Rhinoplasty Model in Rabbit

Çöloğlu, Harun; Uysal, Ahmet Çağrı; Koçer, Uğur; Kankaya, Yüksel; Oruç, Melike; Uysal, Selma

doi:10.1097/01.prs.0000221875.24467.2d

Cited by 21 publications

(19 citation statements)

References 13 publications

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“…Several animal models are used in rhinoplasty and nose cartilage tissue-engineering studies. Rabbit models are frequently used due to their affordability and availability, and surgical procedures for rabbits are well-defined [123,124]. However, leporine nasal cartilage is significantly less cellular and has different shapes and thicknesses than human cartilage [125].…”

Section: 5: Validation Of Engineered Nasal Cartilagesmentioning

confidence: 99%

Toward tissue-engineering of nasal cartilages

et al. 2019

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Section: 5: Validation Of Engineered Nasal Cartilagesmentioning

confidence: 99%

Toward tissue-engineering of nasal cartilages

et al. 2019

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“… 17 It has been reported that when the basement membrane is intact after injury, the respiratory epithelium restores to its normal height after several days, but when the basement membrane is damaged, regeneration takes several weeks with the formation of squamous or transitional epithelium. 10 The subepithelial glands are not always regenerated, and the lamina propria may be substituted by dense connective tissue. 4 A circular wound created in rabbit sinus mucosa decreased in size concentrically with a speed of 20 μm/hour at the initial stage and decreased to 4–5 μm/hour after 7 days.…”

Section: Discussionmentioning

confidence: 99%

“… 4 A circular wound created in rabbit sinus mucosa decreased in size concentrically with a speed of 20 μm/hour at the initial stage and decreased to 4–5 μm/hour after 7 days. 10 However, the regeneration time of a septal mucosal defect, has not been reported in the literature so far.…”

Section: Discussionmentioning

confidence: 99%

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Healing of the nasal septal mucosa in an experimental rabbit model of mucosal injury

Choi

Cho

Choi

et al. 2017

World j. otorhinolaryngol.-head neck surg.

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ObjectiveThe aim of this study was to investigate the regeneration process of the nasal mucosa after a surgically created mucosal defect in the rabbit nasal septum, and to evaluate the effects of different interventions.MethodsA 7 mm-diameter circular mucosal defect was made in the septum of forty New Zealand white rabbits. The rabbits were divided into four groups (ten rabbits in each group) according to the type of intervention; no treatment (control), silastic sheet (SS), hyaluronic acid (HA), and silastic sheet and hyaluronic acid (SS + HA) group. The diameter of the defect, mucosal thickness, epithelial thickness, and ciliated cell count were evaluated every week for five weeks.ResultsThe average diameter of the defect in the control group were 5.1, 3.65, 1.2, 0.75, and 0.05 mm at postoperative 1, 2, 3, 4, and 5 weeks. In the SS group, the diameter decreased to 4.35, 2.1, 0.35, 0.15, and 0 mm at postoperative 1, 2, 3, 4, and 5 weeks, respectively, in which the mean diameter of the postoperative week 2 was significantly smaller compared to control (3.65 mm vs. 2.1 mm, P = 0.039). For the HA group and SS + HA group, the diameter of the defect did not show a significant difference from the control group during the five weeks. The mucosal thickness, epithelial thickness, and ciliated cell count of the regenerated mucosa were not significantly different among the groups.ConclusionThe regeneration process of the nasal septal mucosa was identified using a novel rabbit model. Mucosal regeneration can be accelerated by applying silastic sheets.

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“…A previously-proposed rabbit in vivo model may address some of these issues. 2 However, the prohibitive cost of live animal models would prevent that from becoming a widely applicable educational tool. On the other hand, isolating the cartilaginous framework of the nasal tip in our proposed model may in fact be advantageous for tip mechanics research.…”

Section: Discussionmentioning

confidence: 99%

Porcine Cartilage Model for Simulation of Nasal Tip Aesthetics and Mechanics

Chark

Oliaei

Manuel

et al. 2011

Aesthetic Surgery Journal

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Background The aesthetics of the human nose is highly dependent on the complex structure of the lower lateral cartilages (LLC). Understanding optimum shape and mechanical properties of the LLC is pivotal to achieving satisfactory results in nasal tip rhinoplasty. Objective The authors introduce an ex vivo animal model to replicate the shape and mechanics of human nasal LLC as a tool for research and surgical education. Methods Seven fresh pig heads were obtained from a local butcher shop. Nasal cartilage was harvested in a replicable manner and fashioned into appropriate shapes and dimensions based on the authors' human cadaver studies. Sutures were placed to approximate the cartilage pairs into appropriate human anatomical position. Results The porcine cartilage model replicated analogous structures, including the medial crura and the lateral crura, with appropriate cephalic orientation and domal angles. The anterior-posterior dimensions of the medial crura, intermediate crura, and lateral crura were 4 mm, 6 mm, and 10 mm, respectively. Cartilage thickness was approximately 1 mm throughout the specimen. Cephalic orientation of the lateral crura was sculpted to 45°. The average angle of divergence was 54° and varied according to the physiological shape of the porcine nasal vault (range, 43-74°). Average interdomal distance was 13.3 mm (range, 9-18 mm), and average domal width was 6.2 mm (range, 5-7 mm). Conclusions This novel porcine model mimics human LLC and is inexpensive, easy to construct, and highly replicable. This model can be used as a valuable educational resource for training novice surgeons in the principles of nasal tip rhinoplasty. Additionally, our construct has broad applications in studying LLC geometry and mechanics.

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Rhinoplasty Model in Rabbit

Cited by 21 publications

References 13 publications

Toward tissue-engineering of nasal cartilages

Toward tissue-engineering of nasal cartilages

Healing of the nasal septal mucosa in an experimental rabbit model of mucosal injury

Porcine Cartilage Model for Simulation of Nasal Tip Aesthetics and Mechanics

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