Rheopexy of synovial fluid and protein aggregation

Oates, Katherine M. N.; Krause, Wendy E.; Jones, Ronald L.; Colby, Ralph H.

doi:10.1098/rsif.2005.0086

Cited by 113 publications

(150 citation statements)

References 89 publications

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“…These facts suggest the synergistic effect of -globulin and HA, but indicate the adverse interaction of albumin and HA for intact cartilage. It is reported that albumin and HA show repulsive interaction [36] and the HA-protein complexes in natural synovial fluid contain globulin but almost no albumin at pH 7-8 [37]. These frictional trends for both proteins are similar for damaged cartilage with partially removed surface proteoglycan gel layer.…”

Section: Discussionmentioning

confidence: 48%

“…The lubricant No.13 has similar composition to that in natural synovial fluid as hyaluronate solution containing lubricating constituents such as 1.25 wt% albumin, 0.75 wt% globulin (including --, and -globulins) as medium values [42], 1.1 wt% albumin and 0.7 wt% globulin [36], or 1.9 wt% albumin, 1.1 wt% globulin and 0.01 wt% DPPC [12]. In this lubricant, the lubricating layered structure in adsorbed film is expected for low friction and minimal wear, but the detailed elucidation of this mechanism is required in the future study.…”

Section: Discussionmentioning

confidence: 99%

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Influence of synovia constituents on tribological behaviors of articular cartilage

et al. 2013

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Abstract:The extremely low friction and minimal wear in natural synovial joints appear to be established by effective lubrication mechanisms based on appropriate combination of articular cartilage and synovial fluid. The complex structure of cartilage composed of collagen and proteoglycan with high water content contributes to high load-carrying capacity as biphasic materials and the various constituents of synovial fluid play important roles in various lubrication mechanisms. However, the detailed differences in functions of the intact and damaged cartilage tissues, and the interaction or synergistic action of synovia constituents with articular cartilage have not yet been clarified. In this study, to examine the roles of synovia constituents and the importance of cartilage surface conditions, the changes in friction were observed in the reciprocating tests of intact and damaged articular cartilage specimens against glass plate lubricated with lubricants containing phospholipid, protein and/or hyaluronic acid as main constituents in synovial fluid. The effectiveness of lubricant constituents and the influence of cartilage surface conditions on friction are discussed. In addition, the protectiveness by synovia constituents for intact articular cartilage surfaces is evaluated.

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Section: Discussionmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 99%

Influence of synovia constituents on tribological behaviors of articular cartilage

et al. 2013

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“…But the actual use and processing of food products, physiological fluids like blood 62 , saliva 23 , synovial fluid and their synthetic replacements 19 , cosmetics 47,63 , etc. requires an understanding of both their bulk and interfacial viscoelasticity.…”

Section: Discussionmentioning

confidence: 99%

“…When the rheological properties of globular protein solutions such as BSA are tested in a torsional rheometer, they exhibit yield-like behaviour at surprisingly low concentrations (0.03%-10%) [15][16][17][18][19][20] , and show pronounced shear thinning at low shear rates. This has been attributed in past studies [15][16][17] to the presence of long ranging colloidal forces that are stronger than electrostatic interactions, and which lead to an ordered bulk colloidal structure formation.…”

Section: Introductionmentioning

confidence: 99%

Interfacial viscoelasticity, yielding and creep ringing of globular protein–surfactant mixtures

2011

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Protein-surfactant mixtures arise in many industrial and biological systems, and indeed, blood itself is a mixture of serum albumins along with various other surface-active components. Bovine serum albumin (BSA) solutions, and globular proteins in general, exhibit an apparent yield stress in bulk rheological measurements at surprisingly low concentrations. By contrasting interfacial rheological measurements with corresponding interface-free data obtained using a microfluidic rheometer, we show that the apparent yield stress exhibited by these solutions arises from the presence of a viscoelastic layer formed due to the adsorption of protein molecules at the air-water interface. The coupling between instrument inertia and surface elasticity in a controlled stress device also results in a distinctive damped oscillatory strain response during creep experiments known as"creep ringing". We show that this response can be exploited to extract the interfacial storage and loss moduli of the protein interface. The interfacial creep response at small strains can be described by a simple second order system, such as the linear Jeffreys model, however the interfacial response rapidly becomes nonlinear beyond strains of order 1%. We use the two complementary techniques of interfacial rheometry and microfluidic rheometry to examine the systematic changes in the surface and bulk material functions for mixtures of a common non-ionic surfactant, Polysorbate 80, and BSA. It is observed that the nonlinear viscoelastic properties of the interface are significantly suppressed by the presence of even a relatively small amount of surfactant (c surf > 10 −3 wt.%).

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“…This fluid is a complex mixture of macromolecules with a large concentration of plasma proteins which demonstrates non-Newtonian behaviour [4,5]. The properties of the fluid, including pH and protein content vary from patient to patient, and between healthy and diseased states [6,7].…”

Section: Introductionmentioning

confidence: 99%

Synovial Fluid Lubrication: The Effect of Protein Interactions on Adsorbed and Lubricating Films

et al. 2015

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Rheopexy of synovial fluid and protein aggregation

Cited by 113 publications

References 89 publications

Influence of synovia constituents on tribological behaviors of articular cartilage

Influence of synovia constituents on tribological behaviors of articular cartilage

Interfacial viscoelasticity, yielding and creep ringing of globular protein–surfactant mixtures

Synovial Fluid Lubrication: The Effect of Protein Interactions on Adsorbed and Lubricating Films

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