RGO@Cu₂O@Cu Ternary Nanocomposite for High-Performance Non-Enzymatic Glucose Detection

Abstract

Fast, reliable, and low-cost glucose detection methods are of great importance for the control of diabetes. In this study, Cu2O combined with Cu nanoparticles anchored on reduced graphene oxide (RGO), was synthesized to function as the electrode in a non-enzymatic glucose sensor. The synergistic effect between Cu nanoparticles and Cu2O, together with the high conductivity of RGO enabled considerably lower resistivity with greater glucose oxidation activity than pure Cu2O. The RGO@Cu2O@Cu electrode exhibited a high sensitivity of 1.112 mA mM−1 cm−2 with a detection limit of 0.019 μM, and the linear range is up to 4 mM. Additionally, the RGO@Cu2O@Cu electrode displayed good anti-interference performance within human blood and high stability while operating for a long duration. Significantly, the glucose detection capability of the as-designed electrode was comparable to commercial sensors, representing a valuable design for future non-enzymatic glucose sensing.

Free-standing hybrid material of Cu/Cu2O/CuO modified by graphene with commercial Cu foil using for non-enzymatic glucose detection

“…In 2017, grapheme, Cu 2 O and CuO have been decorated simultaneously on Cu foam for glucose detection [19]. The synergistic effect between the Cu 0 , Cu +1 and Cu +2 is declared to have great favor in improving the sensing property and the incorporation of the graphene is found improved the electron transfer velocity and thus further improved the property of the sensors [20,21]. As a result, compounds of graphene with Cu, Cu 2 O and CuO have been successfully prepared with hydrothermal method [22].…”

A catalyst support for direct-ammonia solid-oxide fuel cell anodes based on lanthanum titanium oxynitride

“…43 The presence of metallic Cu was conrmed with the peak positioned at a lower binding energy of 564.60 eV, a value similar to previous reports. [44][45][46] The ratio between Cu and Cu 2 O on the surface was found to be 5 : 1, thereby conrming that the surface copper formed is largely metallic.…”

Wearable Noninvasive Glucose Sensor Based on CuxO NFs/Cu NPs Nanocomposites

“…Cu(II) oxide and Cu(I) oxide are widely known copper oxides that have outstanding sensing capacities. An electron pair reaction involving the redox couple ions Cu(III) and Cu(II) formed the foundation for the sensing mechanism [ 24 , 25 ]. The continuous transformation of electrons was available by the redox pair ions, which serve as an intermediary mediator [ 26 , 27 , 28 , 29 ].…”