Riboflavin carrier protein: A serum and tissue marker for breast carcinoma

Karande, Anjali A.; Sridhar, Lakshmi N.; Gopinath, K. S.; Adiga, P. Radhakantha

doi:10.1002/1097-0215(20010920)95:5<277::aid-ijc1047>3.0.co;2-y

Cited by 45 publications

(41 citation statements)

References 23 publications

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“…Riboflavin is an essential vitamin for cellular metabolism, and the riboflavin carrier protein (RCP) is highly upregulated in metabolically active cells 104,105. Thus, flavin mononucleotide (FMN), an endogenous RCP ligand, was used as a small molecule targeting ligand for metabolically active cancer or endothelial cells.…”

Section: Types Of Targeting Moietiesmentioning

confidence: 99%

Targeting Strategies for Multifunctional Nanoparticles in Cancer Imaging and Therapy

Park²,

2012

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Nanomaterials offer new opportunities for cancer diagnosis and treatment. Multifunctional nanoparticles harboring various functions including targeting, imaging, therapy, and etc have been intensively studied aiming to overcome limitations associated with conventional cancer diagnosis and therapy. Of various nanoparticles, magnetic iron oxide nanoparticles with superparamagnetic property have shown potential as multifunctional nanoparticles for clinical translation because they have been used asmagnetic resonance imaging (MRI) constrast agents in clinic and their features could be easily tailored by including targeting moieties, fluorescence dyes, or therapeutic agents. This review summarizes targeting strategies for construction of multifunctional nanoparticles including magnetic nanoparticles-based theranostic systems, and the various surface engineering strategies of nanoparticles for in vivo applications.

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Section: Types Of Targeting Moietiesmentioning

confidence: 99%

Targeting Strategies for Multifunctional Nanoparticles in Cancer Imaging and Therapy

Park²,

2012

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“…[20][21][22] Due to its involvement in cell growth and development, RF is of high demand in metabolically active cells such as various malignant (eg, breast, prostate cancer, and hepatocellular carcinoma) and rapidly growing endothelial cells. [23][24][25][26] Thus, a major argument for using RF as a ligand for targeted drug delivery is that it targets both cancerous cells and the tumor stroma including the angiogenic endothelium. 19,27,28 This feature was demonstrated in several preclinical studies with a variety of used carriers -from iron oxide nanoparticles to polymers.…”

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confidence: 99%

Photoacoustic imaging of tumor targeting with riboflavin-functionalized theranostic nanocarriers

Beztsinna

Tsvetkova

Jose

et al. 2017

IJN

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Photoacoustic imaging is an emerging method in the molecular imaging field, providing high spatiotemporal resolution and sufficient imaging depths for many clinical applications. Therefore, the aim of this study was to use photoacoustic imaging as a tool to evaluate a riboflavin (RF)-based targeted nanoplatform. RF is internalized by the cells through a specific pathway, and its derivatives were recently shown as promising tumor-targeting vectors for the drug delivery systems. Here, the RF amphiphile synthesized from a PEGylated phospholipid was successfully inserted into a long-circulating liposome formulation labeled with the clinically approved photoacoustic contrast agent – indocyanine green (ICG). The obtained liposomes had a diameter of 124 nm (polydispersity index =0.17) and had a negative zeta potential of −26 mV. Studies in biological phantoms indicated a stable and concentration-dependent photoacoustic signal (Vevo ® LAZR) of the ICG-containing RF-functionalized liposomes. In A431 cells, a high uptake of RF-functionalized liposomes was found and could be blocked competitively. First, studies in mice revealed ~3 times higher photoacoustic signal in subcutaneous A431 tumor xenografts ( P <0.05) after injection of RF-functionalized liposomes compared to control particles. In this context, the application of a spectral unmixing protocol confirmed the initial quantitative data and improved the localization of liposomes in the tumor. In conclusion, the synthesized RF amphiphile leads to efficient liposomal tumor targeting and can be favorably detected by photoacoustic imaging with a perspective of theranostic applications.

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“…It is taken up with high efficiency by riboflavin binding proteins (RBP; MW = 27.5 ~ 40 kDa, K d ≈ 1 nM) that are present as both soluble or membrane-bound forms,17, 18 referred to as either RF carrier protein19, 20 or RF transporter21. Prior studies based on RF conjugates composed of RF linked to rhodamin dye22, or albumin protein23 suggest that such RF conjugates are taken up by cells after interacting with a RF receptor.…”

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confidence: 99%

Design of riboflavin-presenting PAMAM dendrimers as a new nanoplatform for cancer-targeted delivery

Thomas

Choi

et al. 2010

Bioorganic & Medicinal Chemistry Letters

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This communication describes the synthesis and in vitro biological evaluation of novel generation 5 PAMAM dendrimers conjugated with riboflavin as a targeting ligand. Cell-based experiments demonstrated that a dendrimer conjugated with riboflavin is able to undergo cellular binding and uptake in KB cells, and when the dendrimer is also conjugated with methotrexate, the riboflavin dendrimer conjugate can potently inhibit cell growth.

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Riboflavin carrier protein: A serum and tissue marker for breast carcinoma

Cited by 45 publications

References 23 publications

Targeting Strategies for Multifunctional Nanoparticles in Cancer Imaging and Therapy

Targeting Strategies for Multifunctional Nanoparticles in Cancer Imaging and Therapy

Photoacoustic imaging of tumor targeting with riboflavin-functionalized theranostic nanocarriers

Design of riboflavin-presenting PAMAM dendrimers as a new nanoplatform for cancer-targeted delivery

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