Ridge Preservation After Tooth Extraction With Buccal Bone Plate Deficiency Using Tunnel Structured β‐Tricalcium Phosphate Blocks: A 2‐Month Histologic Pilot Study in Beagle Dogs

Ikawa, Takahiro; Akizuki, Tanetaka; Matsuura, Takanori; Hoshi, Shu; Ammar, Shujaa Addin; Kinoshita, Atsuhiro; Oda, Shigeru; Izumi, Yuichi

doi:10.1902/jop.2015.150246

Cited by 12 publications

(22 citation statements)

References 44 publications

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“…ARP aims to minimize external resorption of the ridge and to maximize bone formation within the socket. Various techniques have been described in literature, frequently varying greatly in difficulty and biomaterials used (Jung et al 2013, Barone et al 2015c, Canullo et al 2015, Ikawa et al 2015, Lee et al 2015, Mendoza-Azpur et al 2015, Sbordone et al 2015. The use of autologous bone particles did not significantly alter the ridge resorptive process (Ara ujo & Lindhe, 2011).…”

Section: Discussionmentioning

confidence: 99%

The use of leucocyte and platelet‐rich fibrin in socket management and ridge preservation: a split‐mouth, randomized, controlled clinical trial

Temmerman

Vandessel

Castro

et al. 2016

J Clinic Periodontology

155

214

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Section: Discussionmentioning

confidence: 99%

The use of leucocyte and platelet‐rich fibrin in socket management and ridge preservation: a split‐mouth, randomized, controlled clinical trial

Temmerman

Vandessel

Castro

et al. 2016

J Clinic Periodontology

155

214

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“…Placement of biomaterials into jeopardized extraction sockets has been shown to reduce the degree of the ridge alterations and prevent soft tissue ingrowth (Ikawa et al, ; Lee, Jung, et al, ; Takahashi, Marukawa, & Omura, ). The application of barrier membranes has further been suggested to prevent soft tissue invasion endeavored especially when there is the absence of the buccal bony wall (Darby, Chen, & Buser, ).…”

Section: Discussionmentioning

confidence: 99%

Recombinant human BMP9 (RhBMP9) in comparison with rhBMP2 for ridge augmentation following tooth extraction: An experimental study in the Beagle dog

Saulačić

Benoit

Muñoz

et al. 2018

Clinical Oral Implants Res

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Objectives The purpose of this study was to compare the effects of rhBMP2 with rhBMP9 on ridge augmentation following healing of extraction sockets in dogs. Material and methods Five male Beagle dogs, approximately 12 months of age, were used. The mesial roots of the four maxillary premolars were endodontically treated. The distal roots were extracted, and the buccal bony walls removed. All extraction sockets were filled with deproteinized bovine bone mineral (DBBM). A collagen membrane was soaked with 4 μg or 20 μg of rhBMP9, 20 μg of rhBMP2 or sterile saline and placed over the augmented sites. All animals were euthanized after 8 weeks of healing and investigated by micro‐CT and histologic analysis. A one‐way ANOVA with Tukey's HSD post hoc test was used to compare the differences between the four groups. Results New bone apposition in all defects was observed from the original bone. RhBMP samples showed an increase in bone formation in the buccal area and better integration of DBBM particles when compared to control sites. Both rhBMP9 defects showed higher values of bone (p = 0.024), bone marrow (p = 0.044), and total augmentation volume (p = 0.033) than the rhBMP2 (20 μg) or control sites. Highest bone area was found in rhBMP9 defects (p = 0.895). Conclusions Within the limitations of the present study, rhBMP9 sites demonstrated higher bone‐inducing potential in combination with DBBM than rhBMP2. While rhBMP9s failed to demonstrate a clear dose‐response relationship to the outcomes, future studies are necessary to evaluate the appropriate dose and carrier systems.

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“…Lidocaine hydrochloride (2% with 1:80,000 epinephrine) was administered as a local anesthetic. Experimental defects were prepared as described in a previous study . In each dog, an intracrevicular incision was made from the maxillary canine to the second premolar, and a mucoperiosteal flap was elevated.…”

Section: Methodsmentioning

confidence: 99%

“…In addition, this resorptive process often results in a more lingually relocated alveolar ridge . In beagle dogs, it has been shown that pronounced dimensional remodeling occurs at extraction sockets with buccal bone deficiency when graft materials are not used . Various alveolar ridge preservation techniques following tooth extractions have been developed to date .…”

Section: Introductionmentioning

confidence: 99%

Ridge preservation of extraction sockets with buccal bone deficiency using poly lactide‐co‐glycolide coated β‐tricalcium phosphate bone grafts: An experimental study in dogs

Okada

Matsuura

Akizuki

et al. 2019

Journal of Periodontology

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Background:The alveolar ridge undergoes pronounced reduction in height and width following tooth extraction. This study aims to comparatively evaluate the potential for ridge preservation in extraction sockets with buccal bone deficiency of -tricalcium phosphate coated with poly lactide-co-glycolide ( -TCP/PLGA) and conventional particulate -TCP. Methods:In six beagles, maxillary first premolars were extracted after removal of their buccal bone plates. Standardized bone defects (4 [mesiodistal width] × 4 [buccopalatal width] × 5 [depth] mm) were created at the sites of extraction sockets and filled with -TCP/PLGA (test sites) or particulate -TCP (control sites). Microcomputed tomography, histologic, and histometric evaluations were performed 12 weeks post-surgery. Results:The test sites exhibited a significantly greater bone volume than the control sites (25.7 ± 2.14 versus 16.0 ± 3.3 mm 3 ), although no statistically significant difference was detected in bone material density (746.3 ± 23.9 versus 714.5 ± 37.0 g/cm 3 , respectively). Relative to the control sites, the test sites exhibited significantly greater alveolar-ridge coronal (2.0 ± 0.4 versus 1.1 ± 0.3 mm) and middle (2.9 ± 0.2 versus 2.1 ± 0.3 mm) horizontal widths and proportions of woven bone (50.3 ± 8.1% versus 38.0 ± 5.2%) and bone marrow (17.7 ± 6.6% versus 9.7 ± 4.1%) but a significantly lower proportion of connective tissue (10.7 ± 4.5% versus 18.3 ± 5.7%). Conclusion:Within the limitations of this study, the moldable -TCP/PLGA graft appears to exhibit a greater potential than the conventional particulate -TCP graft for ridge preservation of extraction sockets with buccal bone deficiency. K E Y W O R D Salveolar ridge augmentation, -tricalcium phosphate, biocompatible materials, dogs, osteogenesis, tooth extraction 1014

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Ridge Preservation After Tooth Extraction With Buccal Bone Plate Deficiency Using Tunnel Structured β‐Tricalcium Phosphate Blocks: A 2‐Month Histologic Pilot Study in Beagle Dogs

Abstract: Tunnel β-TCP blocks represent an effective bone-graft material for alveolar ridge preservation in fresh extraction sockets with buccal bone defects.

Cited by 12 publications

References 44 publications

The use of leucocyte and platelet‐rich fibrin in socket management and ridge preservation: a split‐mouth, randomized, controlled clinical trial

The use of leucocyte and platelet‐rich fibrin in socket management and ridge preservation: a split‐mouth, randomized, controlled clinical trial

Recombinant human BMP9 (RhBMP9) in comparison with rhBMP2 for ridge augmentation following tooth extraction: An experimental study in the Beagle dog

Ridge preservation of extraction sockets with buccal bone deficiency using poly lactide‐co‐glycolide coated β‐tricalcium phosphate bone grafts: An experimental study in dogs

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