Recent Strategies Inhibiting Quorum Sensing and Biofilm Formation in Bacteria to Combat Antibacterial Drug Resistance

Abstract

Antibacterial drug resistance is a global issue that arises as bacteria adapt over time to certain medications, making illnesses more difficult to cure and raising the possibility of contracting a disease, getting sick, or possibly dying. Quorum-sensing communication routes are used by bacteria to control a variety of physiological processes and it relies on bacterial receptors, which are manufactured by bacteria, to recognize small signaling molecules called autoinducers. The activation of the genes necessary for biofilm formation occurs when autoinducers bind to receptors. The purpose and concentration of the chapter is to comprehend the process underlying the development of biofilms brought on by the quorum sensing system, which gives both gram-positive and negative microorganisms resistance to antibacterial medications. It also examines recent developments and strategies for bacterial biofilm breakdown with an emphasis on quorum-sensing inhibitors.