Review on Some Malaysian Traditional Medicinal Plants with Therapeutic Properties

Alsarhan, Ali; Sultana, Naznin; Alkhatib, Ahed J; Kadir, Mohammed Rafiq Abdul

doi:10.6000/1927-5129.2014.10.20

Cited by 34 publications

(15 citation statements)

References 75 publications

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“…Polyherbal formulations are widely utilized in developed countries in contrast to allopathic medicines for the treatment of various forms of disorder [59]. Now a days, the herbal products symbolize safety compared to the synthetic allopathic drugs that present fatal adverse effects [60].…”

Section: Discussionmentioning

confidence: 99%

An exploratory analysis on the toxicity & safety profile of Polyherbal combination of curcumin, quercetin and rutin

et al. 2020

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Background Curcumin, quercetin and rutin are flavonoids having strong antioxidant potential, individually used in treatment of numerous ailments. The safety assessment of each of them is already established but no toxicological assessment has been done that would guarantee the safe use of these three flavonoids when used as a polyherbal combination (PHC). The aim of this study to evaluate the possible toxicological effect of polyherbal combination of these three flavonoids in female Swiss albino mice. Methods In acute toxicity study, the oral dose of poly herbal combination was administered to four groups stepwise in single dose and general behaviour, adverse effects and mortality were determined up to 14 days and compared to normal group. In sub-acute study, the tested poly herbal combination was administered orally for 28 days to the four experimental groups and their body weight was measured each alternate day from the first day of dosing. On 29th day the final body weight was recorded and euthanized by using thiopentone sodium, blood was collected and later haematological, lipid profile, biochemical parameter was evaluated and compared to normal group. Result In acute toxicity study, no abnormal general behaviour, adverse effects were reported. No significant changes were reported in body weight, haematological, lipid profile, biochemical parameter in sub-acute toxicity study. No mortality was reported in both the study. Histopathological examination revealed no alterations in clinical signs or organ weight at any dose. Conclusion The result concludes that the oral administration of Polyherbal combination did not produce any significant toxic effect in swiss albino mice. Hence, the Polyherbal combination can be utilized safely for therapeutic use.

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Section: Discussionmentioning

confidence: 99%

An exploratory analysis on the toxicity & safety profile of Polyherbal combination of curcumin, quercetin and rutin

et al. 2020

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“…Medicinal plants have been gaining attention because of the medicinal and nutritional benefits provided by their potential natural properties in amelioration numerous diseases. Important medicinal plants used in Malaysian traditional and modern medicine include Zingiber officinale, Coleus aromaticus, Citrus grandis L. Osbeck, Amaranthus spinosus L. and C. caudatus [3,4].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial, Antioxidant and Cytotoxic Activities of Cosmos Caudatus extracts

Sia¹,

Chern²,

Hii³

et al. 2021

IJETS

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This study aims to investigate the in-vitro antimicrobial potential of Cosmos caudatus against pathogenic bacteria, its antioxidant activity and cytotoxic effect on cancer cell lines. In vitro antimicrobial activities of ethanol and water extracts of Cosmos caudatus herb against pathogenic bacteria, Staphylococcus aureus, Salmonella sp., Pseudomonas aeruginosa and Escherichia coli were tested by agar well diffusion. Antioxidant properties of the extracts was evaluated by 2,2-diphenyl-1-picryl-hydrazyl radical scavenging activity method. Additionally, cytotoxic activity of the extracts on HCT 116 colorectal carcinoma cell line was determined by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Vero cells were used as a control. The quantification of these extracts showed that this plant is rich in secondary metabolites. Moreover, the conventional soxhlet extraction technique was more effective than maceration and ultrasonic assisted extraction technique. In antioxidants assay, both the ethanolic and water extracts through ultrasonic extraction method exhibited the highest DPPH free radical scavenging capacity compared to maceration and sohxlet extraction method. In antimicrobial assay, both the water and ethanol extracts showed no inhibitory action against the tested pathogenic bacteria. For anticancer activity, the F2, F7 and F8 fractions showed potent dose dependent cytotoxicity on Human Colorectal Carcinoma Cells with IC50 value of 15.53 ± 0.4, 32.72 ± 0.3 and 34.16 ± 1.4 μg/mL, respectively.

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“…Belongs to the family of Clusiaceae, it can be found in Malaysia, Myanmar, India and is widely cultivated in Sumatera Island as one of export commodity purposes (MyBIS, n.d;Bayu et al 2018). Other than being used in cooking as flavouring agent to replace tamarind, G. atroviridis is also being used traditionally in many ways to promote human health (Sultana et al 2014). The plant parts has been used by the old folks as an abdominal reliever during pregnancy, cough and throat irritation remedy, to combat dandruff problem and can enhance better blood circulation in body (Taher et al 2017).…”

Section: Introductionmentioning

confidence: 99%

“…The plant parts has been used by the old folks as an abdominal reliever during pregnancy, cough and throat irritation remedy, to combat dandruff problem and can enhance better blood circulation in body (Taher et al 2017). Based on Sultana et al (2014); Taher et al (2017); Bayu et al (2018), the fruit of this plant contains many organic compounds but the most interesting is the hydroxycitric acid. This acid has been commercialized under weight management product.…”

Section: Introductionmentioning

confidence: 99%

Antagonistic Activity of Fungal Endophytes Isolated from Garcinia atroviridis against Colletotrichum gloeosporioides

2020

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The extensive use of synthetic fungicides in controlling plant disease generates detrimental impacts on the environment and human health. In response to this problem, an alternative method was developed, known as biological control using antagonistic microorganisms. Since investigation on fungal endophytes of Garcinia atroviridis is still unclear, it was chosen for the study. The aim of the present work was to evaluate biocontrol potential of endophytic fungi against Colletotrichum gloeosporiodes, a phytopathogen that caused anthracnose disease. A total of 92 endophytic fungi were isolated from different tissue parts of Garcinia atroviridis including leaves, petioles, branches, and fruits. Results demonstrated that, most of endophytic fungal isolates showed some inhibitory action over the growth of C. gloeosporiodes during dual culture growth. Endophyte isolate F14 showed the highest antagonistic activity against Colletotrichum gloeosporiodes with 67.38% percentage inhibition radial growth (PIRG). However, 7 out of 92 isolates showed no inhibitory effect against Colletotrichum gloeosporiodes. In conclusion, endophytic fungi isolated from G. atroviridis indicate the potential as biocontrol agents. It is hoped that the finding of isolated endophytic fungi in this study with antagonistic activity against anthracnose pathogen may be used in biocontrol programmes of plant disease in the region.

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Review on Some Malaysian Traditional Medicinal Plants with Therapeutic Properties

Cited by 34 publications

References 75 publications

An exploratory analysis on the toxicity & safety profile of Polyherbal combination of curcumin, quercetin and rutin

An exploratory analysis on the toxicity & safety profile of Polyherbal combination of curcumin, quercetin and rutin

Antimicrobial, Antioxidant and Cytotoxic Activities of Cosmos Caudatus extracts

Antagonistic Activity of Fungal Endophytes Isolated from Garcinia atroviridis against Colletotrichum gloeosporioides

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