Rhaphiodon echinus (Nees &amp; Mart.) Schauer: Chemical, toxicological activity and increased antibiotic activity of antifungal drug activity and antibacterial

Costa, Adrielle Rodrigues; Silva, Juliana de Lima; Lima, Kátia Regina Rodrigues; Rocha, Maria Ivaneide; Barros, Luiz Marivando; Costa, José Galberto Martins da; Boligon, Aline Augusti; Carneiro, Joara Nályda Pereira; Leite, Nádghia Figueiredo; Menezes, Irwin Rose Alencar de; Duarte, Antônia Eliene; Morais-Braga, Maria Flaviana Bezerra; Coutinho, Henrique Douglas Melo

doi:10.1016/j.micpath.2017.04.001

Cited by 16 publications

(15 citation statements)

References 18 publications

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“…Interestingly, Costa et al (2017) evaluated the capacity of aqueous and ethanolic extracts from Rhaphiodon echinus (Nees & Mart.) Schauer.…”

Section: Biological Investigationsmentioning

confidence: 99%

“…Still addressing leveduriform fungal species, Costa et al (2017) demonstrated that the association of the aqueous or ethanolic extracts of Rhaphiodon echinus with the antifungal drug nystatin causes an antagonic effect in the drug activity against Candida albicans and Candida tropicalis. Indeed, this combination (using aqueous extract) provoked a reduction in the MIC of nystatin against Candida krusei .…”

Section: Biological Investigationsmentioning

confidence: 99%

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Subtribe Hyptidinae (Lamiaceae): A promising source of bioactive metabolites

Bridi

Meirelles

Poser

2021

Journal of Ethnopharmacology

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Ethnopharmacological relevance The subtribe Hyptidinae contains approximately 400 accepted species distributed in 19 genera ( Hyptis , Eriope , Condea , Cantinoa , Mesosphaerum , Cyanocephalus , Hypenia , Hyptidendron , Oocephalus , Medusantha , Gymneia , Marsypianthes , Leptohyptis , Martianthus , Asterohyptis , Eplingiella , Physominthe , Eriopidion and Rhaphiodon ). This is the Lamiaceae clade with the largest number of species in Brazil and high rates of endemism. Some species have been used in different parts of the world mainly as insecticides/pest repellents, wound healing and pain-relief agents, as well as for the treatment of respiratory and gastrointestinal disorders. Aim of the review This review aims to discuss the current status concerning the taxonomy, ethnobotanical uses, phytochemistry and biological properties of species which compose the subtribe Hyptidinae. Materials and methods The available information was collected from scientific databases (ScienceDirect, Pubmed, Web of Science, Scopus, Google Scholar, ChemSpider, SciFinder ACS Publications, Wiley Online Library), as well as other literature sources (e.g. books, theses). Results The phytochemical investigations of plants of this subtribe have led to the identification of almost 300 chemical constituents of different classes such as diterpenes, triterpenes, lignans, α -pyrones, flavonoids, phenolic acids and monoterpenes and sesquiterpenes, as components of essential oils. Extracts, essential oils and isolated compounds showed a series of biological activities such as insecticide/repellent, antimicrobial and antinociceptive, justifying some of the popular uses of the plants. In addition, a very relevant fact is that several species produce podophyllotoxin and related lignans. Conclusion Several species of Hyptidinae are used in folk medicine for treating many diseases but only a small fraction of the species has been explored and most of the traditional uses have not been validated by current investigations. In addition, the species of the subtribe appear to be very promising as alternative sources of podophyllotoxin-like lignans which are the lead compounds for the semi-synthesis of teniposide and etoposide, important antineoplastic agents. Thus, there is a wide-open door for future studies, both to support the popular uses of the plants and to find new biologically active compoun...

