicates superiority of "add on riluzole regimen" to standard IBS therapy, in relieving diarrheal and pain symptoms compared to "add on amitriptyline" or the standard therapy alone. 39 The dorsal horn of the spinal cord is a critical area in which the modulation of sensitivity can occur.…”