Rifampicin Enhanced Carbapenem Activity with Improved Antibacterial Effects and Eradicates Established Acinetobacter baumannii Biofilms

Nwabor, Lois Chinwe; Chukamnerd, Arnon; Nwabor, Ozioma Forstinus; Pomwised, Rattanaruji; Voravuthikunchai, Supayang Piyawan; Chusri, Sarunyou

doi:10.3390/ph16040477

Cited by 2 publications

(1 citation statement)

References 35 publications

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“…These findings can be explained by considering a previous in vitro study that found serum resistance by biofilm formation against complement activity of the human immune system 23 . Additionally, whole genome sequencing analysis showed the presence of the genes responsible for biofilm formation, serum resistance, other virulence‐associated genes, and various antimicrobial resistance genes among A. baumannii isolates causing bacteremia or pneumonia 17,24,25 …”

Section: Discussionmentioning

confidence: 86%

Association of biofilm formation, antimicrobial resistance, clinical characteristics, and clinical outcomes among Acinetobacter baumannii isolates from patients with ventilator‐associated pneumonia

Chukamnerd,

Saipetch,

Singkhamanan

et al. 2024

Clinical Respiratory J

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IntroductionBiofilm formation is an important virulence factor of Acinetobacter baumannii. Here, we examined the biofilm formation of archived A. baumannii causing ventilator‐associated pneumonia (VAP).MethodsEighteen and twenty isolates of A. baumannii causing bacteremic pneumonia and non‐bacteremic pneumonia were included, respectively. Antimicrobial susceptibility testing was performed by broth microdilution method, while biofilm formation was evaluated by microtiter dish biofilm formation assay.ResultsAll 38 isolates were still susceptible to colistin and tigecycline, whereas almost all isolates were non‐susceptible (intermediate to resistant) to several antimicrobial agents, especially ceftriaxone and cefotaxime. Approximately, 44% of bacteremic isolates and 50% of non‐bacteremic isolates were classified as carbapenem‐resistant A. baumannii (CRAB). Biofilm formation was detected in 42% of the studied isolates. Bacteremia among the patients infected with biofilm‐producing isolates was significantly higher than in those infected with non‐biofilm‐producing isolates. The antimicrobial susceptibilities of A. baumannii with biofilm formation were lower than those without biofilm formation, but the differences did not have statistical significance. The patients infected with non‐biofilm‐producing isolates had good clinical and non‐clinical outcomes than those infected with biofilm‐producing isolates. The survival rate of patients diagnosed with VAP due to biofilm‐producing A. baumannii was lower than in those patients diagnosed with VAP due to non‐biofilm‐producing isolates.ConclusionBiofilm formation of A. baumannii causing VAP was associated with antimicrobial resistance and bacteremia as well as unfavorable clinical outcomes.

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Section: Discussionmentioning

confidence: 86%

Association of biofilm formation, antimicrobial resistance, clinical characteristics, and clinical outcomes among Acinetobacter baumannii isolates from patients with ventilator‐associated pneumonia

Chukamnerd,

Saipetch,

Singkhamanan

et al. 2024

Clinical Respiratory J

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Recent Strategies Inhibiting Quorum Sensing and Biofilm Formation in Bacteria to Combat Antibacterial Drug Resistance

Tiwari,

Deshpande,

Gidwani

et al. 2024

Advances in Medical Technologies and Clinical Practice

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Antibacterial drug resistance is a global issue that arises as bacteria adapt over time to certain medications, making illnesses more difficult to cure and raising the possibility of contracting a disease, getting sick, or possibly dying. Quorum-sensing communication routes are used by bacteria to control a variety of physiological processes and it relies on bacterial receptors, which are manufactured by bacteria, to recognize small signaling molecules called autoinducers. The activation of the genes necessary for biofilm formation occurs when autoinducers bind to receptors. The purpose and concentration of the chapter is to comprehend the process underlying the development of biofilms brought on by the quorum sensing system, which gives both gram-positive and negative microorganisms resistance to antibacterial medications. It also examines recent developments and strategies for bacterial biofilm breakdown with an emphasis on quorum-sensing inhibitors.

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Rifampicin Enhanced Carbapenem Activity with Improved Antibacterial Effects and Eradicates Established Acinetobacter baumannii Biofilms

Cited by 2 publications

References 35 publications

Association of biofilm formation, antimicrobial resistance, clinical characteristics, and clinical outcomes among Acinetobacter baumannii isolates from patients with ventilator‐associated pneumonia

Association of biofilm formation, antimicrobial resistance, clinical characteristics, and clinical outcomes among Acinetobacter baumannii isolates from patients with ventilator‐associated pneumonia

Recent Strategies Inhibiting Quorum Sensing and Biofilm Formation in Bacteria to Combat Antibacterial Drug Resistance

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