Efficacy of pentasodium diethylenetriamine pentaacetate in ameliorating anosmia post COVID-19

Imam, Mohamed S.; Abdelazim, Mohamed H.; Abdelazim, Ahmed H.; Ismaiel, Wael F.; Mahmoud, Mohamed; Abourehab, Mohammed A.S.; Alghamdi, Saleh; Alghamdi, Mohamed A.; Ghoneim, Mohammed M.; Elwany, Samy

doi:10.1016/j.amjoto.2023.103871

Cited by 4 publications

(2 citation statements)

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“…Given the heterogeneity in the definition of long COVID and evidence indicating that it may comprise several distinct phenotypes (16), we anticipate that some interventions may be better suited for patients with certain phenotypes of long COVID. For example, pulmonary rehabilitation will likely only be effective for patients who are experiencing pulmonary sequelae related to COVID-19, (90), interventions targeting cognitive function will likely only be effective for patients experiencing neurocognitive sequelae related to COVID-19 (91), and interventions aimed at restoring sense of smell will only be effective for patients experiencing anosmia (92). Other interventions may be suitable for patients experiencing general symptoms related to long COVID, such as fatigue, post-exertional malaise, and headaches.…”

Section: Data Synthesis and Analysismentioning

confidence: 99%

Interventions for the management of post COVID-19 condition (long COVID): Protocol for a living systematic review & network meta-analysis

Zeraatkar,

Ling,

Kirsh

et al. 2024

Preprint

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Background Up to 15% of survivors of COVID-19 infection experience long-term health effects, including fatigue, myalgia, and impaired cognitive function, termed post COVID-19 condition or long COVID. Several trials that study the benefits and harms of various interventions to manage long COVID have been published and hundreds more are planned or are ongoing. Trustworthy systematic reviews that clarify the benefits and harms of interventions are critical to promote evidence-based practice. Objective To create and maintain a living systematic review and network meta-analysis addressing the benefits and harms of pharmacologic and non-pharmacologic interventions for the treatment and management of long COVID. Methods Eligible trials will randomize adults with long COVID, to pharmacologic or non-pharmacologic interventions, placebo, sham, or usual care. We will identify eligible studies by searches of MEDLINE, EMBASE, CINAHL, PsycInfo, AMED, and CENTRAL, from inception, without language restrictions. Reviewers will work independently and in duplicate to screen search records, collect data from eligible trials, including trial and patient characteristics and outcomes of interest, and assess risk of bias. Our outcomes of interest will include fatigue, pain, post-exertional malaise, changes in education or employment status, cognitive function, mental health, dyspnea, quality of life, patient-reported physical function, recovery, and serious adverse events. For each outcome, when possible, we will perform a frequentist random-effects network meta-analysis. When there are compelling reasons to suspect that certain interventions are only applicable or effective for a subtype of long COVID, we will perform separate network meta-analyses. The GRADE approach will guide our assessment of the certainty of evidence. We will update our living review biannually, upon the publication of a seminal trial, or when new evidence emerges that may change clinical practice. Conclusion This living systematic review and network meta-analysis will provide comprehensive, trustworthy, and up-to-date summaries of the evidence addressing the benefits and harms of interventions for the treatment and management of long COVID. We will make our findings available publicly and work with guideline producing organizations to inform their recommendations.

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Section: Data Synthesis and Analysismentioning

confidence: 99%

Interventions for the management of post COVID-19 condition (long COVID): Protocol for a living systematic review & network meta-analysis

Zeraatkar,

Ling,

Kirsh

et al. 2024

Preprint

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“…olfativos em 30 dias, iniciando o quadro de melhora em até 13 dias, mas não houve diferença entre os grupos quando comparado o tempo de recuperação(RASHID et al, 2021).Os corticosteróides podem ter efeitos anti inflamatórios benéficos a curto prazo, reduzindo o processo inflamatório local, principalmente com o uso dos esteróides tópicos 649 ANAIS DO IV CONGRESSO NORTE-NORDESTE DE SAÚDE PÚBLICA (ON-LINE) "A SAÚDE É PARA TODOS" -RESUMOS EXPANDIDOS e intranasais (Além disso, quanto mais precoce for iniciada a terapia nos pacientes melhor o resultado. Outras vantagens do treinamento olfativo estão relacionadas ao seu baixo custo e ausência de efeitos colaterais (KHAN et al, 2022; SCHMIDT, AZAR e GOEKTAS, 2023).tendo resultados positivos com a melhora total ou parcial da anosmia(ABDELAZIM et al, 2022;ABDELAZIM, ABDELAZIM e MONEIR, 2022;IMAM et al, 2023).…”

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Anais Do Iv Congresso Norte-Nordeste De Saúde Pública (On-Line) “A Saúde É Para Todos” – Resumos Expandidos

2023

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melhor a importância do bombeiro na saúde e também durante a parte prática, em que foi ensinado sobre como realizar os primeiros socorros em casos de encontrar indivíduos engasgados, convulsionando e/ou desmaiados. CONCLUSÃODestaca-se que a realização do evento, em especial ao terceiro dia, em que foi realizada apresentações e práticas referentes ao atendimento pré hospitalar contemplou uma metodologia de ensino fora dos padrões tradicionais de ensino, também incentivou e dispertou ainda mais o ânimo e curiosidade dos alunos na temática. Além disso, contar com a presença de profissionais dispostos a compartilhar experiências e conhecimentos é de grande valia para manter a qualidade da educação de futuros profissionais de enfermagem. REFERÊNCIASMACHADO, Neiva Claudete Brondani. et.al., Percepção de discentes, docentes e técnicos em enfermagem a respeito dos eventos adversos. Revista De Enfermagem Da UFSM, 2020. Disponível em: https://periodicos.ufsm.br/reufsm/article/view/33486 SILVA, Natália Chantal Magalhães da Silva. et al., Estratégias de ensino das terapias alternativas e complementares na graduação em Enfermagem: revisão integrativa.

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Local budesonide therapy in the management of persistent hyposmia in suspected non-severe COVID-19 patients: Results of a randomized controlled trial

Hautefort,

Corré,

Poillon

et al. 2023

International Journal of Infectious Diseases

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Efficacy of pentasodium diethylenetriamine pentaacetate in ameliorating anosmia post COVID-19

Cited by 4 publications

References 14 publications

Interventions for the management of post COVID-19 condition (long COVID): Protocol for a living systematic review & network meta-analysis

Interventions for the management of post COVID-19 condition (long COVID): Protocol for a living systematic review & network meta-analysis

Anais Do Iv Congresso Norte-Nordeste De Saúde Pública (On-Line) “A Saúde É Para Todos” – Resumos Expandidos

Local budesonide therapy in the management of persistent hyposmia in suspected non-severe COVID-19 patients: Results of a randomized controlled trial

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