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“…Interestingly, Costa et al (2017) evaluated the capacity of aqueous and ethanolic extracts from Rhaphiodon echinus (Nees & Mart.) Schauer.…”

Section: Biological Investigationsmentioning

confidence: 99%

Section: Biological Investigationsmentioning

confidence: 99%

Subtribe Hyptidinae (Lamiaceae): A promising source of bioactive metabolites

Bridi

Meirelles

Poser

2021

Journal of Ethnopharmacology

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“…Usually they are mainly composed of mono and sesquiterpenes, however it is common to find other types of terpenes such as diterpenes (Bezerra et al, 2018). Among the biological activities, the main ones are antimicrobial, larvicidal, allelopathic and insecticidal actions (Costa et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Insecticide Activity of Essential Oil of Mesosphaerum suaveolens Against Nauphoeta cinerea

Bezerra

Neto²,

Filho³

et al. 2020

JAS

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Essential oils are compounds produced by secondary plant metabolites and are found in leaf trichomes, moreover, they are characteristic because they present strong odors and present biological activities. Thus, the objective of this work was to evaluate the insecticidal action of Mesosphaerum suaveolens essential oil against nymphs of Nauphoeta cinerea as well as to characterize the chemical constituents present in it. The EO was extracted by means of hydrodistillation and its chemical characterization was done by Gas Chromatography coupled to Mass Spectrometry (GC/MS). For the biological assay against cockroaches, nymphs of 20 days old were selected for which they were submitted to different concentrations (50 - 1000 μg/mL oil per air) and mortality was evaluated over 48 hours of EO exposure. As a positive control, ethanol (C2H6O) was used. Have been identified 44 compounds in EO, with β-Caryophyllene (18.57%), sabinene (15.94%) and spatulenol (11.09%) being the major compounds of EO. This showed no activity against the nymphs at any of the concentrations, whereas the positive control caused mortality at all concentrations tested. Thus, the essential oil of M. suaveolens does not present insecticidal properties in low concentrations against the cockroach.

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“…When an imbalance between the microbiota and the host's immune system occurs, these fungi can become pathogenic, causing candidiasis and presenting different clinical forms depending on the type of infection and the degree of immunosuppression. Nevertheless, mucosal, systemic, and allergic skin reactions are the common clinical presentation [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

In vitro Antibiotic and Modulatory Activity of Mesosphaerum suaveolens (L.) Kuntze against Candida strains

et al. 2020

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The emergence of fungal resistance to commercial drugs has been a major problem for the WHO. In this context, research with natural products is promising in the discovery of new active substances. Thus, this work evaluated the antifungal effect of a medicinal plant (i.e., Mesosphaerum suaveolens) against strains of the genus Candida, tested the combined effect with the drug fluconazole, and, finally, determined the phenolic constituents present in the species. Initially, aqueous extracts of leaves (AELMs) and aerial parts (AEAPMs) of the species were prepared. For microbiological assays, the minimum fungicidal concentration was determined by broth microdilution, and the combined effect of fluconazole extracts were verified by sub-inhibitory microdilution concentrations (CFM/8) followed by spectrophotometric readings which were used to determine the IC50. HPLC detected the presence of flavonoids and phenolic acids, detecting eight compounds present in the samples of which caffeic acid and quercetin were major components. The AELMs modulated fluconazole activity since it decreased fluconazole’s IC50 from 7.8 µg/mL to an IC50 of 4.7 µg/mL (CA LM 77) and from 28.8 µg/mL to 18.26 µg/mL (CA INCQS 40006) for the C. albicans strains. The AEAPMs were able to potentiate the effect of fluconazole more effectively than the AELMs. Such an effect was significant for the 16 µg/mL concentration for CA LM 77 and 32 µg/mL for CA INCQS 40006. The AEAPMs as well as the AELMs presented clinically relevant activities for C. tropicalis strains. For the C. tropicalis LM 23 strain, the AEPMs obtained an IC50 of 25 µg/mL and the AELMs an IC50 of 359.9 µg/mL.

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Rhaphiodon echinus (Nees & Mart.) Schauer: Chemical, toxicological activity and increased antibiotic activity of antifungal drug activity and antibacterial

Cited by 16 publications

References 18 publications

Subtribe Hyptidinae (Lamiaceae): A promising source of bioactive metabolites

Subtribe Hyptidinae (Lamiaceae): A promising source of bioactive metabolites

Chemical Composition and Insecticide Activity of Essential Oil of Mesosphaerum suaveolens Against Nauphoeta cinerea

In vitro Antibiotic and Modulatory Activity of Mesosphaerum suaveolens (L.) Kuntze against Candida strains

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