Rhinology in review: from COVID-19 to biologicals

Fokkens, Wytske J.; Landis, Basile Nicolas; Hopkins, Claire; Reitsma, Sietze; Sedaghat, Ahmad R.

doi:10.4193/rhin21.424

Cited by 4 publications

(2 citation statements)

References 184 publications

(168 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…

One of the otorhinolaryngological manifestations of the post-COVID-19 syndrome is rhinosinusitis [6]. The latter is known to be caused by various factors of exogenous and endogenous origin [7], but in patients in post-COVID-19 period, based on literature data, it is caused by fungi [8,9].

…”

mentioning

confidence: 99%

Rhinosinusitis in Patients in Post-Covid-19 Period: Etiology, Clinical and Morphological Characteristics

Myroshnychenko

Kalashnyk-Vakulenko

Kapustnyk³

et al. 2022

Wiad Lek

View full text Add to dashboard Cite

The aim is to identify the etiology, clinical and morphological features of rhinosinusitis in patients in post-COVID-19 period. Materials and methods: In the present study, it was carried out the analysis of 11 cases of rhinosinusitis, which developed after COVID-19 infection. The diagnosis of rhi¬nosinusitis was established on the basis of anamnesis, clinical and laboratory examination, specialized instrumental examination (rhinoendoscopy, X-ray, magnetic resonance imaging, spiral and 3D computed tomography). All patients underwent endoscopic sanitation of the nasal cavity, expansion of the maxillary anastomosis, maxillary sinusotomy, sanitation of the maxillary sinuses and removal of pathologically altered tissues. Microbiological examination of the swab from the nasal cavity was carried out in all patients. Histological and morphometric research methods were used during the morphological study of surgical material. The nonparametric Mann-Whitney U test was used to compare the means in the groups. Results: The conducted comprehensive study made it possible to identify chronic atrophic rhinosinusitis at the stage of exacerbation caused by associations of bacteria and fungi in patients in post-COVID-19 period. Among bacteria, the authors most often noted Staphylococcus aureus, Staphylococcus epidermidis, Klebsiella pneumonia, Streptococcus pneumonia and Enterococcus faecalis. Among fungi, there were Aspergillus, Candida, Mucor and Coccidioides. Fungal infection was characterized by invasion into the mucous membrane of the nose and paranasal sinuses. In patients in post-COVID-19 period the invasive bacterial-fungal chronic atrophic rhinosinusitis at the stage of exacerbation was predominantly bilateral, characterized by the involvement of several or all paranasal sinuses in the process. Patients with such pathology complained of periodic fever, headaches and malaise; nasal congestion and constant difficulty in nasal breathing; yellowish-greenish-reddish discharge from the nasal cavity, sometimes with a fetid odor; discomfort and pain in the area of paranasal sinuses; immobility of the eyeball, hyposmia or anosmia; reduction or complete loss of vision. Frequent risk factors for the development of invasive bacterial-fungal chronic atrophic rhinosinusitis at the stage of exacerbation in patients in post-COVID-19 period were the information about moderate or severe course of this infection in anamnesis; comorbidities (predominantly diabetes mellitus, hypertensive disease and ischemic heart disease). Conclusions: The study conducted by the authors made it possible to identify the etiological, clinical and morphological features, as well as risk factors of rhinosinusitis in patients in post-COVID-19 period. This information will contribute to a better understanding of such pathology by the doctors and improve the diagnostic and treatment process.

show abstract

“…

…”

mentioning

confidence: 99%

Rhinosinusitis in Patients in Post-Covid-19 Period: Etiology, Clinical and Morphological Characteristics

Myroshnychenko

Kalashnyk-Vakulenko

Kapustnyk³

et al. 2022

Wiad Lek

View full text Add to dashboard Cite

show abstract

“…Several reports indicate that elevated calcium cation levels in olfactory mucus have adverse effects on the olfactory mechanism. The shift in calcium cation concentration has physiological significance and correlates with the odor management process [ 13 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of intra-nasal nitrilotriacetic acid trisodium salt in lowering elevated calcium cations and improving olfactory dysfunction in COVID-19 patients

Abdelazim

Ismaiel

et al. 2022

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

Purpose An association between COVID-19 and olfactory dysfunction has been noted in many patients worldwide. The olfactory adaptation process leads to an increase in intracellular calcium cation levels. Nitrilotriacetic acid trisodium salt has high selective chelation for calcium cations from olfactory mucus. The aim of this work is to test the effect of an intranasal nitrilotriacetic acid trisodium salt to lower the elevated calcium cations in COVID-19 patients with relevant symptoms of olfactory dysfunction. Methods Fifty-eight COVID-19 adult patients with relevant symptoms of olfactory dysfunction were enrolled in a prospective randomized controlled trial. They received a nasal spray containing either 0.9% sodium chloride or 2% nitrilotriacetic acid trisodium salt. Olfactory function was assessed before and after treatment using the Sniffin’ Sticks test. Quantitative analysis of calcium cation concentration in nasal secretions was performed using a carbon paste ion-selective electrode. Results After the application of nitrilotriacetic acid trisodium salt compared to sodium chloride, a significant improvement from functional anosmia to healthy normosmia with significant decrease in calcium cation concentration was observed. Conclusions Further collaborative research is needed to fully investigate the effect of an intranasal nitrilotriacetic acid trisodium salt in the treatment of olfactory disorders.

show abstract

Efficacy of pentasodium diethylenetriamine pentaacetate in ameliorating anosmia post COVID-19

Imam

Abdelazim

et al. 2023

American Journal of Otolaryngology

View full text Add to dashboard Cite

Rhinology in review: from COVID-19 to biologicals

Cited by 4 publications

References 184 publications

Rhinosinusitis in Patients in Post-Covid-19 Period: Etiology, Clinical and Morphological Characteristics

Rhinosinusitis in Patients in Post-Covid-19 Period: Etiology, Clinical and Morphological Characteristics

Effect of intra-nasal nitrilotriacetic acid trisodium salt in lowering elevated calcium cations and improving olfactory dysfunction in COVID-19 patients

Efficacy of pentasodium diethylenetriamine pentaacetate in ameliorating anosmia post COVID-19

Contact Info

Product

Resources

About