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Cited by 194 publications
(176 citation statements)
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References 72 publications
(110 reference statements)
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“…[90] Additional preclinical studies have shown that anxiety-and/or depression-like behaviors are also altered by certain probiotic treatments, [62] prebiotics, [91][92][93] and antibiotics. [94] In humans, alterations in the microbiota have been observed across a variety of amygdala-related clinical disorders, including depression. [90] In addition, the composition of the microbiota is associated with differences in affective responses to unpleasant emotional images in healthy females.…”
Section: Anxiety-and Depression-like Behavior Are Regulated By Gut MImentioning
confidence: 99%
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“…[90] Additional preclinical studies have shown that anxiety-and/or depression-like behaviors are also altered by certain probiotic treatments, [62] prebiotics, [91][92][93] and antibiotics. [94] In humans, alterations in the microbiota have been observed across a variety of amygdala-related clinical disorders, including depression. [90] In addition, the composition of the microbiota is associated with differences in affective responses to unpleasant emotional images in healthy females.…”
Section: Anxiety-and Depression-like Behavior Are Regulated By Gut MImentioning
confidence: 99%
“…[90,96] Finally, different probiotic strains have been shown to reduce symptoms of anxiety and depression across several studies in clinical and healthy populations. [97,98] While there have also [5,9,10,88,90] Anxiolytic effects, sometimes sex-specific, in mice (light-dark box, elevated-plus maze) [72,113] Anxiolytic effects in mice (open field, defensive marble burying, elevated-plus maze, light-dark box) [91,93] Strain-specific anxiolytic effects in humans (e.g., Beck Anxiety Index, Hospital Anxiety & Depression Scale) and rodents (defensive marble burying, elevated-plus maze, open field) [11,62,133,134] Transplant from humans with depression or comorbid IBS and anxiety increases anxietylike behavior in mice (open field, step-down test, light-dark box) [96,125] Heightened anxiety in rats (open field) [89] Depression Increased depressive-like behavior in mice (forced swim) [90] Increased depressive-like behavior in rats (forced swim) [94] Antidepressant effects in mice and rats (forced swim, tail suspension, learned helplessness after inescapable shock) [91,92] Strain-specific antidepressant effects in humans (e.g. Beck Depression Inventory, Hospital Anxiety & Depression Scale) and rodents (tail suspension test, forced swim, sucrose preference) [11,97,98,133,134] Transplant from depressed human donors induces depressive-like behavior in mice (sucrose preference, forced swim [varied results], tail suspension test) [90,96] Learned fear Impaired fear recall in adult mice [101] Acute administration enhances fear extinction in rodents and exposure therapy in humans, [103,104] reduces fear recall in huma...…”
Section: Anxiety-and Depression-like Behavior Are Regulated By Gut MImentioning
confidence: 99%
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