Recent advances on peptide‐based theranostic nanomaterials

Rong, Lei; Lei, Qi; Zhang, Xian‐Zheng

doi:10.1002/viw.20200050

Cited by 27 publications

(17 citation statements)

References 55 publications

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“…Selective target, trans-membrane distribution, transport, and stimulation responsiveness could all be integrated within peptide-based theranostic nanostructures [ 74 ]. Throughout the article, the researchers had discussed generalized principles for synthesising peptide-based therapeutic, and diagnostic nano-materials, with a focus on performance, design, and numerous bio-medical possibilities, and they have illustrated their significant development over the last five years [ 74 ].…”

Section: Resultsmentioning

confidence: 99%

Comparative Analysis of Erosive Wear Behaviour of Epoxy, Polyester and Vinyl Esters Based Thermosetting Polymer Composites for Human Prosthetic Applications Using Taguchi Design

Khare¹,

Dahiya²,

Gangil

et al. 2021

Polymers

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In polymer composites, synthetic fibers are primarily used as a chief reinforcing material, with a wide range of applications, and are therefore essential to study. In the present work, we carried out the erosive wear of natural and synthetic fiber-based polymer composites. Glass fiber with jute and Grewia optiva fiber was reinforced in three different polymer resins: epoxy, vinyl ester and polyester. The hand lay-up method was used for the fabrication of composites. L16 orthogonal array of Taguchi method used to identify the most significant parameters (impact velocity, fiber content, and impingement angle) in the analysis of erosive wear. ANOVA analysis revealed that the most influential parameter was in the erosive wear analysis was impact velocity followed by fiber content and impingement angle. It was also observed that polyester-based composites exhibited the highest erosive wear followed by vinyl ester-based composites, and epoxy-based composites showed the lowest erosive wear. From the present study, it may be attributed that the low hardness of the polyester resulting in low resistance against the impact of erodent particles. The SEM analysis furthermore illustrates the mechanism took place during the wear examination of all three types of composites at highest fiber loading. A thorough assessment uncovers brittle fractures in certain regions, implying that a marginal amount of impact forces was also acting on the fabricated samples. The developed fiber-reinforced polymer sandwich composite materials possess excellent biocompatibility, desirable promising properties for prosthetic, orthopaedic, and bone-fracture implant uses.

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Section: Resultsmentioning

confidence: 99%

Comparative Analysis of Erosive Wear Behaviour of Epoxy, Polyester and Vinyl Esters Based Thermosetting Polymer Composites for Human Prosthetic Applications Using Taguchi Design

Khare¹,

Dahiya²,

Gangil

et al. 2021

Polymers

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show abstract

“…[ 203 ] Besides, the peptide functionalized carbon materials also possess the capability for accomplishing the diagnostic and therapeutic functions. [ 204,205 ] In future, extensive efforts will be put into the design strategy adapted for biosensing, in order to fully promote the performance and explore the potential of biomass‐derived carbon.…”

Section: The Application Of Sustainable Carbon Materials In Catalysismentioning

confidence: 99%

Sustainable Carbon Materials toward Emerging Applications

Lan

Yang

et al. 2021

Small Methods

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It is desirable for a sustainable society that the production and utilization of renewable materials are net‐zero in terms of carbon emissions. Carbon materials with emerging applications in CO2 utilization, renewable energy storage and conversion, and biomedicine have attracted much attention both academically and industrially. However, the preparation process of some new carbon materials suffers from energy consumption and environmental pollution issues. Therefore, the development of low‐cost, scalable, industrially and economically attractive, sustainable carbon material preparation methods are required. In this regard, the use of biomass and its derivatives as a precursor of carbon materials is a major feature of sustainability. Recent advances in the synthetic strategy of sustainable carbon materials and their emerging applications are summarized in this short review. Emphasis is made on the discussion of the original intentions and various sustainable strategies for producing sustainable carbon materials. This review provides basic insights and significant guidelines for the further design of sustainable carbon materials and their emerging applications in catalysis and the biomedical field.

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“…Although peptides and peptide-based vaccines and nanomaterials have been frequently reported for cancer therapy (Chiangjong et al, 2020;Malonis et al, 2020;Rong et al, 2020;Fan et al, 2021), the self-assembled peptidenanomaterials especially those targeting mitochondria as anticancer reagents are still in the primary stage. Currently, approaches of these nanomaterials for cancer therapy mainly include the delivery of anticancer drugs, destructions of mitochondria by mitochondria-cytotoxic peptides or peptideassemblies, and the combination with chemotherapy or photothermal therapy (PTT) (Supplementary Table S2).…”

Section: Applications In Cancer Therapymentioning

confidence: 99%

Mitochondria-Targeted Self-Assembly of Peptide-Based Nanomaterials

Luo

Gao

Duan

et al. 2021

Front. Bioeng. Biotechnol.

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Mitochondria are well known to serve as the powerhouse for cells and also the initiator for some vital signaling pathways. A variety of diseases are discovered to be associated with the abnormalities of mitochondria, including cancers. Thus, targeting mitochondria and their metabolisms are recognized to be promising for cancer therapy. In recent years, great efforts have been devoted to developing mitochondria-targeted pharmaceuticals, including small molecular drugs, peptides, proteins, and genes, with several molecular drugs and peptides enrolled in clinical trials. Along with the advances of nanotechnology, self-assembled peptide-nanomaterials that integrate the biomarker-targeting, stimuli-response, self-assembly, and therapeutic effect, have been attracted increasing interest in the fields of biotechnology and nanomedicine. Particularly, in situ mitochondria-targeted self-assembling peptides that can assemble on the surface or inside mitochondria have opened another dimension for the mitochondria-targeted cancer therapy. Here, we highlight the recent progress of mitochondria-targeted peptide-nanomaterials, especially those in situ self-assembly systems in mitochondria, and their applications in cancer treatments.

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Recent advances on peptide‐based theranostic nanomaterials

Cited by 27 publications

References 55 publications

Comparative Analysis of Erosive Wear Behaviour of Epoxy, Polyester and Vinyl Esters Based Thermosetting Polymer Composites for Human Prosthetic Applications Using Taguchi Design

Comparative Analysis of Erosive Wear Behaviour of Epoxy, Polyester and Vinyl Esters Based Thermosetting Polymer Composites for Human Prosthetic Applications Using Taguchi Design

Sustainable Carbon Materials toward Emerging Applications

Mitochondria-Targeted Self-Assembly of Peptide-Based Nanomaterials

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