RGD Peptide as a Targeting Moiety for Theranostic Purpose: An Update Study

Asati, Saket; Pandey, Vikas; Soni, Vandana

doi:10.1007/s10989-018-9728-3

Cited by 47 publications

(32 citation statements)

References 140 publications

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“…The most well-known and widely utilized peptide targeting group is the RGD (Arg-Gly-Asp) motif. This tripeptide tag binds to integrins, and is therefore frequently used to target cancer cells [223][224][225]; however, this has also been applied to antimicrobial silver nanoparticles [226]. Chitin binding peptides have been shown to target fungal cell walls [227].…”

Section: Active Targetingmentioning

confidence: 99%

Supramolecular Peptide Assemblies as Antimicrobial Scaffolds

2020

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Antimicrobial discovery in the age of antibiotic resistance has demanded the prioritization of non-conventional therapies that act on new targets or employ novel mechanisms. Among these, supramolecular antimicrobial peptide assemblies have emerged as attractive therapeutic platforms, operating as both the bactericidal agent and delivery vector for combinatorial antibiotics. Leveraging their programmable inter- and intra-molecular interactions, peptides can be engineered to form higher ordered monolithic or co-assembled structures, including nano-fibers, -nets, and -tubes, where their unique bifunctionalities often emerge from the supramolecular state. Further advancements have included the formation of macroscopic hydrogels that act as bioresponsive, bactericidal materials. This systematic review covers recent advances in the development of supramolecular antimicrobial peptide technologies and discusses their potential impact on future drug discovery efforts.

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Section: Active Targetingmentioning

confidence: 99%

Supramolecular Peptide Assemblies as Antimicrobial Scaffolds

2020

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“…Lesions, such as tumor sites, show different characters in comparison with other healthy tissues. 6 Targeting peptides are in various kinds and mainly discovered by peptide library screening technologies. This screening process ensures the high affinity and targeting capability.…”

Section: Targeting Peptidesmentioning

confidence: 99%

Recent advances on peptide‐based theranostic nanomaterials

Rong

Lei

Zhang

2020

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Theranostic nanomaterial, which amalgamates diagnosis and therapy of diseases into one nanosystem, has become one of the core interests in nanomedicine research. Functional peptides can be integrated into theranostic nanomaterials and endow them with special properties to accomplish much more complicated biomedical tasks. Peptide-based theranostic nanomaterials can be formulated with specific targeting, transmembrane delivery, and stimulus response. In this Minireview, we describe general ideas of fabricating peptide-based theranostic nanomaterials, concerning the design and variegated biomedical applications, and highlighting their advances during the past 5 years.

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“…In this regard, various types of molecules, such as monoclonal antibodies or peptides, have been employed as highly specific molecular targeting moieties for the treatment of different types of cancer. Peptide‐based targeting delivery systems exhibit several advantages compared with antibodies: lower molecular weight, resulting in a better tissue‐penetrating capacity, a wider range of targets, low immunogenicity and higher affinity (4). Of specific interest are the RGD peptides, which specifically attach to α v β 3 integrin with a high binding affinity (5).…”

Section: Introductionmentioning

confidence: 99%

c(RGDfK)‐ and ZnTriMPyP‐Bound Polymeric Nanocarriers for Tumor‐Targeted Photodynamic Therapy

Heras

Boix-Garriga

Bryden

et al. 2020

Photochem & Photobiology

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Active targeting strategies are currently being extensively investigated in order to enhance the selectivity of photodynamic therapy. The aim of the present research was to evaluate whether the external decoration of nanopolymeric carriers with targeting peptides could add more value to a photosensitizer formulation and increase antitumor therapeutic efficacy and selectivity. To this end, we assessed PLGA‐PLA‐PEG nanoparticles (NPs) covalently attached to a hydrophilic photosensitizer 5‐[4‐azidophenyl]‐10,15,20‐tri‐(N‐methyl‐4‐pyridinium)porphyrinato zinc (II) trichloride (ZnTriMPyP) and also to c(RGDfK) peptides, in order to target αvβ3 integrin‐expressing cells. In vitro phototoxicity investigations showed that the ZnTriMPyP‐PLGA‐PLA‐PEG‐c(RGDfK) nanosystem is effective at submicromolar concentrations, is devoid of dark toxicity, successfully targets αvβ3 integrin‐expressing cells and is 10‐fold more potent than related nanosystems where the PS is occluded instead of covalently bound.

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RGD Peptide as a Targeting Moiety for Theranostic Purpose: An Update Study

Cited by 47 publications

References 140 publications

Supramolecular Peptide Assemblies as Antimicrobial Scaffolds

Supramolecular Peptide Assemblies as Antimicrobial Scaffolds

Recent advances on peptide‐based theranostic nanomaterials

c(RGDfK)‐ and ZnTriMPyP‐Bound Polymeric Nanocarriers for Tumor‐Targeted Photodynamic Therapy

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